NCT02708134

Brief Summary

This is a prospective, observational, multi-center cohort study of pediatric cardiac arrests. The purpose of the study is to determine the association between chest compression mechanics (rate, depth, flow fraction, compression release) and patient outcomes. In addition, the investigators will determine the association of post cardiac arrest care with patient outcomes.

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
7,000

participants targeted

Target at P75+ for all trials

Timeline
44mo left

Started May 2016

Longer than P75 for all trials

Geographic Reach
15 countries

61 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress73%
May 2016Jan 2030

First Submitted

Initial submission to the registry

January 28, 2016

Completed
2 months until next milestone

First Posted

Study publicly available on registry

March 15, 2016

Completed
2 months until next milestone

Study Start

First participant enrolled

May 2, 2016

Completed
13.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2030

Last Updated

October 2, 2025

Status Verified

September 1, 2025

Enrollment Period

13.7 years

First QC Date

January 28, 2016

Last Update Submit

September 29, 2025

Conditions

Keywords

Chest compressionsCardiopulmonary ResuscitationPediatric

Outcome Measures

Primary Outcomes (1)

  • Aggregate score composed of American Heart Association (AHA) recommended depth, rate, and chest compression fraction during CPR

    Primary outcome: "Guideline-compliant CPR" which will be determined by an aggregate score comprised of the following three components: depth, rate, and chest compression fraction. The three components will be analyzed in 30 and 60 second epochs. "Guideline-compliant CPR" requires that each component meet the following criteria: 1) Age-determined American Heart Association (AHA) guideline recommended depth; 2) rate ≥ 90 and ≤ 120 CC/min; and 3) CC Fraction ≥ 0.80. Depth, rate, and CC Fraction will be calculated for each epoch and an aggregate score will be assigned. The primary analysis will be performed on that total score.

    10 Years

Study Arms (1)

Pediatric Cardiac Arrests

Pediatric cardiac arrests requiring chest compressions for at least 1 minute managed at clinical centers identified as part of standard clinical operations.

Eligibility Criteria

Age0 Years - 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Data will be collected from pediatric cardiac arrest events as part of standard clinical operations.

You may qualify if:

  • Patient received chest compressions for at least 1 minute
  • Patient between gestational age ≥37 weeks and 18 years of age

You may not qualify if:

  • Patient on veno-arterial extracorporeal membrane oxygenation (ECMO) therapy at beginning of CPR event

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (61)

Kaiser Permanente

Los Angeles, California, 90027, United States

RECRUITING

Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States

RECRUITING

Valley Children's Hospital

Madera, California, 93636, United States

RECRUITING

Chldren's Hospital of Orange County

Orange, California, 92868, United States

RECRUITING

Stanford University

Palo Alto, California, 94304, United States

RECRUITING

Rady Children's Hospital

San Diego, California, 92123, United States

RECRUITING

Children's Colorado

Aurora, Colorado, 80045, United States

RECRUITING

Nemours Children's Hospital

Wilmington, Delaware, 19803, United States

RECRUITING

All Children's Hospital

St. Petersburg, Florida, 33701, United States

NOT YET RECRUITING

Children's Healthcare of Atlanta (CHOA)

Atlanta, Georgia, 30322, United States

RECRUITING

Lurie Children's (Children's Hospital of Chicago)

