Emotions in Schizophrenia and Bipolar Disorders: a Common Vulnerability?

NCT02805088 | Unknown

• 1 other identifier: PO13116
• Study Type: interventional
• Target: 240
• Locations: 1 country
• Sites: 1

Brief Summary

The initial aim of the project was to gain an understanding of the comprehension of "language-oriented" emotions among schizophrenic and bipolar patients. By "language-oriented" emotions, the investigators mean the emotions that are conveyed by means of language, whether through the emotional valence of the words, the expression of an emotional state or emotional prosody. Although they involve different diagnostic categories, schizophrenic and bipolar disorders nevertheless share a number of symptoms, in particular in the emotional sphere, and do so to such an extent that the question of whether there may, at the clinical, cognitive and etiopathogenic levels, exist a continuum between these disorders is frequently raised. Taking this hypothesis of a clinical continuum as our starting point, the investigators explored the understanding of emotions contextualized by language in these two clinical populations, namely patients exhibiting schizophrenic and bipolar disorders. To these populations, the investigators also added the dimension of vulnerability in the form of non-clinical participants varying in terms of their traits of schizotypy and hypomania, thus orienting this project toward the early identification of cognitive-emotional markers and possibly also their prevention.

Conditions

Bipolar Disorder; Schizophrenia

Outcome Measures

Primary Outcomes (1)

• Event-related brain potentials (ERP)

  within 30 days

Study Arms (3)

Bipolar Disorder patients

EXPERIMENTAL

Other: Electroencephalographic recordings; Other: neuropsychological evaluation; Other: clinical evaluation of symptoms

Schizophrenia patients

EXPERIMENTAL

Other: Electroencephalographic recordings; Other: neuropsychological evaluation; Other: clinical evaluation of symptoms

Healthy Volunteers

EXPERIMENTAL

Other: Electroencephalographic recordings; Other: neuropsychological evaluation; Other: clinical evaluation of symptoms

Interventions

Electroencephalographic recordings OTHER

Bipolar Disorder patients; Healthy Volunteers; Schizophrenia patients

neuropsychological evaluation OTHER

Bipolar Disorder patients; Healthy Volunteers; Schizophrenia patients

clinical evaluation of symptoms OTHER

Bipolar Disorder patients; Healthy Volunteers; Schizophrenia patients

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients :
• Men or women, right-handed, with a diagnosis of bipolar disorder or schizophrenia, according to the DSM-IV criteria, aged from 18 to 65 years-old Native French speaker Clinically stabilised Able to provide informed written and verbal consent
• Healthy Controls :
• Men or women, right-handed, aged from 18 to 65 years-old Native French speaker Able to provide informed written and verbal consent

You may not qualify if:

• Patients :
• A recent alcohol and/or drug abuse or dependence A significant general medical illness, including neurological disorders or head trauma A sensorial impairment (visual and/or hearing)
• Healthy Controls :
• A personal or first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV A recent alcohol and/or drug abuse or dependence A significant general medical illness, including neurological disorders or head trauma A sensorial impairment (visual and/or hearing)

Sponsors & Collaborators

• CHU de Reims: lead

Study Sites (1)

Chu Reims

France, Reims, 51092, France

RECRUITING

Related Publications (3)

• Terrien S, Gobin P, Iakimova G, Coutte A, Thuaire F, Baltazart V, Mazzola-Pomietto P, Besche-Richard C. Electrophysiological correlates of emotional meaning in context in relation to facets of schizotypal personality traits: A dimensional study. Psychiatry Clin Neurosci. 2016 Mar;70(3):141-50. doi: 10.1111/pcn.12366. Epub 2015 Dec 22.

  PMID: 26482112 RESULT

• Terrien S, Gobin P, Coutte A, Thuaire F, Iakimova G, Mazzola-Pomietto P, Besche-Richard C. Emotional Meaning in Context in Relation to Hypomanic Personality Traits: An ERP Study. PLoS One. 2015 Sep 22;10(9):e0138877. doi: 10.1371/journal.pone.0138877. eCollection 2015.

  PMID: 26394230 RESULT

• Terrien S, Stefaniak N, Morvan Y, Besche-Richard C. Factor structure of the French version of the Hypomanic Personality Scale (HPS) in non-clinical young adults. Compr Psychiatry. 2015 Oct;62:105-13. doi: 10.1016/j.comppsych.2015.07.001. Epub 2015 Jul 8.

  PMID: 26343474 RESULT

MeSH Terms

Conditions

Bipolar Disorder; Schizophrenia

Condition Hierarchy (Ancestors)

Bipolar and Related Disorders; Mood Disorders; Mental Disorders; Schizophrenia Spectrum and Other Psychotic Disorders

Central Study Contacts

Arthur KALADJIAN

CONTACT

326787045; akaladjian@chu-reims.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 15, 2016
• First Posted: June 17, 2016
• Study Start: February 1, 2014
• Primary Completion: August 1, 2016
• Last Updated: June 21, 2016

Record last verified: 2016-06

Locations

FR (1)