NCT02872987

Brief Summary

The GMALL registry serves the purpose of ALL research and quality assurance. The Registry collects data about diagnostics, treatment and outcome of Adult ALL Patients in the clinical routine, whether or not the patient is treated within a clinical trial.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
10,000

participants targeted

Target at P75+ for all trials

Timeline
117mo left

Started Feb 2009

Longer than P75 for all trials

Geographic Reach
2 countries

152 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress64%
Feb 2009Dec 2035

Study Start

First participant enrolled

February 1, 2009

Completed
7.5 years until next milestone

First Submitted

Initial submission to the registry

August 4, 2016

Completed
15 days until next milestone

First Posted

Study publicly available on registry

August 19, 2016

Completed
14.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2030

Expected
5 years until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2035

Last Updated

December 5, 2025

Status Verified

November 1, 2025

Enrollment Period

21.8 years

First QC Date

August 4, 2016

Last Update Submit

November 27, 2025

Conditions

Outcome Measures

Primary Outcomes (1)

  • Overall survival

    up to 10 years

Secondary Outcomes (13)

  • Event free survival

    up to 10 years

  • Hematologic remission rate

    after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  • Molecular remission rate

    after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  • Positron Emission Tomography (PET) based remission evaluation

    after induction and consolidation, approximately 6 - 8 weeks from diagnosis

  • Remission duration

    up to 10 years

  • +8 more secondary outcomes

Study Arms (2)

B-ALL/NHL

ALL/ Lymphoblastic Lymphoma (LBL)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Acute Lymphoblastic Leukemia or seleted NHL

You may qualify if:

  • Acute Lymphoblastic Leukemia (All Subtypes) if treated according to ALL protocols
  • Other Types of Leukemia (NK Cell Lymphoma/Leukemia, Biphenotypic Acute Leukemia) if treated according to ALL protocols
  • Non-Hodgkin's Lymphoma of Following Subtypes: Burkitt Lymphoma, B Cell Lymphoma, B- or T-lineage Lymphoblastic Lymphoma, Anaplastic Large Cell Lymphoma, Other NHL) if treated according to B-ALL protocols
  • Age minimum 18 yrs

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (152)

Universitätsklinikum Graz

Graz, Austria

RECRUITING

LKH-Hochsteiermark Leoben

Leoben, Austria

RECRUITING

Hanusch-Krankenhaus Wien

Vienna, Austria

RECRUITING

University Hospital of Frankfurt (Main)

