Diagnosis of Pulmonary Hypertension Using Cardiac Magnetic Resonance Images

NCT02790918 | Completed

• 1 other identifier: 2013/290/C
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, study team aim to i) evaluate the accuracy of 3D IVS curvedness for prediction of RV systolic pressure (RVSP), mean pulmonary artery pressure (mPAP) and pulmonary vascular resistance (PVR) with RHC; ii) evaluate the usefulness of 3D IVS curvedness for predicting the response to vasodilator challenge with RHC, in patients clinically suspected or known to have primary PH.

Conditions

Pulmonary Hypertension

Keywords

Pulmonary Hypertension; MRI

Outcome Measures

Primary Outcomes (1)

• First occurrence of cardiovascular event.

  1-Year

Study Arms (2)

Diagnosed Pulmonary Hypertension

Patients will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) and 6MWT.

Other: 6MWT; Other: Cardiovascular Magnetic Resonance Imaging (CMRI)

Healthy Volunteer

Healthy Volunteer will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) and 6MWT.

Other: 6MWT; Other: Cardiovascular Magnetic Resonance Imaging (CMRI)

Interventions

6MWT OTHER

Each patient will also receive 6MWT at cardiovascular rehabilitation and preventive cardiology laboratory. Besides the distance covered in meters or converted measure (such as feet) over 6 minutes, a portable metabolic system is used to measure oxygen uptake during exercise (VO2 testing) for each patient.

Diagnosed Pulmonary Hypertension; Healthy Volunteer

Cardiovascular Magnetic Resonance Imaging (CMRI) OTHER

MRI uses interaction of the magnetic properties of body tissues with strong magnetic fields to create images; for about 1 hour. Several sets of images are needed. No injection of drug or dye will be used for this procedure.

Diagnosed Pulmonary Hypertension; Healthy Volunteer

Eligibility Criteria

• Age: 16 Years - 99 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

30 diagnosed pulmonary hypertension patient will be recruited from primary care clinic and outpatient clinics from the National Heart Centre Singapore. 30 Healthy volunteer control.

You may qualify if:

• Signed informed consent prior to initiation of any study mandated procedure
• Age 16 years or more.
• Patient with clinically suspected or known primary PH belonging to one of the Updated Dana Point Clinical Classification Groups (I-IV)
• No known history of pulmonary hypertension

You may not qualify if:

• Contraindication to MR examination:
• Cardiac pacemaker
• Brain aneurysm or clips
• Electronic implants or prosthesis
• Eye metal foreign body injury
• Severe claustrophobia

Sponsors & Collaborators

• National Heart Centre Singapore: lead

Study Sites (1)

National Heart Centre Singapore

Singapore, 169609, Singapore

Location

Related Publications (1)

• Leng S, Dong Y, Wu Y, Zhao X, Ruan W, Zhang G, Allen JC, Koh AS, Tan RS, Yip JW, Tan JL, Chen Y, Zhong L. Impaired Cardiovascular Magnetic Resonance-Derived Rapid Semiautomated Right Atrial Longitudinal Strain Is Associated With Decompensated Hemodynamics in Pulmonary Arterial Hypertension. Circ Cardiovasc Imaging. 2019 May;12(5):e008582. doi: 10.1161/CIRCIMAGING.118.008582.

  PMID: 31088152 DERIVED

MeSH Terms

Conditions

Hypertension, Pulmonary

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Liang Zhong, PhD

  National Heart Centre Singapore

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 30, 2016
• First Posted: June 6, 2016
• Study Start: May 1, 2013
• Primary Completion: October 1, 2019
• Study Completion: October 1, 2019
• Last Updated: August 4, 2020

Record last verified: 2020-08

Data Sharing

• IPD Sharing: Will not share

Locations

SG (1)