Role of the Posterior Parietal Cortex in the Processing of Sensory Information

NCT03386188 | Terminated

• 2 other identifiers: 2014_322014-A01507-40
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

Although the primary motor cortex is considered has the common final pathway of motor commands, it is influenced by several structures as, for example, the premotor cortex and the posterior parietal cortex which are involved in motor planning and programming and which integrates movement-induced sensory impute (parieto-frontal circuits). Several studies have shown that there are some direct functional connections between the premotor cortex and the posterior parietal cortex and from these two regions to the primary motor cortex. The posterior parietal cortex can then be considered as a sensorimotor interface whose function in planification and motor control of upper limb is well demonstrated. The hypothesis is that the posterior parietal cortex could participate to the modulation of motor cortex excitability by proprioceptive sensory inputs namely long latency afferent inhibition and afferent induced facilitation.

Conditions

Healthy Subject

Outcome Measures

Primary Outcomes (1)

• Afferent induced facilitation

  Motor cortex facilitation following median nerve stimulation at interstimulus intervals of 70ms

  Baseline

Secondary Outcomes (1)

• Interaction between long latency afferent inhibition and long latency intracortical inhibition (LICI)

  Baseline

Study Arms (1)

Healthy arm

EXPERIMENTAL

posterior parietal cortex (PPC) transitory inactivation

Device: Transcranial Magnetic Stimulation (TMS); Device: Electrical Muscle Activity (EMG)

Interventions

Transcranial Magnetic Stimulation (TMS) DEVICE

Transitory inactivation of the posterior parietal cortex and measure of sensorimotor integration.

Healthy arm

Electrical Muscle Activity (EMG) DEVICE

Electrodes for the collection of EMG activity will be glued on the skin next to the first interosseus dorsalis muscle, the Abductor digiti minimi, the Extensor carpi radialis and the Abductor pollicis brevis. EMG signals will be stored on computer for off-line analysis using Signal © software (Cambridge Electronic Design, Cambridge, UK)

Healthy arm

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Right handed
• No neurological troubles
• Informed consent signed
• Affiliated to a social security

You may not qualify if:

• Psychiatric antecedent
• Neurological disease
• Contra-indication to TMS
• Under psychiatric treatment
• Pregnancy
• Contra-indication to MRI

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hôpital Roger Salengro, CHRU de Lille

Lille, France

Location

MeSH Terms

Interventions

Transcranial Magnetic Stimulation; Electromyography

Intervention Hierarchy (Ancestors)

Magnetic Field Therapy; Therapeutics; Electrodiagnosis; Diagnostic Techniques and Procedures; Diagnosis; Myography

Study Officials

• Philippe Derambure, MD, PhD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 14, 2017
• First Posted: December 29, 2017
• Study Start: January 8, 2016
• Primary Completion: July 18, 2021
• Study Completion: July 18, 2021
• Last Updated: April 22, 2026

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)