Connectomics in Psychiatric Classification of Bipolar Disorder and Schizophrenia
1 other identifier
observational
220
1 country
1
Brief Summary
Washington University Early Recognition Center is conducting a research study to examine brain functional connectivity and network patterns in participants with bipolar disorder and schizophrenia.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Sep 2014
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
September 1, 2014
CompletedFirst Submitted
Initial submission to the registry
June 17, 2015
CompletedFirst Posted
Study publicly available on registry
April 29, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2019
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2019
CompletedFebruary 8, 2021
February 1, 2021
4.9 years
June 17, 2015
February 3, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
MRI Brain Imaging
The current project aims to uncover latent, homogenous, connectivity phenotypes using neuroimaging tools, which are free from the limitations of traditional diagnostic boundaries, and which correlate with clinical characteristics. The investigator will use resting state functional connectivity MRI (rs-fcMRI), diffusion MRI (dMRI) and tract-based spatial statistics (TBSS) to identify brain signatures that cut across schizophrenia (SZ) and bipolar (BP).
within one month of study enrollment
Secondary Outcomes (2)
DNA testing through saliva
within one month of study enrollment
Hair sample for cortisol measurement
within one month of study enrollment
Study Arms (3)
Control
Individuals between 18-30 years old No diagnosis of Bipolar Disorder or Schizophrenia No intervention used
Bipolar Disorder
Individuals between 18-30 years old Diagnosis of Bipolar Disorder No intervention used
Schizophrenia
Individuals between 18-30 years old Diagnosis of Schizophrenia or Schizoaffective Disorder No intervention used
Interventions
Eligibility Criteria
Individuals between the ages of 18-30 with a diagnosis of Bipolar Disorder or Schizophrenia
You may qualify if:
- Between ages 18-30
You may not qualify if:
- Head Injury
- Unstable Medical Condition
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Washington University School of Medicine
St Louis, Missouri, 63110, United States
Biospecimen
saliva
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Daniel Mamah
Washington University School of Medicine
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
June 17, 2015
First Posted
April 29, 2016
Study Start
September 1, 2014
Primary Completion
August 1, 2019
Study Completion
August 1, 2019
Last Updated
February 8, 2021
Record last verified: 2021-02
Data Sharing
- IPD Sharing
- Will not share