Third Ventricle Echographic Study for Neuro-intensive Care Unit Patients

NCT02830269 | Completed DMC

• 2 other identifiers: 97202016-A00749-42
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Transcranial Doppler ultrasonography is usually used in the evaluation and management of patients with brain injury. This noninvasive method measures local blood flow velocity and direction in the proximal portions of large intracranial arteries. The operator requires a short training and experience to perform. The third ventricle diameter measurement by transcranial duplex flow sonography was performed in healthy volunteers . This studies show similar results in those obtained with the MRI or Computer Tomography (CT). Currently the third ventricle diameter measurements by transcranial Doppler ultrasonography was not validated for neuro-intensive care unit patients. The investigators propose to used recent ultrasound system to validate the third ventricle diameter measurements in comparison with the standard method (CT).

Conditions

Neuro-intensive Care Unit Patients; Brain Injuries

Keywords

Neuro-ICU; Third ventricle; Computer Tomography; Transcranial Doppler ultrasonography

Outcome Measures

Primary Outcomes (1)

• Third ventricle diameter (average +/- standard deviation)

  Spearman's test measuring the correlation coefficient between the third ventricle diameter measured by the expert using the ultrasonography and the third ventricle diameter measured by CT scan.

  Through study completion (30 months)

Secondary Outcomes (1)

• Residents' learning curve

  24 months

Interventions

Transcranial Doppler ultrasonography measurements DEVICE

Third ventricle diameter measurements with standard method (CT) and Transcranial Doppler ultrasonography

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

All patients admitted to the neurointensive care

You may qualify if:

• Adult, \> or equal to 18-yr
• Admission to neuro-intensive care unit with brain injury
• Evaluation by Computer Tomography
• Indication for Transcranial Doppler ultrasonography

You may not qualify if:

• Opposition to participate by the patient or a next of kin

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

UHMontpellier

Montpellier, 34295, France

Location

Related Publications (1)

• Widehem R, Bory P, Greco F, Pavillard F, Chalard K, Mas A, Djanikian F, Carr J, Molinari N, Jaber S, Perrigault PF, Chanques G. Transcranial sonographic assessment of the third ventricle in neuro-ICU patients to detect hydrocephalus: a diagnostic reliability pilot study. Ann Intensive Care. 2021 May 4;11(1):69. doi: 10.1186/s13613-021-00857-x.

  PMID: 33945045 DERIVED

MeSH Terms

Conditions

Brain Injuries

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Study Officials

• GERALD CHANQUES, MD, Ph D

  University Hospital, Montpellier

  STUDY DIRECTOR

• Pierre-François PERRIGAULT, MD

  University Hospital, Montpellier

  STUDY CHAIR

• Paul BORY, MD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 10, 2016
• First Posted: July 12, 2016
• Study Start: August 18, 2016
• Primary Completion: May 16, 2017
• Study Completion: May 16, 2017
• Last Updated: December 5, 2018

Record last verified: 2017-04

Locations

FR (1)