Comparison of the Number of Oocytes Obtained Between Chinese and Caucasian Women in IVF Treatment

NCT02748278 | Completed DMC

• 1 other identifier: UW 15-547
• Study Type: observational
• Target: 192
• Locations: 1 country
• Sites: 1

Brief Summary

IVF is a well-established method to treat various causes of infertility. Some studies have suggested that ethnicity affects the success of IVF. This is a prospective study involving two tertiary IVF units in Hong Kong and Australia. The IVF outcome between Chinese and Caucasians will be compared.

Conditions

Subfertility

Keywords

subfertility; In-vitro fertilization

Outcome Measures

Primary Outcomes (1)

• Number of oocytes obtained

  Number of oocytes obtained

  17 days

Secondary Outcomes (12)

• Number of follicles smaller than 14, 16mm and larger than 18mm in diameter on day 8 and day of hCG

  8 and day of hCG

• Duration of recombinant FSH

  15 days

• Dosage of recombinant FSH

  15 days

• Serum estradiol levels on day 9 and day of hCG

  9 and day of hCG

• Serum FSH levels on day 9 and day of hCG

  9 and day of hCG

Interventions

Transvaginal ultrasound-guided oocyte retrieval PROCEDURE

Transvaginal ultrasound-guided oocyte retrieval will be performed 34-36 hours after hCG injection.

Embryo transfer PROCEDURE

One or two embryos will be replaced on day 2-5 after oocyte retrieval.

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Women undergoing IVF or intracytoplasmic sperm injection (ICSI) treatment in the two study sites.

You may qualify if:

• Women age 18-36 years old
• Body weight \>60Kg
• Total antral follicle count \>=7 and ≤ 20 i.e. not poor ovarian reserve based on Bologna criteria
• Chinese women in the HK centre and Caucasian women (defined as originating from the United Kingdom, Europe or United States of America, excluding the Middle East) in the Australian centre
• Written informed consent

You may not qualify if:

• Mixed race/ ethnicity
• History of ovarian surgery
• Body mass index \>35 kg/m2
• \>2 previous stimulated IVF cycles
• History of ovarian hyperstimulation syndrome in previous stimulated IVF cycles
• Polycystic ovary syndrome or total antral follicle count \>20

Sponsors & Collaborators

• The University of Hong Kong: lead
• The University of New South Wales: collaborator

Study Sites (1)

Department of Obstetrics and Gynaecology

Hong Kong, Hong Kong, China

Location

Related Publications (1)

• Ko JKY, Kan A, Leung P, Lee VCY, Li RHW, Ledger W, Ng EHY. Comparison of the number of oocytes obtained after ovarian stimulation between Chinese and Caucasian women undergoing in vitro fertilization using a standardized stimulation regime. J Ovarian Res. 2021 Dec 11;14(1):175. doi: 10.1186/s13048-021-00928-4.

  PMID: 34895264 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

Blood will be saved for genetic study if there is significant difference in the number of oocytes obtained between Chinese and Caucasian women.

MeSH Terms

Conditions

Infertility

Interventions

Embryo Transfer

Condition Hierarchy (Ancestors)

Genital Diseases; Urogenital Diseases

Intervention Hierarchy (Ancestors)

Reproductive Techniques, Assisted; Reproductive Techniques; Therapeutics; Investigative Techniques

Study Officials

• Ernest HY Ng

  Department of Obstetrics and Gynaecology, 6/F, Professorial Block, Queen Mary Hospital, 102 Pokfulam Road, Hong Kong

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2016
• First Posted: April 22, 2016
• Study Start: October 1, 2016
• Primary Completion: April 30, 2020
• Study Completion: December 30, 2020
• Last Updated: April 29, 2021

Record last verified: 2020-07

Locations

CN (1)