The Influence of Different Dietary Status on the Acute Responses to Exercise
1 other identifier
interventional
10
0 countries
N/A
Brief Summary
The purpose of this study is to investigate whether dietary conditions (fed versus fasted) affects the acute responses to exercise.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2013
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2013
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2014
CompletedStudy Completion
Last participant's last visit for all outcomes
January 1, 2016
CompletedFirst Submitted
Initial submission to the registry
February 9, 2016
CompletedFirst Posted
Study publicly available on registry
August 17, 2016
CompletedAugust 17, 2016
August 1, 2016
1.4 years
February 9, 2016
August 11, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Changes in gene expression in the adipose tissue
Before the meal and 1 h after exercise (255 minutes)
Secondary Outcomes (3)
Changes in insulin, glucose, TAG and NEFA in blood
255 minutes
Changes in serum Interleukin-6 (IL-6), leptin and adiponectin
255 minutes
Changes in Interleukin-6 (IL-6), leptin and adiponectin protein secretion from adipose tissue explants
Before the meal and 1 h after exercise (255 minutes)
Study Arms (2)
Fed exercise
ACTIVE COMPARATORFed prior to exercise
Fasted exercise
ACTIVE COMPARATORFasted prior to exercise
Interventions
Participants consumed a meal (Fed) 2 h prior to 1 h moderate intensity exercise at 60% VO2max.
Participants remained fasting (Fasted) 2 h prior to 1 h moderate intensity exercise at 60% VO2max.
Eligibility Criteria
You may qualify if:
- Male
- Aged between 18 to 35 years
- Central overweight (waist circumference 94-128 cm)
- Weight stable for more than 3 months (no change in weight +/- 3%)
- Non-smoker
- Able to walk for a long period of time
You may not qualify if:
- Personal history of/existing diabetes, cardiovascular disease, metabolic disease or dyslipidaemia
- Waist circumference \< 94cm and \>128cm
- Taking medications that may influence lipid or carbohydrate metabolism or immune system function
- Unable to take part in structured exercise for any reason (e.g., injury or disability) or a positive response to any questions on the Physical Activity Readiness questionnaire (PAR-Q)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Bathlead
- Ministry of Education, Taiwancollaborator
Related Publications (1)
Chen YC, Travers RL, Walhin JP, Gonzalez JT, Koumanov F, Betts JA, Thompson D. Feeding influences adipose tissue responses to exercise in overweight men. Am J Physiol Endocrinol Metab. 2017 Jul 1;313(1):E84-E93. doi: 10.1152/ajpendo.00006.2017. Epub 2017 Mar 14.
PMID: 28292758DERIVED
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- PhD student
Study Record Dates
First Submitted
February 9, 2016
First Posted
August 17, 2016
Study Start
May 1, 2013
Primary Completion
October 1, 2014
Study Completion
January 1, 2016
Last Updated
August 17, 2016
Record last verified: 2016-08