METSLIVER
The Influence of Metabolic Syndrome and Circulating Bile Acid Levels on the Development of Hepatocellular Carcinoma and Biliary Tract Cancers
Sponsor study identifier
observational
124
1 country
1
Study Start
March 2016
Actual (reported)Primary Completion
October 2017
Actual (reported)Study Completion
December 2018
Actual (reported)Increasing rates of highly malignant hepatocellular carcinoma (HCC) and biliary tract cancers (GBTC) observed in Western populations may be related to obesogenic lifestyle factors and their metabolic consequences, such as metabolic syndrome (MetS), inflammation and altered production of bile acids (BA). Such lifestyle behaviours may induce changes in the gut microflora which in turn affect BA profiles, increasing their carcinogenicity. Some elevated BA may be oncogenic in exposed liver, bile ducts and gall bladder. Vertical sleeve gastrectomy may change bile acid composition. The aims of this study are:
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 2018
Actual (reported)Click on a node to explore related trials.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 2016
Actual (reported)April 1, 2016
Actual (reported)April 6, 2016
Actual (reported)October 2017
Actual (reported)December 2018
Actual (reported)Blood bile acids (micromols per liter)
at one year after surgery
Hepatic FXR expression
At baseline
Patients with morbid obesity and vertical sleeve gastrectomy
Patients who undergo vertical sleeve gastrectomy
AP-HP, Antoine Béclère Hospital
Clamart, 92141, France
Feces, blood, liver biopsy
Gabriel PERLEMUTER, MD, PhDi
Assistance Publique - Hôpitaux de Paris, Antoine Béclère Hospital
124 participants (actual enrollment reported by the registry).
First Submitted
April 1, 2016
First Posted
April 6, 2016
Study Start
March 2016
Actual (reported)Perfusion and Dual Energy Computer Tomography in Hepatocellular Carcinoma
Contact the study team to confirm eligibility.
Primary Completion
October 2017
Actual (reported)Study Completion
December 2018
Actual (reported)Last Updated
December 17, 2019
Record last verified: 2019-12
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Source: ClinicalTrials.gov.
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