Key Insights

Highlights

Success Rate

78% trial completion

Published Results

34 trials with published results (19%)

Research Maturity

91 completed trials (51% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

14.4%

26 terminated out of 180 trials

Success Rate

77.8%

-8.8% vs benchmark

Late-Stage Pipeline

6%

10 trials in Phase 3/4

Results Transparency

37%

34 of 91 completed with results

Key Signals

34 with results78% success26 terminated

Data Visualizations

Phase Distribution

142Total
Not Applicable (42)
Early P 1 (7)
P 1 (53)
P 2 (30)
P 3 (8)
P 4 (2)

Trial Status

Completed91
Recruiting35
Terminated26
Active Not Recruiting9
Withdrawn6
Unknown5

Trial Success Rate

77.8%

Benchmark: 86.6%

Based on 91 completed trials

Clinical Trials (180)

Showing 20 of 20 trials
NCT06991101Phase 2Recruiting

Ruxolitinib With Radiation and Temozolomide Compared to Radiation and Temozolomide for Newly Diagnosed Glioblastoma

NCT07374692Completed

Observational Study of Responses to Treatments in Advanced Central Nervous System (CNS) Tumors

NCT07326566Phase 2Recruiting

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

NCT07416188Phase 1Recruiting

Novel Indenoisoquinolone CMYC/TOPOISOMERASE 1 Inhibitor (LMP744) in Recurrent Glioblastoma

NCT07827001RecruitingPrimary

PilotStudyAssessSafeActiveSurveillancApproachLocalThe Pa w/BrainMetsUndergoinCNSPenetratSystemicThe

NCT04899908Phase 2RecruitingPrimary

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

NCT02851706CompletedPrimary

Natural History of and Specimen Banking for People With Tumors of the Central Nervous System

NCT03170141Phase 1Terminated

Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme

NCT02691923Phase 2Active Not RecruitingPrimary

Diagnostic Performance of Fluorescein as an Intraoperative Brain Tumor Biomarker

NCT03972514Active Not Recruiting

Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.

NCT06580002Phase 2Recruiting

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

NCT01892397Not ApplicableActive Not RecruitingPrimary

Pilot Study of Optune (NovoTTF-100A) for Recurrent Atypical and Anaplastic Meningioma

NCT07210632Early Phase 1RecruitingPrimary

Window Trial of Fluorescently Labeled Nivolumab-IRDye800 (Nivo800) in High Grade Glioma (HGG)

NCT07493447Early Phase 1Recruiting

Pilot Study Evaluating Panitumumab-IRDye800 as an Optical Imaging Agent to Detect Intracranial Lesions During Neurosurgical Procedures

NCT07628647Not ApplicableNot Yet RecruitingPrimary

Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being

NCT07629089Phase 1Not Yet RecruitingPrimary

VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 Mutations

NCT04222309Phase 1Suspended

Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)

NCT05979064Not ApplicableRecruiting

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

NCT03630289Not ApplicableCompleted

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

NCT02861898Phase 1Recruiting

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

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