The Relationship Between White Matter Hyperintensity With Cognition and Emotion
1 other identifier
observational
200
1 country
1
Brief Summary
White matter hyperintensity (WMH) has been found to be related with cognitive and emotional dysfunction. A presumed mechanism is that WMH disrupts the structural connectivity within a large-scale brain network, thereby impairing the brain's ability to integrate the neural processes efficiently. It is not yet clear, what the pattern of brain network disruption relates to WMH and how the brain network disruption induced by WMH has an effect on cognition and emotion performance. Using multi-model magnetic resonance imaging (MRI) techniques, we aimed to explore the mechanisms of cognitive decline and depression related with brain network dysfunction in patients with WMH, and to provide objective imaging marker for early diagnosis and prevention of WMH associated cognitive decline and depression.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2014
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2014
CompletedFirst Submitted
Initial submission to the registry
May 2, 2016
CompletedFirst Posted
Study publicly available on registry
May 4, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2019
CompletedJune 14, 2017
June 1, 2017
5.9 years
May 2, 2016
June 10, 2017
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Fazekas Scale of white matter hyperintensity
1 year
Mini-Mental State Examination (MMSE)
1 year
Hamilton Depression Scale (HAMD)
1 year
Study Arms (2)
Control
White matter hyperintensity
Eligibility Criteria
aged patients with white matter hyperintensity
You may qualify if:
- white matter hyperintensity visible on T2 fluid-attenuated inversion recovery images;
- age between 35 to 80 years;
- without stroke lesion (except lacunar infarction) on current diffusion weighted images;
- without a history of multiple sclerosis, Alzheimer's disease, Parkinson's disease and head trauma.
You may not qualify if:
- white matter lesions of nonvascular origin (immunological-demyelinating, metabolic, toxic, infectious, other);
- intracranial hemorrhage;
- with severe head motion on magnetic resonance images
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
The 2nd Affiliated Hospital of Zhejiang University, School of Medicine,
Hangzhou, Zhejiang, 310009, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Chief,Department of Radiology,The 2nd Affiliated Hospital of Zhejiang University, School of Medicine
Study Record Dates
First Submitted
May 2, 2016
First Posted
May 4, 2016
Study Start
January 1, 2014
Primary Completion
December 1, 2019
Study Completion
December 1, 2019
Last Updated
June 14, 2017
Record last verified: 2017-06