Non-invasive Estimation of Pulmonary Capillary Blood Volume in Pre- and Postcapillary Pulmonary Hypertension - a Pilot Study
Sponsor study identifier
observational
17
1 country
1
Study Start
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
Primary Completion
December 31, 2018
Actual (reported)Study Completion
December 31, 2018
Actual (reported)The aim of the study is to investigate the role of the non-invasive assessment of nitric oxyde (NO) diffusion capacity (DLNO) in the differential diagnosis of different forms of pulmonary hypertension (PH). DLNO alone and in combination with the measurement of carbon monoxide (CO) diffusion capacity (DLCO) may help to differentiate between pre- and postcapillary forms of pulmonary hypertension. This hypothesis is based on the fact that NO has a much higher affinity to hemoglobin as compared to CO and may therefore its decrease may more specifically identify the limiting factors between the alveolar space and the lung capillaries including left heart failure (cardiac edema). As there are no available published data yet to answer this question investigators aim to perform a small pilot study. The results of this study may allow the planning of a prospective study.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2018
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
April 22, 2016
Actual (reported)June 3, 2016
Actual (reported)December 31, 2018
Actual (reported)December 31, 2018
Actual (reported)Difference in DLNO (in mmol/min/kPa) between the two predefined groups (patients with clear precapillary PH (PAWP<12mmHg) vs. clear postcapillary PH (PAWP>18mmHg))
one hour
patients with PH and PAWP\<12mmHg
patients with PH and PAWP\>18mmHg
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
patients with PH
Medical University Graz, Division of Pulmonology
Graz, Styria, 8010, Austria
Horst Olschewski, MD
Medical University of Graz
17 participants (actual enrollment reported by the registry).
First Submitted
April 22, 2016
First Posted
June 3, 2016
Study Start
November 2015
Date type not reportedThis date has not been verified as actual or estimated.
Differential Diagnosis of Pulmonary Hypertension With Automated Image Analysis
Contact the study team to confirm eligibility.
Primary Completion
December 31, 2018
Actual (reported)Study Completion
December 31, 2018
Actual (reported)Last Updated
March 18, 2020
Record last verified: 2020-03
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.
Source retrieved: