Dual Energy CT: A New Method for Better Dose Calculation in Proton Beam Therapy

NCT02722109 | Terminated

• 1 other identifier: VEK52217
• Study Type: observational
• Target: 14
• Locations: 0 countries
• Sites: N/A

Brief Summary

Researchers want to compare proton stopping ratios, used for proton beam therapy planning, calculated based on single energy CT and dual energy CT images; with the intension of improve upon the proton range determination.

Conditions

Cancer

Outcome Measures

Primary Outcomes (1)

• Stopping power ratio differences

  For each patient the stopping power will be calculated based on both single and dual energy CT. The treatment of the patient will not be affected in any way of this study, the patient will receive the same treatment whether or not the patient volunteers to participate in this study. And the outcome of the calculations performed in this study will have no influence for the patient. The calculations of the stopping power differences for each patient will as far as possible be done right after acquisition of the CT images, but the exact time point is not important. We will set as a deadline that the calculation for each patient is done within 2 months of acquisition of the CT images of the patient. The entire study will be finished within 2 years, and the results will be tried published in a peer-reviewed journal.

  2 months

Interventions

No intervention OTHER

No intervention will be done

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

* Patients with a identified tumor referred to curativ intended external beam radiotherapy * Patients, for who are scheduled for a control CT scan during their treatment course * Patients above 18 years of age * Participation will take place on a voluntary basis It is estimated that annually around 1,000 patients will meet the above inclusion criteria

You may qualify if:

• Cancer patients who are scheduled for a control CT scan

You may not qualify if:

• Under 18 years of age

Sponsors & Collaborators

• Aarhus University Hospital: lead

Related Publications (11)

• Engelsman M, Schwarz M, Dong L. Physics controversies in proton therapy. Semin Radiat Oncol. 2013 Apr;23(2):88-96. doi: 10.1016/j.semradonc.2012.11.003.

  PMID: 23473685 BACKGROUND

• Knopf AC, Lomax A. In vivo proton range verification: a review. Phys Med Biol. 2013 Aug 7;58(15):R131-60. doi: 10.1088/0031-9155/58/15/R131. Epub 2013 Jul 17.

  PMID: 23863203 BACKGROUND

• Johnson TR. Dual-energy CT: general principles. AJR Am J Roentgenol. 2012 Nov;199(5 Suppl):S3-8. doi: 10.2214/AJR.12.9116.

  PMID: 23097165 BACKGROUND

• Hunemohr N, Krauss B, Tremmel C, Ackermann B, Jakel O, Greilich S. Experimental verification of ion stopping power prediction from dual energy CT data in tissue surrogates. Phys Med Biol. 2014 Jan 6;59(1):83-96. doi: 10.1088/0031-9155/59/1/83. Epub 2013 Dec 12.

  PMID: 24334601 BACKGROUND

• Bourque AE, Carrier JF, Bouchard H. A stoichiometric calibration method for dual energy computed tomography. Phys Med Biol. 2014 Apr 21;59(8):2059-88. doi: 10.1088/0031-9155/59/8/2059. Epub 2014 Apr 2.

  PMID: 24694786 BACKGROUND

• Hall EJ. Henry S. Kaplan Distinguished Scientist Award 2003. The crooked shall be made straight; dose-response relationships for carcinogenesis. Int J Radiat Biol. 2004 May;80(5):327-37. doi: 10.1080/09553000410001695895.

  PMID: 15223765 BACKGROUND

• Paganetti H. Range uncertainties in proton therapy and the role of Monte Carlo simulations. Phys Med Biol. 2012 Jun 7;57(11):R99-117. doi: 10.1088/0031-9155/57/11/R99. Epub 2012 May 9.

  PMID: 22571913 RESULT

• Hudobivnik N, Schwarz F, Johnson T, Agolli L, Dedes G, Tessonnier T, Verhaegen F, Thieke C, Belka C, Sommer WH, Parodi K, Landry G. Comparison of proton therapy treatment planning for head tumors with a pencil beam algorithm on dual and single energy CT images. Med Phys. 2016 Jan;43(1):495. doi: 10.1118/1.4939106.

  PMID: 26745942 RESULT

• Hansen DC, Seco J, Sorensen TS, Petersen JB, Wildberger JE, Verhaegen F, Landry G. A simulation study on proton computed tomography (CT) stopping power accuracy using dual energy CT scans as benchmark. Acta Oncol. 2015;54(9):1638-42. doi: 10.3109/0284186X.2015.1061212. Epub 2015 Jul 29.

  PMID: 26219959 RESULT

• Yang M, Virshup G, Clayton J, Zhu XR, Mohan R, Dong L. Theoretical variance analysis of single- and dual-energy computed tomography methods for calculating proton stopping power ratios of biological tissues. Phys Med Biol. 2010 Mar 7;55(5):1343-62. doi: 10.1088/0031-9155/55/5/006. Epub 2010 Feb 10.

  PMID: 20145291 RESULT

• Schneider U, Pedroni E, Lomax A. The calibration of CT Hounsfield units for radiotherapy treatment planning. Phys Med Biol. 1996 Jan;41(1):111-24. doi: 10.1088/0031-9155/41/1/009.

  PMID: 8685250 RESULT

MeSH Terms

Conditions

Neoplasms

Study Officials

• Cai Grau, Professor

  Aarhus University Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: M.Sc., PhD student

Study Record Dates

• First Submitted: March 15, 2016
• First Posted: March 29, 2016
• Study Start: August 1, 2016
• Primary Completion: December 1, 2017
• Study Completion: December 1, 2017
• Last Updated: January 10, 2018

Record last verified: 2018-01

Data Sharing

• IPD Sharing: Will not share