Emotional Prosody Recognition and Decision Making Inf fMRI and Vulnerability to Suicide

NCT02901769 | Unknown

• 1 other identifier: 2011-A00944-37
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Suicide is known to be frequent in depression, and in most of the psychiatric diseases. But as it can occur in patients with no psychiatric illness and doesn't occur in every patients with psychiatric illness, it has to be considered henceforth as a specific vulnerability. This trial will study two fMRI paradigms, emotional prosody recognition and decision making, in order to characterize emotional and cognitive trait factors in a population of patients vulnerable to suicide. Four different groups will be constituted : depressed suicide attempters, depressed patients with past history of suicidal acts, depressed patients with no history of suicidal acts and healthy controls. The main goal will be to correlate fMRI activation during the two paradigms in subjects vulnerable to suicide. The secondary goals will be to characterize emotional and cognitive trait factors in these subjects, to demonstrate that those characteristics are independent from depression and to correlate these trait factors with socio-demographic and clinical features with fMRI activations.

Conditions

Suicide

Outcome Measures

Primary Outcomes (1)

• fMRI activation area

  1 day

Study Arms (4)

Depressed suicide attempters

EXPERIMENTAL

20 subjects

Other: fMRI

Depressed patients with past history of

EXPERIMENTAL

20 subjects

Other: fMRI

Depressed patients with no history of

EXPERIMENTAL

20 subjects

Other: fMRI

Healthy controls

PLACEBO COMPARATOR

20 subjects

Other: fMRI

Interventions

fMRI OTHER

two fMRI paradigms, emotional prosody recognition and decision making

Depressed patients with no history of; Depressed patients with past history of; Depressed suicide attempters; Healthy controls

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Right-handed,
• Depressed suicide attempters for the first group,
• Depressed patients with past history of suicidal acts for the second group,
• Depressed patients with no history of suicidal acts for the third group,
• Healthy controls for the fourth group.

You may not qualify if:

• Another psychiatric trouble than depression,
• For the first and secand groups : more than fous suicidals acts within the past 3 years,
• Deficits that do not allow test realisation (visual audition troubles, cognitif deficits,
• Prosopagnosia,
• Pregnancy,
• Severe central nervous system disease or somatic disease,
• MRI contra-indication,
• Major benefiting from a legal protective measure,
• No coverage care.

Sponsors & Collaborators

• Rennes University Hospital: lead

Study Sites (1)

Rennes university hospital

Rennes, 35000, France

RECRUITING

MeSH Terms

Conditions

Suicide

Condition Hierarchy (Ancestors)

Self-Injurious Behavior; Behavioral Symptoms; Behavior

Central Study Contacts

David Travers, MD

CONTACT

02 99 28 67 67; david.travers@chu-rennes1.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: September 5, 2016
• First Posted: September 15, 2016
• Study Start: February 1, 2013
• Primary Completion: February 1, 2019
• Study Completion: February 1, 2020
• Last Updated: September 15, 2016

Record last verified: 2016-09

Locations

FR (1)