Aerobic Exercise and Cognitive Training in Older Adults
1 other identifier
interventional
78
1 country
1
Brief Summary
The purpose of this study is to examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults. It is hypothesized that the aerobic exercise will potentiate and increase the generalizability of the cognitive training. Importantly, this study will focus on older adults at-risk for mobility disability. This area is of particular importance considering a large percentage of adults are entering old age and therefore likely to suffer from age-related cognitive decline and mobility disability. To address the investigators' research question 60 adults (age 18-89) will be randomized to one of two 12 week intervention groups: 1) Cognitive Training alone (CT) or 2) Aerobic Exercise + Cognitive Training (AE+CT). The aerobic exercise arm of the study will follow the same format shown to improve a broad range of executive functions in older adults in previous research. The cognitive training arm will consists of a popular commercially-available brain fitness program that has demonstrated specific cognitive improvements and high adherence.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Feb 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 1, 2013
CompletedFirst Submitted
Initial submission to the registry
May 25, 2016
CompletedFirst Posted
Study publicly available on registry
June 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2019
CompletedResults Posted
Study results publicly available
June 16, 2020
CompletedNovember 16, 2020
November 1, 2020
6.2 years
May 25, 2016
May 6, 2020
November 12, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Change Executive Language Functions (Category Verbal Fluency)
The Category Verbal Fluency Test is demonstrated to be reliable and valid among adults aged 50 to 89. For Category Verbal Fluency, participants are asked to generate words from a category (e.g., colors) within 60 seconds. A higher change score represents better performance on the outcome.
change from pre and post separated by 12 weeks
Study Arms (2)
Aerobic Exercise + Cognitive Training Group
EXPERIMENTALExercise 3 times a week on a stationary ergometer @ 50-80% of maximal heart rate reserve for 20 minutes to 45 minutes per session; plus 20 minutes of cognitive training using Mindfit program
Cognitive Training Only Group
ACTIVE COMPARATORCognitive Training Only Group. For this arm of the intervention, randomized participants followed the same guidelines as the cognitive component of the AE+CT group but did not partake in aerobic exercise. To equalize contact/monitoring of the groups this group met for the same total duration time as the AE+CT group; however, instead of aerobic exercise, progressive whole body stretching and toning exercises
Interventions
stationary bicycling
20 minutes of cognitive training using Mindfit program
Eligibility Criteria
You may qualify if:
- Right handed
- English speaking
- Aged 18 to 89
- Sedentary as defined by \< 120 min/week of aerobic exercise over prior 3 months
- Non-demented (MMSE 24)
You may not qualify if:
- Severe diabetes requiring insulin
- Cognitive-executive function deficit (MoCA \< 26)
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, 30033, United States
Related Publications (1)
Nocera J, Crosson B, Mammino K, McGregor KM. Changes in Cortical Activation Patterns in Language Areas following an Aerobic Exercise Intervention in Older Adults. Neural Plast. 2017;2017:6340302. doi: 10.1155/2017/6340302. Epub 2017 Mar 6.
PMID: 28367334DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Results Point of Contact
- Title
- Joe Nocera
- Organization
- Atl VA
Study Officials
- PRINCIPAL INVESTIGATOR
Joe R. Nocera, PhD
Atlanta VA Medical and Rehab Center, Decatur, GA
Publication Agreements
- PI is Sponsor Employee
- Yes
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- FED
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 25, 2016
First Posted
June 1, 2016
Study Start
February 1, 2013
Primary Completion
April 1, 2019
Study Completion
June 1, 2019
Last Updated
November 16, 2020
Results First Posted
June 16, 2020
Record last verified: 2020-11
Data Sharing
- IPD Sharing
- Will not share