The National Center for Testing Treatments in Chronic Spinal Cord and Traumatic Brain Injury

NCT02769416 | Enrolling By Invitation

• 1 other identifier: HSC-MS-15-0705
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

The NCTT is a prospective, multicenter, observational research network for subjects with chronic spinal cord and/or chronic traumatic brain injury.

Conditions

Spinal Cord Injury; Traumatic Brain Injury

Keywords

spinal cord injury; traumatic brain injury

Outcome Measures

Primary Outcomes (2)

• International Standard Neurological Classification of Spinal Cord Injury

  functional ability (sensory and motor) for spinal cord injury subjects

  greater than 6 months post-injury

• Disability Rating Scale

  functional outcome scale for brain injury subjects

  greater than 6 months post-injury

Study Arms (2)

Spinal Cord and Traumatic Brain Injury Subjects

Patients with a history of spinal cord and/or traumatic brain injury will provide data and samples so that they may be queried for interventional studies.

Other: Data and sample repository

Family Members and Healthy Volunteers

Healthy volunteer controls or family members may be enrolled for identification of genetic mutations.

Other: Data and sample repository

Interventions

Data and sample repository OTHER

Subjects with spinal cord and/or traumatic brain injury, family members and healthy volunteers will provide data and samples.

Family Members and Healthy Volunteers; Spinal Cord and Traumatic Brain Injury Subjects

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Chronic spinal cord and traumatic brain injury patients, family members, and healthy vounteers

You may qualify if:

• History of spinal cord injury and/or brain injury
• Able to provide HIPAA authorization to share prior medical records/imaging
• Age 18 and older.

You may not qualify if:

• Life expectancy less than 6 months, vegetative state or co-existing disease or other characteristic that precludes appropriate diagnosis of spinal cord or brain injury.
• Other condition that, in the opinion of the site investigator, would interfere with adherence to study requirements.
• Inability or unwillingness of subject or legal guardian/representative to give informed consent (e.g., ward of the state).

Sponsors & Collaborators

• The University of Texas Health Science Center, Houston: lead

Study Sites (1)

The University of Texas Health Science Center at Houston

Houston, Texas, 77030, United States

Location

Biospecimen

Retention: SAMPLES WITH DNA

Blood, urine, and saliva

MeSH Terms

Conditions

Spinal Cord Injuries; Brain Injuries, Traumatic

Condition Hierarchy (Ancestors)

Spinal Cord Diseases; Central Nervous System Diseases; Nervous System Diseases; Trauma, Nervous System; Wounds and Injuries; Brain Injuries; Brain Diseases; Craniocerebral Trauma

Study Officials

• Georgene Hergenroeder, PhD

  UTHealth

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Study Director, PI, Associate Professor

Study Record Dates

• First Submitted: November 19, 2015
• First Posted: May 11, 2016
• Study Start: December 1, 2015
• Primary Completion (Estimated): December 1, 2035
• Study Completion (Estimated): December 1, 2035
• Last Updated: August 7, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)