Sleep and Memory in Children

NCT02785328 | Completed

• 1 other identifier: 69HCL15_0226
• Study Type: interventional
• Target: 71
• Locations: 1 country
• Sites: 1

Brief Summary

Sleep exerts a dual effect on learning: on the one hand, good sleep quality allows good daytime aptitudes leading to knowledge acquisition. On the other hand, sleep after learning is necessary for knowledge consolidation. A key role of sleep has clearly been demonstrated in memory consolidation in adults. Sleep leads to strengthen memory by promoting brain plasticity. Surprisingly, sleep influence on learning stabilization has scarcely been studied during childhood and in children affected by sleep disorders. Yet, sleep disorders concern almost 30% of children and are frequently related to a worsening in academic performances. Classical neuropsychological evaluations of these children, based on daytime learning, often fail to determine cognitive profiles explaining their academic difficulties. The investigators hypothesize that a lack of sleep-dependent consolidation could take an active part in these children's cognitive and academic difficulties. This proposal aims at characterizing interactions between sleep, learning and memory processes that have not been studied in children of elementary school age (6-12 years). The investigators will evaluate sleep-dependent memory consolidation processes in children with sleep disorders before and after treatment and healthy controls. Neuropsychological testing and academic performances will be also evaluated.. The comparison of performances obtained before and after medical treatment, will allow to understand whether normalisation of sleep quality permits the restoration of sleep-dependent memory consolidation.

Conditions

Sleep Apnea; Temporo-central Epilepsy; Narcolepsy; High Intellectual Potential; Healthy Subject

Keywords

Memory; sleep; narcolepsy; apnea; epilepsy

Outcome Measures

Primary Outcomes (4)

• Memory performances

  memory test : Björn Rasch, et al. (2007)

  6 months

• Memory performances

  \- Mirror drawing test : Nissen, et al. (2006).

  6 months

• Memory performances

  \- Word- pairs test : Urbain et al. (2011).

  6 months

• Memory performances

  \- Emotional memory test : Prehn-Kristensen et al. (2009).

  6 months

Secondary Outcomes (22)

• total sleep time (TST)

  3 months and 6 months

• sleep efficiency (sleep time/time on bed)

  3 months and 6 months

• sleep latency (time before sleeping after closing eyes)

  3 months and 6 months

• number of awakenings

  3 months and 6 months

• number of Stage 1

  3 months and 6 months

Study Arms (5)

obstructive sleep apnoea

EXPERIMENTAL

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from obstructive sleep apnoea syndrome.

Other: memory evaluation at V1 and V2 (with treatment)

narcolepsy

EXPERIMENTAL

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from narcolepsy.

Other: memory evaluation at V1 and V2 (with treatment)

BECTS (Benign epilepsy with centro-temporal spikes)

EXPERIMENTAL

The objective of this task is to evaluate the sleep-dependent consolidation abilities before and after treatment in children suffering from BECTS.

Other: memory evaluation at V1 and V2 (with treatment)

high intellectual potential

EXPERIMENTAL

The objective of this task is to evaluate the sleep-dependent consolidation abilities in children with high intellectual potential.

Other: memory evaluation at V1 (without treatment)

healthy children

EXPERIMENTAL

The objective of this task is to evaluate the sleep-dependent consolidation abilities in healthy children.

Other: memory evaluation at V1 and V2 (without treatment)

Interventions

memory evaluation at V1 and V2 (with treatment) OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance. The children receive drug treatment (BECTS and Narcolepsy) or surgical (OSA) as part of their routine care.

BECTS (Benign epilepsy with centro-temporal spikes); narcolepsy; obstructive sleep apnoea

memory evaluation at V1 (without treatment) OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance.

high intellectual potential

memory evaluation at V1 and V2 (without treatment) OTHER

Overnight episodic and procedural memory consolidation performance will be assessed at V1 and V2. The performance will be correlated with sleep data, diurnal neuropsychological assessment and academic performance.

healthy children

Eligibility Criteria

• Age: 6 Years - 12 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• aged between 6 and 12 y
• referred to the HFME for a suspicion of sleep apnea
• narcolepsy
• centro-temporal epilepsy
• high intellectual potential
• children without sleep disorders will be included in the healthy control group.

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Service d'exploration et pathologie du sommeil, Hôpital Femme Mère Enfant, 59 Bd Pinel

Lyon, Auvergne-Rhône-Alpes, 69677, France

Location

MeSH Terms

Conditions

Sleep Apnea Syndromes; Narcolepsy; Apnea; Epilepsy

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases; Disorders of Excessive Somnolence; Mental Disorders; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Brain Diseases; Central Nervous System Diseases

Study Officials

• Patricia FRANCO, MD PHD

  Service d'exploration et pathologie du sommeil Hôpital Femme Mère Enfant, 59 bd Pinel 69677 BRON Cedex

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 20, 2016
• First Posted: May 27, 2016
• Study Start: February 1, 2016
• Primary Completion: May 29, 2018
• Study Completion: May 29, 2018
• Last Updated: March 21, 2019

Record last verified: 2019-03

Locations

FR (1)