Frankfurt am Main, Hesse, 60590, Germany

RECRUITING

Universitätsklinikum Aachen

Aachen, Germany

RECRUITING

Klinikum Altenburger Land

Altenburg, Germany

RECRUITING

Kreiskliniken Altötting

Altötting, Germany

RECRUITING

Klinikum Aschaffenburg

Aschaffenburg, Germany

RECRUITING

Klinikum Augsburg

Augsburg, Germany

RECRUITING

Helios Klinikum Bad Saarow

Bad Saarow, Germany

RECRUITING

Sozialstiftung Bamberg

Bamberg, Germany

RECRUITING

Klinikum Bayreuth

Bayreuth, Germany

RECRUITING

Alexianer St. Hedwig Krankenhaus

Berlin, Germany

RECRUITING

Charité Universitätsmedizin Berlin

Berlin, Germany

RECRUITING

Evangelisches Waldkrankenhaus Spandau

Berlin, Germany

RECRUITING

Helios Klinikum Berlin-Buch

Berlin, Germany

RECRUITING

Vivantes Klinikum Neukölln

Berlin, Germany

RECRUITING

Vivantes-Klinikum am Urban

Berlin, Germany

RECRUITING

Evangelisches Krankenhaus Bielefeld

Bielefeld, Germany

RECRUITING

Franziskus-Hospital Bielefeld

Bielefeld, Germany

RECRUITING

Klinikum Bielefeld

Bielefeld, Germany

RECRUITING

Augsuta Krankenanstalt Bochum

Bochum, Germany

RECRUITING

Katholisches Klinikum Bochum

Bochum, Germany

RECRUITING

Universitätsklinikum Knappschaftskrankenhaus Bochum

Bochum, Germany

RECRUITING

Johanniter-Krankenhaus Bonn

Bonn, Germany

RECRUITING

Universitätsklinikum Bonn

Bonn, Germany

RECRUITING

Städtisches Klinikum Braunschweig

Braunschweig, Germany

RECRUITING

Evangelische Diakonissenanstalt Bremen

Bremen, Germany

RECRUITING

Klinikum Bremen-Mitte gGmbH

Bremen, Germany

RECRUITING

Klinikum Chemnitz gGmbH

Chemnitz, Germany

RECRUITING

Universitätsklinikum Köln

Cologne, Germany

RECRUITING

Carl-Thiem-Klinikum Cottbus

Cottbus, Germany

RECRUITING

Klinikum Darmstadt

Darmstadt, Germany

RECRUITING

Städtisches Krankenhaus Dessau

Dessau, Germany

RECRUITING

Klinikum Dortmund

Dortmund, Germany

RECRUITING

St. Johannes-Hospital Dortmund

Dortmund, Germany

RECRUITING

Klinikum Carl-Gustav-Carus

Dresden, Germany

RECRUITING

Städtisches Klinikum Dresden

Dresden, Germany

RECRUITING

Helios Klinikum Duisburg

Duisburg, Germany

RECRUITING

Johanniter-Krankenhaus Duisburg

Duisburg, Germany

RECRUITING

Krankenhaus Düren

Düren, Germany

RECRUITING

Marien-Hospital Düsseldorf

Düsseldorf, Germany

RECRUITING

Universitätsklinikum Düsseldorf

Düsseldorf, Germany

RECRUITING

Helios Klinikum Erfurt

Erfurt, Germany

RECRUITING

Universitätsklinikum Erlangen

Erlangen, Germany

RECRUITING

St.-Antonius-Hospital Eschweiler

Eschweiler, Germany

RECRUITING

Evang. Krankenhaus Essen-Werden

Essen, Germany

RECRUITING

Universitätsklinikum Essen

Essen, Germany

RECRUITING

Klinikum Esslingen

Esslingen am Neckar, Germany

RECRUITING

Malteser Krankenhaus Flensburg

Flensburg, Germany

RECRUITING

Klinikum Frankfurt-Oder

Frankfurt, Germany

RECRUITING

Städt. Klinikum Frankfurt-Höchst

Frankfurt, Germany

RECRUITING

Universitätsklinikum Freiburg

Freiburg im Breisgau, Germany

RECRUITING

Klinikum Freising

Freising, Germany

RECRUITING

Klinikum Fulda

Fulda, Germany

RECRUITING

Niels-Stensen-Kliniken Georgsmarienhütte

Georgsmarienhütte, Germany

RECRUITING

Klinik der Justus-Liebig-Universität Gießen

Giessen, Germany

RECRUITING

Wilhelm-Anton-Hospital Goch

Goch, Germany

RECRUITING

Universitätsklinikum Göttingen

Göttingen, Germany

RECRUITING

Universitätsklinikum Ernst-Moritz-Arndt-Universität

Greifswald, Germany

RECRUITING

Städtisches Krankenhaus Gütersloh

Gütersloh, Germany

RECRUITING

Katholisches Krankenhaus Hagen gGmbH

Hagen, Germany

RECRUITING

