The Exercise Capacity and Quality of Life in the Patients With IPAH and Secondary PH

NCT02647060 | Completed

• 1 other identifier: 201511029RINA
• Study Type: observational
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

Pulmonary hypertension (PH) is a progressive disease with high mortality rate, but due to the development of drugs, the prognosis of the disease has improved. However patients still have poor exercise capacity and decrease of the quality of life. Past studies have shown that idiopathic and secondary PH are different in etiology and prognosis. It is necessary to further understand the difference between exercise capacity and quality of life of these two types of patients.

Conditions

Hypertension, Pulmonary

Keywords

cardiopulmonary exercise testing; right ventricle function; cardio output; pulmonary hypertension; quality of life

Outcome Measures

Primary Outcomes (3)

• exercise capacity

  cardiopulmonary exercise testing(using ''MetaMax 3B system, CORTEX Biophysik GmbH'' as the measure system, and the data will present as VO2)

  within 1 months after inclusion

• quality of life

  SF-36

  within 1 months after inclusion

• Functional exercise capacity

  six minutes walk test

  within 1 months after inclusion

Secondary Outcomes (4)

• Cardiac function

  within 1 months after inclusion

• Volume of regular physical activity

  within 1 months after inclusion

• fatigue severity

  within 1 months after inclusion

• body composition

  within 1 months after inclusion

Study Arms (2)

idiopathic pulmonary hypertension

1. diagnose as idiopathic pulmonary arterial hypertension 2. clinical stable over 3 months 3. able to walk and can do bicycle cardiopulmonary exercise testing

secondary pulmonary hypertension

1. diagnose as pulmonary hypertension 2. clinical stable over 3 months 3. able to walk and can do bicycle cardiopulmonary exercise testing

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

pulmonary hypertension, clinical stable, able to walk and can perform cardiopulmonary exercise testing by bicycle

You may qualify if:

• diagnose as pulmonary hypertension
• clinical stable over 3 months
• able to walk and can perform cardiopulmonary exercise testing by bicycle

You may not qualify if:

• acute right heart failure
• sever arrythmia
• the history of exercise induce syncope

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Zhongzheng Dist, 10055, Taiwan

Location

MeSH Terms

Conditions

Hypertension, Pulmonary

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Chien Meng-Yueh, PhD

  School and Graduate Institute of Physical Therapy, National Taiwan University

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 15, 2015
• First Posted: January 6, 2016
• Study Start: January 13, 2016
• Primary Completion: April 1, 2016
• Study Completion: November 19, 2016
• Last Updated: July 11, 2018

Record last verified: 2018-06

Locations

TW (1)