Characterization of Emotional Processing of Information in Bipolar Disorder and Schizophrenic Patients

NCT02841345 | Unknown DMC

• 1 other identifier: 38RC11.210
• Study Type: interventional
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

In the case of psychotic disorders such as bipolar disorder or schizophrenia, attention dysfunction contribute, according to the theories of neuroscience, the development of mood disorders following disturbances in the interaction-care emotion. In this context, the general objective of this research project is to refine our understanding of the similarities and distinctions between bipolar and schizophrenic patients in the basic emotional information processing. Specifically, these are: 1) to better understand what level of basic emotional information processing both conditions differ or are comparable and in what sense and 2) estimate, in both pathologies, the specific influence of the nature of the task of processing emotional information. To answer these questions, the investigators have developed a protocol to specifically target different information processing channels playing on the nature of the spatial frequency content of emotional natural scenes. To estimate in both pathologies, the specific influence of the nature of the task on emotional processing, 3 types of tasks are proposed: 1) a simple task perception and 2) -3) two tasks whose categorization one focused on the emotional feelings of the individual and the other on the tendency to action. Both tasks categorization should involve more specifically the ventromedial prefrontal cortex (CPFVM) and the dorsolateral prefrontal cortex (DLPFC) respectively. All patient data will be compared with data from healthy control participants.

Conditions

Schizophrenia; Bipolar Disorder

Keywords

emotional processing; action

Outcome Measures

Primary Outcomes (5)

• Psychometric evaluation

  PANSS - POSITIVE AND NEGATIVE SYNDROME SCALE Scale with 30 items

  70 minutes

• Psychometric evaluation

  MADRS - Montgomery Asberg Depression Rating

  15 minutes

• Psychometric evaluation

  YMRS - Young Mania Rating Scale

  15 minutes

• Self-Questionnaire

  SHAPS - Snaith-Hamilton Pleasure Scale Starkstein STAI Y - State-Trait Anxiety Inventory AIM: "affect intensity measure" ALS: "affective lability scale" MATHYS

  Few hours

• Cognitive questionnaire

  CPT II - Conners' Continuous Performance Test II

  15 minutes

Study Arms (3)

Bipolar

OTHER

bipolar patients type I or II (DSM-IV TR), euthymic phase

Other: behavioral and fMRI

Schizophrenic

OTHER

schizophrenic loss or paranoid or undifferentiated patients

Other: behavioral and fMRI

Control

OTHER

control group (paired in age and sex for patients)

Other: behavioral and fMRI

Interventions

behavioral and fMRI OTHER

The experience will include 3 sessions. Each session will consist of the presentation of a pseudo-random sequence of 24 black and white images of negative emotional natural scenes, 24 positive emotional situations and 24 neutral emotional situations. * In the first session, participants will carry out an emotional assessment task: it will show at the end of each test his emotional feeling - pleasant, unpleasant or nothing - using a joystick. * In a second session, the participant will perform a motor task decision: it will show at the end of each test the tendency to action he would handle the situation actually using 3 buttons également- approach withdrawal or neither one nor the other. * In the third session, the participant will perform a simple visual perception task. To be comparable to the engine plane with the other sessions, a non-categorical motor task will be requested from participants.

Bipolar; Control; Schizophrenic

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Informed Consent signed
• Medical examination conducted before research participation
• Age, sex and level of education paired with bipolar and schizophrenic patients)
• French Language and Culture
• normal or corrected vision and hearing to normal
• affiliate Obligation to social security

You may not qualify if:

• Topic included in an ongoing experiment
• contraindication to MRI (metal hardware or electronic incompatible with MRI examination, permanent glasses, braces, Claustrophobia, cardiac or neurological stimulator, Clip unsecured vascular nonmagnetic metal Eclat)
• Important Hearing Disorders and vision
• neurological pathologies or past or current neuropsychiatric
• Family history of psychiatric disorders
• Drug treatment may modulate brain activity: benzodiazepines, antidepressants, neuroleptics, etc.
• Alcohol Ingestion
• Pregnant women, women in labor, nursing mother
• All other categories of protected persons
• bipolar patients
• Informed Consent signed
• Membership or beneficiary of a social security scheme
• Age over 18 years
• Language and French culture
• study BAC level or equivalent

Sponsors & Collaborators

• University Hospital, Grenoble: lead

Study Sites (1)

GrenobleUniversityHospital

La Tronche, 38700, France

RECRUITING

MeSH Terms

Conditions

Schizophrenia; Bipolar Disorder

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders; Bipolar and Related Disorders; Mood Disorders

Study Officials

• AURELIE CAMPAGNE, PhD

  LPNC

  STUDY DIRECTOR

• MIRCEA POLOSAN, PhD MD Pr.

  GrenobleUniversityHospital

  PRINCIPAL INVESTIGATOR

Central Study Contacts

VANESSA ESPIN

CONTACT

4 76 76 68 13; VEspin@chu-grenoble.fr

EMILIE COUSIN, PhD

CONTACT

0 13 63 86 45; cousin.emilie@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 16, 2016
• First Posted: July 22, 2016
• Study Start: December 1, 2011
• Primary Completion: February 29, 2020
• Study Completion: February 29, 2020
• Last Updated: October 11, 2018

Record last verified: 2018-10

Locations

FR (1)