Krankenhaus St. Elisabeth und St. Barbara Halle/Saale

Halle, Germany

RECRUITING

Martin-Luther-Universität Halle-Wittenberg

Halle, Germany

RECRUITING

Asklepios Klinik Altona Hamburg

Hamburg, Germany

RECRUITING

Asklepios Klinik St. Georg Hamburg

Hamburg, Germany

RECRUITING

Universitätsklinikum Hamburg-Eppendorf

Hamburg, Germany

RECRUITING

Evangelisches Krankenhaus Hamm gGmbH

Hamm, Germany

RECRUITING

St. Barbara-Klinik Hamm

Hamm, Germany

RECRUITING

Klinikum Siloah Hannover

Hanover, Germany

RECRUITING

Medizinische Hochschule Hannover

Hanover, Germany

RECRUITING

Universitätsklinikum Heidelberg

Heidelberg, Germany

RECRUITING

SLK Kliniken Heilbronn

Heilbronn, Germany

RECRUITING

Marienhospital Herne

Herne, Germany

RECRUITING

St. Bernward Krankenhaus Hildesheim

Hildesheim, Germany

RECRUITING

Universitätsklinikum des Saarlandes

Homburg/Saar, Germany

RECRUITING

Klinikum Idar-Oberstein

Idar-Oberstein, Germany

RECRUITING

Universitätsklinikum Jena

Jena, Germany

RECRUITING

St. Vincentius-Kliniken Karlsruhe

Karlsruhe, Germany

RECRUITING

Städt. Klinikum Karlsruhe

Karlsruhe, Germany

RECRUITING

Klinikum Kassel GmbH

Kassel, Germany

RECRUITING

Städtisches Krankenhaus Kiel

Kiel, Germany

RECRUITING

Universitätsklinikum Schleswig-Holstein

Kiel, Germany

RECRUITING

Gemeinschaftsklinikum Mittelrhein Koblenz

Koblenz, Germany

RECRUITING

Helios Klinikum Krefeld

Krefeld, Germany

RECRUITING

Klinikum Kulmbach

Kulmbach, Germany

RECRUITING

Klinikum Landshut

Landshut, Germany

RECRUITING

Städtisches Klinikum St. Georg Leipzig

Leipzig, Germany

RECRUITING

Universitätsklinikum Leipzig

Leipzig, Germany

RECRUITING

Klinikum Leverkusen

Leverkusen, Germany

RECRUITING

Bonifatius Hospital Lingen

Lingen, Germany

RECRUITING

Klinikum Lippe-Lemgo

Lippe, Germany

RECRUITING

Klinikum der Stadt Ludwigshafen

Ludwigshafen, Germany

RECRUITING

Sana Kliniken Lübeck

Lübeck, Germany

RECRUITING

Universitätsklinikum Schleswig-Holstein - Campus Lübeck

Lübeck, Germany

RECRUITING

Märkische Kliniken Lüdenscheid

Lüdenscheid, Germany

RECRUITING

Gemeinschaftspraxis Magdeburg

Magdeburg, Germany

RECRUITING

Universitätsklinikum Magdeburg

Magdeburg, Germany

RECRUITING

Universitätsklinikum Mainz

Mainz, Germany

RECRUITING

Klinikum Mannheim

Mannheim, Germany

RECRUITING

Universitätsklinikum Marburg

Marburg, Germany

RECRUITING

Klinikum Hochsauerland Meschede

Meschede, Germany

RECRUITING

Johannes Wesling Klinikum Minden

Minden, Germany

RECRUITING

Kliniken Maria Hilf Mönchengladbach

Mönchengladbach, Germany

RECRUITING

Stauferklinikum Mutlangen

Mutlangen, Germany

RECRUITING

Klinikum München-Bogenhausen

München, Germany

RECRUITING

Klinikum Rechts der Isar der TU München

München, Germany

RECRUITING

Rotkreuzklinikum München

München, Germany

RECRUITING

Städtisches Krankenhaus München-Neuperlach

München, Germany

RECRUITING

Universitätsklinikum München-Großhadern

München, Germany

RECRUITING

Universitätsklinikum Münster

Münster, Germany

RECRUITING

Dietrich-Bonhoeffer-Klinikum Neubrandenburg

Neubrandenburg, Germany

RECRUITING

Klinikum Nürnberg Nord

Nuremberg, Germany

RECRUITING

Ortenau Klinikum Offenburg

Offenburg, Germany

RECRUITING

Klinikum Oldenburg

Oldenburg, Germany

RECRUITING

Pius-Hospital Oldenburg

Oldenburg, Germany

RECRUITING

Klinikum Osnabrück

Osnabrück, Germany

RECRUITING

Brüderkrankenhaus St. Josef Paderborn

Paderborn, Germany

RECRUITING

Klinikum Passau

Passau, Germany

RECRUITING

Klinikum Ernst von Bergmann

Potsdam, Germany

RECRUITING

Kliniken Vest Recklinghausen

