Dynamic Hyperinflation During Maximal Voluntary Ventilation in Healthy Subjects

NCT02831465 | Unknown

• 1 other identifier: B076201318918
• Study Type: interventional
• Target: 45
• Locations: 1 country
• Sites: 1

Brief Summary

Maximal Voluntary Ventilation (MVV) correlates well with maximal exercise capacity and is used to assess the ventilatory function during exercise in COPD (Chronic Obstructive Pulmonary Disease) patients. Dynamic hyperinflation (DH) often occurs during MVV in COPD and is believed to be due to expiratory flow limitation. The present study is intended to assess whether DH can also occur during MVV in normal subjects without expiratory flow limitation.

Conditions

Dynamic Hyperinflation

Keywords

Dynamic hyperinflation; Maximal Voluntary Ventilation; Inspiratory capacity; healthy subjects

Outcome Measures

Primary Outcomes (1)

• Frequency which induces Dynamic Hyperinflation

  We analyze Frequency of Maximal Voluntary Ventilation (MVV) which induces a significant decrease of the Inspiratory Capacity (IC) post MVV compared to the IC at rest.

  day one

Secondary Outcomes (8)

• Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Expiratory Volume in one second

  day one

• Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Vital Capacity

  day one

• Correlation between the frequency which induces Dynamic Hyperinflation (DH) and Forced Expiratory Flows at 25%, 50% and 75% of Forced Vital Capacity

  day one

• Correlation between the frequency which induces Dynamic Hyperinflation (DH) and age

  day one

• Correlation between the frequency which induces Dynamic Hyperinflation (DH) and body mass index

  day one

Study Arms (1)

healthy subjects

EXPERIMENTAL

Subjects with normal lung function between 40 and 70 years old.

Behavioral: Healthy Subjects

Interventions

Healthy Subjects BEHAVIORAL

Subjects with normal lung function performed MVV at increasing breathing frequencies and maximal tidal volume, from 10 to 100 cycles per minute. Inspiratory capacity (IC) was measured at rest and after each 12 seconds of MVV in order to detect DH. From the moment DH appeared at a given frequency, only one additional MVV at a higher breathing frequency was conducted to confirm DH.

healthy subjects

Eligibility Criteria

• Age: 40 Years - 69 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy subjects

You may not qualify if:

• History of asthma, obstructive syndrome on basic lung function

Sponsors & Collaborators

• Centre Hospitalier Universitaire Saint Pierre: lead

Study Sites (1)

CHU St. Pierre

Brussels, Brussels Capital, 1000, Belgium

RECRUITING

Study Officials

• Vincent Ninane, MD, PhD

  University Hospital Center Saint Pierre chest service

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Audrey Herpeux

CONTACT

003225067323; audrey_herpeux@stpierre-bru.be

Inge Muylle, MD

CONTACT

003225354295; inge_muylle@stpierre-bru.be

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 11, 2016
• First Posted: July 13, 2016
• Study Start: April 1, 2015
• Primary Completion: May 1, 2017
• Study Completion: June 1, 2017
• Last Updated: February 2, 2017

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will not share

Locations

BE (1)