Chicago, Illinois, 60611, United States

RECRUITING

University of Chicago, Comer Children's Hospital

Chicago, Illinois, 60637, United States

RECRUITING

Riley Hospital for Children

Indianapolis, Indiana, 46202, United States

RECRUITING

University of Iowa Stead Family Children's Hospital

Iowa City, Iowa, 52242, United States

RECRUITING

Kentucky Children's Hospital

Lexington, Kentucky, 40536, United States

RECRUITING

The Johns Hopkins Hospital

Baltimore, Maryland, 21287, United States

RECRUITING

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

RECRUITING

Boston Children's

Boston, Massachusetts, 02115, United States

RECRUITING

St. Louis Children's Hospital

St Louis, Missouri, 63110, United States

RECRUITING

Nebraska Medical Center

Omaha, Nebraska, United States

RECRUITING

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

RECRUITING

Albany Medical Center

Albany, New York, 12208, United States

RECRUITING

Mount Sinai Kravis Children's Hospital

New York, New York, 10029, United States

RECRUITING

Morgan Stanley Children's Hospital

New York, New York, 10032, United States

RECRUITING

Cohen Children's Medical Center

Queens, New York, 11040, United States

RECRUITING

Stony Brook University Hospital

Stony Brook, New York, 11794, United States

RECRUITING

Upstate Golisano Children's Hospital

Syracuse, New York, 13210, United States

RECRUITING

University of North Carolina

Chapel Hill, North Carolina, 27514, United States

RECRUITING

Akron Children's

Akron, Ohio, 44308, United States

RECRUITING

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States

RECRUITING

Nationwide Children's Hospital

Columbus, Ohio, 43205, United States

RECRUITING

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States

RECRUITING

Medical University of South Carolina

Charleston, South Carolina, United States

NOT YET RECRUITING

Dell Children's Medical Center

Austin, Texas, 78723, United States

RECRUITING

Medical City Children's Hospital

Dallas, Texas, 75230, United States

RECRUITING

University of Texas Southwestern

Dallas, Texas, 75390, United States

RECRUITING

The Children's Hospital of San Antonio

San Antonio, Texas, 78207, United States

RECRUITING

Children's Hospital of Richmond at VCU

Richmond, Virginia, 23219, United States

RECRUITING

Seattle Children's Hospital

Seattle, Washington, 98105, United States

RECRUITING

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

The Children's Hospital at Westmead

Westmead, New South Wales, 2145, Australia

RECRUITING

Perth Children's Hospital

Nedlands, 6009, Australia

RECRUITING

Queensland Children's Hospital

South Brisbane, 4101, Australia

RECRUITING

Sabara Hospital Infantil

São Paulo, 01227-200, Brazil

RECRUITING

Stollery Children's Hospital

Edmonton, Alberta, T6G 2B7, Canada

RECRUITING

BC Children's

Vancouver, British Columbia, V6H 3N1, Canada

RECRUITING

Alberta Children's

Calgary, AB T3B, Canada

RECRUITING

Instituto Roosevelt

Bogotá, Colombia

RECRUITING

IRCCS Ospedale Pediatrico Bambino Gesù

Roma, 486686, Italy

RECRUITING

Aichi Children's Health and Medical Center

Aichi, 474-8710, Japan

RECRUITING

Kobe Children's Hospital (Hyogo Prefectural)

Kobe, 650-0047, Japan

RECRUITING

Tokyo Metropolitan Children's Medical Center

Tokyo, 183-8561, Japan

RECRUITING

Erasmus MC - Sophia Children's

Rotterdam, 3015, Netherlands

RECRUITING

Starship Children's Hospital

Auckland, 1023, New Zealand

RECRUITING

National University Hospital

Singapore, 119074, Singapore

RECRUITING

KK Women's & Children's Hospital

Singapore, 229899, Singapore

RECRUITING

Seoul National University Bundang Hospital

Seongnam, 13620, South Korea

RECRUITING

Gregorio Marañón General University Hospital

Madrid, 46 28007, Spain

RECRUITING

National Taiwan University Hospital

Taipei, 100229, Taiwan

RECRUITING

King Chulalongkorn University

Bangkok, 10330, Thailand

RECRUITING

Great Ormond Street Hospital

London, WC1N 3JH, United Kingdom

RECRUITING

Related Publications (9)

  • Niles DE, Duval-Arnould J, Skellett S, Knight L, Su F, Raymond TT, Sweberg T, Sen AI, Atkins DL, Friess SH, de Caen AR, Kurosawa H, Sutton RM, Wolfe H, Berg RA, Silver A, Hunt EA, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Characterization of Pediatric In-Hospital Cardiopulmonary Resuscitation Quality Metrics Across an International Resuscitation Collaborative. Pediatr Crit Care Med. 2018 May;19(5):421-432. doi: 10.1097/PCC.0000000000001520.

    PMID: 29533355BACKGROUND
  • Sweberg T, Sen AI, Mullan PC, Cheng A, Knight L, Del Castillo J, Ikeyama T, Seshadri R, Hazinski MF, Raymond T, Niles DE, Nadkarni V, Wolfe H; pediatric resuscitation quality (pediRES-Q) collaborative investigators. Description of hot debriefings after in-hospital cardiac arrests in an international pediatric quality improvement collaborative. Resuscitation. 2018 Jul;128:181-187. doi: 10.1016/j.resuscitation.2018.05.015. Epub 2018 May 26.

