Cognitive Inhibition, Psychosocial Interactions and Suicide Attempt in Elderly

NCT02858427 | Unknown

• 1 other identifier: P/2016/288
• Study Type: interventional
• Target: 36
• Locations: 1 country
• Sites: 2

Brief Summary

The study aims to determine the correlation between the cognitive inhibition impairment and the history of suicide attempt in elderly depressed patients.

Conditions

Suicide

Keywords

cognitive inhibition; elderly; suicide attempt; depression

Outcome Measures

Primary Outcomes (1)

• antisaccade error rate

  1 month max. after inclusion

Secondary Outcomes (6)

• saccade accuracy

  1 month max. after inclusion

• saccadic intrusion

  1 month max. after inclusion

• maximal speed of the gaze

  1 month max. after inclusion

• saccade reaction time

  1 month max. after inclusion

• fixation duration on pictures

  1 month max. after inclusion

Other Outcomes (1)

• neuropsychological test score

  1 month max. after inclusion

Study Arms (2)

depressed with suicide attempt (SA)

EXPERIMENTAL

elderly depressed patients with a history of suicide attempt. interventions: eye tracking, neuropsychological assessment, psychiatric assessment and sociological interview.

Behavioral: eye tracking; Behavioral: neuropsychological assessement; Behavioral: psychiatric assessment; Behavioral: sociological interview

depressed without a history of SA

EXPERIMENTAL

elderly depressed patients without a history of suicide attempt. interventions: eye tracking, neuropsychological assessment, psychiatric assessment and sociological interview.

Behavioral: eye tracking; Behavioral: neuropsychological assessement; Behavioral: psychiatric assessment; Behavioral: sociological interview

Interventions

eye tracking BEHAVIORAL

several oculomotor parameters will be recorded using vide-oculography techniques (eye tracking) trough different tasks: saccade, antisaccade, and picture scanning. Saccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the red dot appearing on the periphery of the screen. Prosaccade task: the patient is looking at a screen and is asked to fix his gaze as quickly and accurately as possible on the opposite side relative to the red dot appearing on the periphery of the screen. Picture Scanning: participant is instructed to freely watch pictures with different emotional valence.

depressed with suicide attempt (SA); depressed without a history of SA

neuropsychological assessement BEHAVIORAL

the neuropsychological assessment aims to identify any impairment of executive functioning through several tasks: Mini mental state examination (mmse), isaac set test (STI) trail making test (TMT A and B), Grober test, Stroop test, verbal fluency, Go No Go task, memory impairment screen (MIS), picture naming test (DO30), copying figure test, digit span and categorical matching test.

depressed with suicide attempt (SA); depressed without a history of SA

psychiatric assessment BEHAVIORAL

this evaluation aims to characterize the mental status of the patient. Different scales will be used: Montgomery and ASberg depression rating scale (MADRS), Columbia-suicide severity rating scale (C-SSRS), Beck depression inventory (BDI), Barratt impulsiveness scale (BIS-10), Buss and Durkee Hostility Inventory (BDHI), Balloon, analogue risk task (BART), Iowa gambling task (IGT), and Childhood trauma questionnaire (CTQ).

depressed with suicide attempt (SA); depressed without a history of SA

sociological interview BEHAVIORAL

this interview aims to characterize social interactions of the patients, their duration, their evolution and the perception of each participant on this subject.

depressed with suicide attempt (SA); depressed without a history of SA

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• major depressive disorder according to Diagnostic ans Statistical Manual (DSM) V
• group 1: with a history of suicide attempt
• group 2: without a history of suicide attempt

You may not qualify if:

• other psychiatric disease
• guardianship

Sponsors & Collaborators

• Centre Hospitalier Universitaire de Besancon: lead

Study Sites (2)

CHU Besancon

Besançon, Doubs, 25030, France

RECRUITING

CHS Bavilliers

Bavilliers, France

NOT YET RECRUITING

MeSH Terms

Conditions

Suicide; Suicide, Attempted; Depression

Condition Hierarchy (Ancestors)

Self-Injurious Behavior; Behavioral Symptoms; Behavior

Study Officials

• pierre vandel, MD PhD

  Centre Hospitalier Universitaire de Besancon

  PRINCIPAL INVESTIGATOR

Central Study Contacts

julie monnin, PhD

CONTACT

0033381218543; jmonnin@chu-besancon.fr

kristina mouyabi

CONTACT

0033381218356; kmouyabi@chu-besancon.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: August 1, 2016
• First Posted: August 8, 2016
• Study Start: February 6, 2017
• Primary Completion: August 6, 2019
• Study Completion: February 6, 2020
• Last Updated: October 13, 2017

Record last verified: 2017-10

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)