Epidemiology of Risk Factors for Hospital-acquired Pneumonia (HAP) in Intensive Care Unit (ICU) Patients

NCT02779933 | Completed

• 1 other identifier: 63/16
• Study Type: observational
• Target: 310
• Locations: 0 countries
• Sites: N/A

Brief Summary

A retrospective, observational study compiled data from all consecutively admitted patients older than 18 years at ICU University Hospital in Olomouc in the period from 1 January 2011 to 31 December 2015 who fulfilled the criteria of HAP. The aim was to determine the severity of the specific risk factors of early and late HAP. Risk factors were divided into factors from the patient and from the hospitalization. Furthermore, an assessment of their relationship to mortality.

Conditions

Ventilator-Associated Pneumonia

Keywords

Hospital-acquired Pneumonia; Epidemiology; Risk Factors

Outcome Measures

Primary Outcomes (1)

• 30-day mortality (non modifiable HAP risk factor)

  Yes/No assessment

  30 days

Secondary Outcomes (24)

• Duration of mechanical ventilation before onset of HAP (non modifiable HAP risk factor)

  7 days

• Duration of hospital stay before onset of HAP (non modifiable HAP risk factor)

  7 days

• Repeated transport of the patient from the ICU (non modifiable HAP risk factor)

  30 days

• Implementation of physiotherapy before onset of HAP (non modifiable HAP risk factor)

  7 days

• Intolerance of enteral nutrition before onset of HAP (non modifiable HAP risk factor)

  7 days

Interventions

Epidemiology od HAP OTHER

no intervention

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

The study included patients hospitalized in the ICU Department of Anesthesiology and Intensive Care Medicine, UH Olomouc. On inclusion did not affect the method of ensuring lower airways (invasive/non-invasive) or results (positivity/negativity) taken microbiological samples from the lower airways (endobronchial aspirate or bronchoalveolar lavage) as approximately one third of samples can be microbiologically negative even when overt bronchopneumonia. Patient cohort consisted of all patients older than 18 years who met the clinical criteria and HAP were consecutively admitted to the ICU.

You may qualify if:

• Hospital-Acquired Pneumonia
• Intensive Care patient
• X-ray signs of pneumonia

You may not qualify if:

• Age less than 18 years
• Negative culture findings in the airways
• Low quantity of culture findings

Sponsors & Collaborators

• University Hospital Olomouc: lead

Related Publications (1)

• Uvizl R, Kolar M, Herkel T, Vobrova M, Langova K. Possibilities for modifying risk factors for the development of hospital-acquired pneumonia in intensive care patients: results of a retrospective, observational study. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2017 Sep;161(3):303-309. doi: 10.5507/bp.2017.019. Epub 2017 Apr 26.

  PMID: 28461706 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

endotracheal aspirate

MeSH Terms

Conditions

Pneumonia, Ventilator-Associated; Healthcare-Associated Pneumonia

Condition Hierarchy (Ancestors)

Cross Infection; Infections; Pneumonia; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Radovan Uvizl

  UH Olomouc, Czech Republic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MUDr., Ph.D.

Study Record Dates

• First Submitted: May 12, 2016
• First Posted: May 23, 2016
• Study Start: January 1, 2011
• Primary Completion: December 1, 2015
• Study Completion: May 1, 2016
• Last Updated: May 23, 2016

Record last verified: 2016-05

Data Sharing

• IPD Sharing: Will share