    PMID: 29768181BACKGROUND
  • Pfeiffer S, Lauridsen KG, Wenger J, Hunt EA, Haskell S, Atkins DL, Duval-Arnould JM, Knight LJ, Cheng A, Gilfoyle E, Su F, Balikai S, Skellett S, Hui MY, Niles DE, Roberts JS, Nadkarni VM, Tegtmeyer K, Dewan M; Pediatric Resuscitation Quality Collaborative Investigators. Code Team Structure and Training in the Pediatric Resuscitation Quality International Collaborative. Pediatr Emerg Care. 2021 Aug 1;37(8):e431-e435. doi: 10.1097/PEC.0000000000001748.

    PMID: 31045955BACKGROUND
  • Esangbedo I, Yu P, Raymond T, Niles DE, Hanna R, Zhang X, Wolfe H, Griffis H, Nadkarni V; Pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Pediatric in-hospital CPR quality at night and on weekends. Resuscitation. 2020 Jan 1;146:56-63. doi: 10.1016/j.resuscitation.2019.10.039. Epub 2019 Nov 14.

    PMID: 31734222BACKGROUND
  • Wolfe HA, Wenger J, Sutton R, Seshadri R, Niles DE, Nadkarni V, Duval-Arnould J, Sen AI, Cheng A. Cold Debriefings after In-hospital Cardiac Arrest in an International Pediatric Resuscitation Quality Improvement Collaborative. Pediatr Qual Saf. 2020 Jul 8;5(4):e319. doi: 10.1097/pq9.0000000000000319. eCollection 2020 Jul-Aug.

    PMID: 32766493BACKGROUND
  • Raymond TT, Esangbedo ID, Rajapreyar P, Je S, Zhang X, Griffis HM, Wakeham MK, Petersen TL, Kirschen MP, Topjian AA, Lasa JJ, Francoeur CI, Nadkarni VM; pediatric Resuscitation Quality (pediRES-Q) Collaborative Investigators. Cerebral Oximetry During Pediatric In-Hospital Cardiac Arrest: A Multicenter Study of Survival and Neurologic Outcome. Crit Care Med. 2024 May 1;52(5):775-785. doi: 10.1097/CCM.0000000000006186. Epub 2024 Jan 5.

  • Ong GY, Chen ZJ, Niles DE, Srinivasan V, Sen AI, Skellett S, Ikeyama T, Del Castillo J, Berg RA, Nadkarni VM. Poor Concordance of One-Third Anterior-Posterior Chest Diameter Measurements With Absolute Age-Specific Chest Compression Depth Targets in Pediatric Cardiac Arrest Patients. J Am Heart Assoc. 2023 Jul 18;12(14):e028418. doi: 10.1161/JAHA.122.028418. Epub 2023 Jul 8.

  • Gray JM, Raymond TT, Atkins DL, Tegtmeyer K, Niles DE, Nadkarni VM, Pandit SV, Dewan M; pediRES-Q Investigators. Inappropriate Shock Delivery Is Common During Pediatric In-Hospital Cardiac Arrest. Pediatr Crit Care Med. 2023 Aug 1;24(8):e390-e396. doi: 10.1097/PCC.0000000000003241. Epub 2023 Apr 28.

  • Raymond TT, Pandit SV, Griffis H, Zhang X, Hanna R, Niles DE, Silver A, Lasa JJ, Haskell SE, Atkins DL, Nadkarni VM; Pediatric Resuscitation Quality Collaborative (pediRES-Q) Investigators. Effect of Amplitude Spectral Area on Termination of Fibrillation and Outcomes in Pediatric Cardiac Arrest. J Am Heart Assoc. 2021 Jun 15;10(12):e020353. doi: 10.1161/JAHA.120.020353. Epub 2021 Jun 5.

Related Links

MeSH Terms

Conditions

Heart Arrest

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Study Officials

  • Vinay Nadkarni, MD, MS

    Children's Hospital of Philadelphia

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Vinay Nadkarni, MD, MS

CONTACT

Kathryn Graham

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 28, 2016

First Posted

March 15, 2016

Study Start

May 2, 2016

Primary Completion (Estimated)

January 1, 2030

Study Completion (Estimated)

January 1, 2030

Last Updated

October 2, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations