Exercise, Cognitive Function and Neuroplasticity in Healthy Adults

NCT02994134 | Completed

• 1 other identifier: 20161059
• Study Type: interventional
• Target: 19
• Locations: 1 country
• Sites: 1

Brief Summary

The overall goal of the proposed study is to compare the effects of 4 weeks of moderate or high intensity aerobic exercise on neuroplasticity, cognitive performance and gait and postural control in sedentary healthy adults.

Conditions

Sedentary Lifestyle

Outcome Measures

Primary Outcomes (1)

• Change in cortical synaptic plasticity using transcranial magnetic stimulation (TMS) from baseline to post-exercise.

  Plasticity with TMS

  Baseline, 4 weeks

Study Arms (2)

Moderate intensity exercise.

ACTIVE COMPARATOR

Moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate), 4 times per week for 4 weeks.

Behavioral: Moderate intensity exercise.

High intensity exercise

EXPERIMENTAL

High intensity aerobic exercise intervention (delivered at 65%-90% age-predicted maximal heart rate), 4 times per week for 4 weeks.

Behavioral: High intensity exercise.

Interventions

Moderate intensity exercise. BEHAVIORAL

Moderate intensity aerobic exercise intervention (delivered at 55-64% age-predicted maximal heart rate), 4 times per week for 4 weeks.

Moderate intensity exercise.

High intensity exercise. BEHAVIORAL

High intensity aerobic exercise intervention (delivered at 65-90% age-predicted maximal heart rate), 4 times per week for 4 weeks.

High intensity exercise

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adult males and females aged 18-70 years old
• Primary language is English
• Sedentary (defined as not engaging in purposeful physical activity more than 2 times over the last two months)
• Exercise clearance

You may not qualify if:

• Presence of cognitive, neurologic or orthopedic conditions that could affect performance of the testing and training procedures
• History of migraines.
• History of fainting spells of unknown or undetermined etiology that might constitute seizures
• History of seizures, diagnosis of epilepsy, history of abnormal (epileptiform) EEG or family history of treatment resistant epilepsy
• Any current history of a psychiatric illness
• Any unstable medical condition
• The subject's past medical history, drug dose, history of recent medication changes or duration of treatment, and combination with other CNS active drugs.
• The published TMS guidelines review medications to be considered with TMS (Rossi, Hallett, Rossini, Pascual-Leone, \& Safety of TMS Consensus Group, 2009).
• Any metal in the brain, skull or elsewhere unless approved by the responsible MD
• Any medical devices (i.e. Cardiac pacemaker, deep brain stimulator, medication infusion pump, cochlear implant, vagal nerve stimulator)
• Intracranial lesion
• Substance abuse or dependence within the past six months Subjects who, in the Investigator's opinion, might not be suitable for the study

Sponsors & Collaborators

• University of Miami: lead

Study Sites (1)

University of Miami Miller School of Medicine

Miami, Florida, 33136, United States

Location

MeSH Terms

Conditions

Sedentary Behavior

Interventions

High-Intensity Interval Training

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Joyce R Gomes Osman, PT, PhD

  University of Miami

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 1, 2016
• First Posted: December 15, 2016
• Study Start: September 29, 2017
• Primary Completion: January 21, 2021
• Study Completion: October 31, 2021
• Last Updated: December 8, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)