Recklinghausen, Germany

RECRUITING

Krankenhaus Barmherzige Brüder Regensburg

Regensburg, Germany

RECRUITING

Universitätsklinikum Regensburg

Regensburg, Germany

RECRUITING

Kreiskliniken Reutlingen

Reutlingen, Germany

RECRUITING

Elblandklinikum Riesa

Riesa, Germany

RECRUITING

Klinikum Südstadt Rostock

Rostock, Germany

RECRUITING

Universitätsklinikum Rostock

Rostock, Germany

RECRUITING

Diakoniekrankenhaus Rotenburg

Rotenburg (Wümme), Germany

RECRUITING

Marienhaus Klinikum Saarlouis

Saarlouis, Germany

RECRUITING

Nordwest-Krankenhaus Sanderbusch

Sande, Germany

RECRUITING

Diakonie-Krankenhaus

Schwäbisch Hall, Germany

RECRUITING

Helios Klinikum Schwerin

Schwerin, Germany

RECRUITING

Ev. Jung-Stilling Krankenhaus Siegen

Siegen, Germany

RECRUITING

St. Marienkrankenhaus Siegen

Siegen, Germany

RECRUITING

Klinikum Südwest Sindelfingen

Sindelfingen, Germany

RECRUITING

Diakonie-Klinikum Stuttgart

Stuttgart, Germany

RECRUITING

Klinikum Stuttgart Katharinenhospital

Stuttgart, Germany

RECRUITING

Marienhospital Stuttgart

Stuttgart, Germany

RECRUITING

Robert-Bosch-Krankenhaus

Stuttgart, Germany

RECRUITING

Klinikum Traunstein

Traunstein, Germany

RECRUITING

Krankenhaus der Barmherzigen Brüder

Trier, Germany

RECRUITING

Mutterhaus der Borromäerinnen Trier

Trier, Germany

RECRUITING

Universitätsklinikum Tübingen

Tübingen, Germany

RECRUITING

Bundeswehrkrankenhaus Ulm

Ulm, Germany

RECRUITING

Medizinische Universitätsklinikum Ulm

Ulm, Germany

RECRUITING

Klinikum Schwarzwald-Baar Villingen

Villingen-Schwenningen, Germany

RECRUITING

Helios Dr. Horst Schmidt Kliniken Wiesbaden

Wiesbaden, Germany

RECRUITING

Rems-Murr-Kliniken Winnenden

Winnenden, Germany

RECRUITING

Klinikum der Stadt Wolfsburg

Wolfsburg, Germany

RECRUITING

Helios Klinikum Wuppertal

Wuppertal, Germany

RECRUITING

Universitätsklinikum Würzburg

Würzburg, Germany

RECRUITING

Heinrich-Braun-Klinikum Zwickau

Zwickau, Germany

RECRUITING

Biospecimen

Collection of biomaterial (bone marrow and peripheral blood) The biomaterial samples are stored pseudonymized in the laboratory of the medical clinic II of the university hospital Frankfurt am Main. The collection intends to give physicians and scientists the possibility to have access to biomaterial for ALL related research projects. For consignment of samples for research projects a request for use has to be placed to the GMALL Biobank. The scientific panel of the GMALL Biobank decides about the assignment of the samples.

MeSH Terms

Conditions

Precursor Cell Lymphoblastic Leukemia-LymphomaLeukemiaLymphoma, Non-Hodgkin

Condition Hierarchy (Ancestors)

Leukemia, LymphoidNeoplasms by Histologic TypeNeoplasmsHematologic DiseasesHemic and Lymphatic DiseasesLymphoproliferative DisordersLymphatic DiseasesImmunoproliferative DisordersImmune System DiseasesLymphoma

Study Officials

  • Nicola Gökbuget, Dr. med.

    University Hospital of Frankfurt (Main)

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Nicola Gökbuget, Dr. med.

CONTACT

GMALL Study center

CONTACT

Study Design

Study Type
observational
Observational Model
OTHER
Time Perspective
PROSPECTIVE
Target Duration
15 Years
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Head of GMALL

Study Record Dates

First Submitted

August 4, 2016

First Posted

August 19, 2016

Study Start

February 1, 2009

Primary Completion (Estimated)

December 1, 2030

Study Completion (Estimated)

December 1, 2035

Last Updated

December 5, 2025

Record last verified: 2025-11

Data Sharing

IPD Sharing
Will not share

Locations