Resistance Training to Prehabilitate Patients With Chronic Obstructive Pulmonary Disease

NCT02860728 | Completed

• 1 other identifier: H16-01019
• Study Type: interventional
• Target: 25
• Locations: 1 country
• Sites: 1

Brief Summary

Structural changes in skeletal muscles of patients with chronic obstructive pulmonary disease (COPD) have been linked to impaired muscle function, reduced exercise capacity, and increased mortality associated with this disease. Muscle dysfunction also contributes to dyspnea intensity and the ability to sustain exercise, making aerobic exercise training intolerable at the intensity and/or volume required to achieve clinically important changes. Resistance training (RT) is an attractive exercise modality because it is efficacious and more tolerable initially. No work has examined whether a short-term RT program can reduce exertional symptoms and improve exercise tolerance (dyspnea and leg fatigue) in patients with COPD.

Conditions

Chronic Obstructive Pulmonary Disease

Keywords

COPD; Resistance Training; Exercise Training; Dyspnea

Outcome Measures

Primary Outcomes (1)

• Dyspnea

  The change in the sensory intensity of dyspnea measured at an iso-time during the constant load exercise trials post RT

  Baseline and post 4 weeks (12 sessions) of resistance training

Secondary Outcomes (4)

• Exercise Tolerance

  Baseline and post 4 weeks (12 sessions) of resistance training

• Secondary Dyspnea Outcomes

  Baseline and post 4 weeks (12 sessions) of resistance training

• Quadriceps Fatigue

  Baseline and post 4 weeks (12 sessions) of resistance training

• Muscle Strength and Endurance

  Baseline and post 4 weeks (12 sessions) of resistance training

Study Arms (1)

Resistance training

EXPERIMENTAL

Patients with COPD will participate in 4 weeks (12 sessions) of individualized, non-linear, lower body resistance training.

Behavioral: Individualized Resistance Training

Interventions

Individualized Resistance Training BEHAVIORAL

Lower body resistance exercises will be prescribed in various combinations over multiple days and individually modified and progressed to achieve advances in both movement pattern, intensity, and exercise volume.

Resistance training

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Non-smokers \>6 months
• FEV1/FVC \<0.7 and lower limit of normal
• %\< FEV1 pred \<70%
• Stable (no exacerbation for \>3 months)

You may not qualify if:

• Cardiovascular and cerebrovascular disease
• Diabetes
• Cardiovascular contraindications to exercise
• Uncontrolled hypertension
• Currently performing regular structured exercise \>3x/week for 30 minutes

Sponsors & Collaborators

• University of British Columbia: lead

Study Sites (1)

University of British Columbia

Kelowna, British Columbia, V1V 1V7, Canada

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Dyspnea

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms

Study Officials

• Neil Eves, PhD

  University of British Columbia

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: August 5, 2016
• First Posted: August 9, 2016
• Study Start: August 1, 2016
• Primary Completion: February 1, 2020
• Study Completion: February 1, 2020
• Last Updated: June 13, 2022

Record last verified: 2022-06

Locations

CA (1)