Carotid Web Associated With Cerebral Infarctions

NCT04431609 | Recruiting

• 1 other identifier: CHUBX 2018/40
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

Carotid Web located at the bulb level is a rare condition and is often associated with severe cerebral infarction in the carotid territory. This condition has been described predominantly in the black population. However, limited data are available for the epidemiology of carotid web and often result from selected population studies. It has been shown that the carotid web is a focal intimal dysplasia. Rate of ischemic stroke recurrence is high, even in patients treated with antiplatelet therapy. This subtle lesion is often unknown and misdiagnosed including in stroke unit. We assume that the implementation of a multicentric cohort would allow a comprehensive analysis of the carotid web condition.

Conditions

Carotid Arteries

Keywords

Carotid Web; Cerebral Infarction; Cohort

Outcome Measures

Primary Outcomes (1)

• Number of patients included and validated by the expert committee at the end of the inclusion period

  The missing data concerning clinical data, therapy used and functional prognosis between 3 and 6 months should be \<10%. Each item entered in the eCRF can be answered. The lack of response will be considered as missing data in the patient's file.

  At 3 years

Secondary Outcomes (9)

• Demographics collected at the inclusion

  at the inclusion

• NIHSS score at the admission in the neurological unit

  at the inclusion

• Radiological of the cerebral infarction collected at the inclusion

  Web measurements carried out by 2 experts one month after the inclusion

• Radiological of the cerebral infarction collected one month after the inclusion

  Web measurements carried out by 2 experts one month after the inclusion

• Management of the cerebral infarction in emergency (within 48 hours from stroke onset): Thrombolysis, Thrombectomy, Decompressive hemicraniectomy, Antiplatelet or Anticoagulant treatment

  at the inclusion

Study Arms (1)

CAROtid WEB associated with cerebral infarction

french multicentric cohort that collects retrospectively and prospectively purely observational data on patients with cerebral infarction associated with a carotid web. Diagnostic, therapeutic or follow-up strategies will be at the discretion of the Stroke Unit taking care of the patient.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients over 18 years of age, with imagery available by Angioscanner, Angio-MRI, or arteriography and revealing the presence of a carotid web, with a cerebral infarction or transient ischemic attack in the carotid territory downstream of a lesion of carotid web viewed on a brain MRI.

You may qualify if:

• Age ≥18 years
• Available imaging revealing the presence of a carotid web
• Cerebral infarction or transient ischemic attack in the carotid area downstream of a carotid web lesion.
• Validation of the carotid web by a pair of experts Neurologist and Neuroradiologist
• Agreement of the patient or the support person given after reading the information and non-opposition form

You may not qualify if:

• Age \<18 years
• Patient expressing opposition to be enrolled in the CAROWEB cohort

Sponsors & Collaborators

• University Hospital, Bordeaux: lead

Study Sites (1)

CHU de Bordeaux

Bordeaux, 33076, France

RECRUITING

Related Publications (1)

• Poirette P, Chausson N, Papaxanthos J, Kyheng M, Labreuche J, Smadja D, Gaillard N, Signate A, Joux J, Obadia M, Renou P, Boyer A, Desilles JP, Boulanger M, Robinet-Borgomano E, Zhu F, Richard S, Turpinat C, Landais A, Desal H, Guillon B, Viguier A, Lamy M, Denier C, Lecluse A, Malrain C, Lyoubi A, Holay Q, Bourgeois Q, Chaari D, Olindo S, Marnat G; CAROWEB Investigators. Delay in Carotid Web Diagnosis Remains Common and Associated With an Increased Risk of Stroke Recurrence. Stroke. 2025 Aug;56(8):2091-2100. doi: 10.1161/STROKEAHA.124.050238. Epub 2025 May 12.

  PMID: 40351183 DERIVED

MeSH Terms

Conditions

Cerebral Infarction

Condition Hierarchy (Ancestors)

Brain Infarction; Brain Ischemia; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Stroke; Vascular Diseases; Cardiovascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Central Study Contacts

Stéphane OLINDO, M.D

CONTACT

05 57 82 12 63; stephane.olindo@chu-bordeaux.fr

Aurore CAPELLI, PhD

CONTACT

05 57 82 08 77; aurore.capelli@chu-bordeaux.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 30, 2020
• First Posted: June 16, 2020
• Study Start: June 19, 2019
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: October 6, 2023

Record last verified: 2023-10

Locations

FR (1)