Validation of Laser Doppler Vibrometer (LDV) for Measurement of Arterial Stiffness in Hypertensive Patients
CARDIS-PWV
1 other identifier
interventional
100
1 country
1
Brief Summary
The aim is to compare a new technique for assessing local and regional arterial stiffness: the Laser Doppler Vibrometry with the reference techniques, the applanation tonometry and echotracking.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable hypertension
Started Jun 2018
Shorter than P25 for not_applicable hypertension
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 19, 2018
CompletedFirst Posted
Study publicly available on registry
February 26, 2018
CompletedStudy Start
First participant enrolled
June 21, 2018
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 4, 2018
CompletedStudy Completion
Last participant's last visit for all outcomes
December 4, 2018
CompletedSeptember 3, 2025
September 1, 2019
6 months
February 19, 2018
September 1, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
carotid-femoral PWV measured by LDV
day 1
Secondary Outcomes (4)
carotid PWV measured by LDV
day 1
chest-carotid PWV measured by LDV
day 1
carotid-femoral PWV measured by applanation tonometry
day 1
carotid PWV measured by Echotracking
day 1
Study Arms (1)
Hypertensives
EXPERIMENTALPWV measurement by LDV
Interventions
PWV measurement by LDV : carotid-femoral, carotid and chest-carotid
Eligibility Criteria
You may qualify if:
- Patients with grade I-III essential arterial hypertension, recently diagnosed, well controlled or insufficiently equilibrated under stable antihypertensive treatment for their HTA
You may not qualify if:
- Severe pathologies interfering with HTA or not allowing measurement by the techniques of interest, including skin diseases impeding the applanation tonometry
- Allergies to ultrasound gel or to adhesive film
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hopital Européen Georges Pompidou / Service de Pharmacologie
Paris, 75015, France
Related Publications (2)
Parker MA. Case of localized recombination in 23S rRNA genes from divergent bradyrhizobium lineages associated with neotropical legumes. Appl Environ Microbiol. 2001 May;67(5):2076-82. doi: 10.1128/AEM.67.5.2076-2082.2001.
PMID: 11319084BACKGROUNDBadhwar S, Marais L, Khettab H, Poli F, Li Y, Segers P, Aasmul S, de Melis M, Baets R, Greenwald S, Bruno RM, Boutouyrie P. Clinical Validation of Carotid-Femoral Pulse Wave Velocity Measurement Using a Multi-Beam Laser Vibrometer: The CARDIS Study. Hypertension. 2024 Sep;81(9):1986-1995. doi: 10.1161/HYPERTENSIONAHA.124.22729. Epub 2024 Jun 27.
PMID: 38934112DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Pierre Boutouyrie, MD, PhD
Pharmacology Department - Hopital Européen Georges Pompidou - Paris
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- OTHER
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER GOV
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 19, 2018
First Posted
February 26, 2018
Study Start
June 21, 2018
Primary Completion
December 4, 2018
Study Completion
December 4, 2018
Last Updated
September 3, 2025
Record last verified: 2019-09
Data Sharing
- IPD Sharing
- Will not share