NCT02804659

Brief Summary

Molecular analysis of the atheroma plaque. Screening for a novel biomarker of carotid status.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
14

participants targeted

Target at below P25 for all trials

Timeline
Completed

Started Mar 2015

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 26, 2015

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

June 15, 2016

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 17, 2016

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 26, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 26, 2018

Completed
Last Updated

June 12, 2026

Status Verified

June 1, 2026

Enrollment Period

2.9 years

First QC Date

June 15, 2016

Last Update Submit

June 11, 2026

Conditions

Carotid Arteries

Keywords

micro-RNA

Outcome Measures

Primary Outcomes (1)

  • expression level of the seven miRNAs of interest

    expression level of the seven miRNAs of interest in the serum and in carotid artery plaques : miR-100, miR-125a, miR-127, miR-133a, miR-145, miR-221

    Day of surgery

Interventions

microRNAOTHER

Extraction of the microRNA using the mirVana miRNA isolation kit and quantification using real-time PCRs

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Adults having to undergo carotid thrombendarteriectomy

You may qualify if:

  • Adults having to undergo carotid thromboendarteriectomy
  • social security coverage
  • provision of study information
  • consent to participation.

You may not qualify if:

  • Previous carotid artery surgery
  • refusal to participate in the study
  • or inability to give consent.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU Amiens

Amiens, 80054, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

carotid artery plaques blood

MeSH Terms

Interventions

MicroRNAs

Intervention Hierarchy (Ancestors)

RNA, AntisenseAntisense Elements (Genetics)Nucleic Acids, Nucleotides, and NucleosidesRNANucleic AcidsRNA, Small UntranslatedRNA, Untranslated

Study Officials

  • Pierre MAITRIAS, PhD

    CHU Amiens

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 15, 2016

First Posted

June 17, 2016

Study Start

March 26, 2015

Primary Completion

February 26, 2018

Study Completion

February 26, 2018

Last Updated

June 12, 2026

Record last verified: 2026-06

Locations

FR(1)