Predictive Factors of Systolic Dysfunction in Non-complicated Hypertensive Patients

NCT02841696 | Completed

• 1 other identifier: CHUBX 2014/07
• Study Type: observational
• Target: 183
• Locations: 1 country
• Sites: 1

Brief Summary

Hypertension is a major cardiovascular risk factor. Heart failure is one of its main complications but the factors that influence its development are still insufficiently known. The primary objective is to determine associated factors to the occurrence of left ventricular (LV) systolic dysfunction assessed by an alteration of the Global Longitudinal Strain (GLS) after more than the years of hypertension. The secondary objective is to estimate the prevalence of LV systolic dysfunction in a cohort of hypertensive people followed for over 10 years and formulate pathophysiological hypotheses on the development of this heart disease.

Conditions

Hypertension

Keywords

Heart failure; Systolic dysfunction; GLS; Arterial stiffness; Left ventricular hypertrophy

Outcome Measures

Primary Outcomes (1)

• Measure of GLS

  GLS measurement is a percentage obtained on cuts apical 4-chamber, 2-aortic cavities and 2 cavities (average of 3 impacts) after locating the aortic pulsed Doppler of the opening and closing of the aortic valve. GLS \< -17% for men and \< -19% for women.

  Day 1

Study Arms (1)

Hypertensive people

Hypertensive people recruited 10 years ago before any anti-hypertensive treatment

Device: Cardiac echography

Interventions

Cardiac echography DEVICE

The exam is in the left lateral decubitus position. 4 electrodes are applied to the patient's chest for a synchronization with the Electrocardiogram (ECG). The examination is conducted as standard with acquisition loops of records in parasternal long axis parasternal short axis, apical 4-cavities, 2-cavities and aorta 2 cavities.

Hypertensive people

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subject with a confirmed hypertension before any anti-hypertensive treatment more than 10 years ago. Patients are selected according their date of inclusion in the cohort. The investigators will start to contact the most recently recruited patients.

You may qualify if:

• Patient who was diagnosed as hypertensive more than 10 years ago and who underwent cardiac-echography, ECG, a biological blood test and an ambulatory blood pressure measurement before the introduction of antihypertensive treatment.

You may not qualify if:

• Oral refusal of patient participation or its legal representatives, reading the specific information note for the study.

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

University Hospital Bordeaux

Bordeaux, 33000, France

Location

MeSH Terms

Conditions

Hypertension; Heart Failure; Hypertrophy, Left Ventricular

Condition Hierarchy (Ancestors)

Vascular Diseases; Cardiovascular Diseases; Heart Diseases; Cardiomegaly; Hypertrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Study Officials

• Paul PEREZ, MD

  University Hospital, Bordeaux

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 20, 2016
• First Posted: July 22, 2016
• Study Start: September 14, 2016
• Primary Completion: May 15, 2019
• Study Completion: May 15, 2019
• Last Updated: February 9, 2022

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)