Early Life Exposures in Agriculture

NCT02743481 | Completed

• 2 other identifiers: 99991609516-C-N095
• Study Type: observational
• Target: 60,000
• Locations: 1 country
• Sites: 1

Brief Summary

Background: The Agricultural Health Study (AHS) studied farmers and their spouses in North Carolina and Iowa. It also included people who worked with pesticides in Iowa. They answered a questionnaire and gave data about their children born since 1975. Researchers want to link this data to public data like birth and death certificates. They want to study how early life exposures to farms are linked to cancer and other bad health outcomes. Objective: To study data to find links between early life farm exposure and negative health outcomes. Eligibility: There will be no human subjects. Design: Researchers will get public data in the two study states. This will come from things like: Birth certificates Driver s licenses Voter registration Death certificates Based on these plus the AHS data, they will create a study group. It will be called Early Life Exposure in Agriculture (ELEA). Researchers will link ELEA data to cancer data. This will identify prevalence of cancer. They will study parents answers on the AHS. The topics include farm practices and pesticide use. They will determine ELEA exposure to pesticides. Researchers will analyze the cancer and pesticide results and look for links.

Conditions

Testicular Cancer; Leukemia; Lymphoma; Brain Cancer

Keywords

Pesticide; Agriculture; Cancer; Childhood; Leukemia

Outcome Measures

Primary Outcomes (2)

• Cancer incidence

  Cancer incidence

  Birth through 2014

• Mortality

  Death

  Birth through 2014

Eligibility Criteria

• Age: 7 Years - 46 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Offspring of Agricultural Health Study (AHS) cohort members (farmers and their spouses residing in North Carolina and Iowa, and commercial pesticide applicators residing in Iowa).

You may qualify if:

• children born to Agricultural Health Study (AHS) participants from 1975-2009.
• individuals identified through questionnaire or through the probabilistic and deterministic match to the birth registries as being the offspring of the AHS participants.

Sponsors & Collaborators

• National Cancer Institute (NCI): lead

Study Sites (1)

National Cancer Institute (NCI)

Bethesda, Maryland, 20892, United States

Location

MeSH Terms

Conditions

Testicular Neoplasms; Leukemia; Lymphoma; Brain Neoplasms; Neoplasms

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Genital Neoplasms, Male; Urogenital Neoplasms; Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Male Urogenital Diseases; Endocrine System Diseases; Testicular Diseases; Gonadal Disorders; Neoplasms by Histologic Type; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Central Nervous System Neoplasms; Nervous System Neoplasms; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Officials

• Laura Beane-Freeman

  National Cancer Institute (NCI)

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: NIH
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 14, 2016
• First Posted: April 19, 2016
• Study Start: April 14, 2016
• Primary Completion: April 15, 2020
• Study Completion: April 15, 2020
• Last Updated: April 20, 2020

Record last verified: 2020-04

Locations

US (1)