Impact of Exercise on the Metabolic Consequences of Overeating

NCT02701738 | Completed

• 1 other identifier: HUM00102772
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The primary purpose of this study is to examine the effects of 1-week of overeating on important clinical metabolic health outcomes (e.g., glucose tolerance, blood lipid profile, and blood pressure) and factors regulating the structure and metabolic function of fat tissue. This study will determine how regular exercise during this overeating period impacts these responses.

Conditions

Healthy

Outcome Measures

Primary Outcomes (1)

• Oral Glucose Tolerance

  An index of insulin sensitivity will be measured using the plasma insulin and glucose concentrations during the 3h OGTT

  up to 1 week

Secondary Outcomes (3)

• Resting Metabolic Rate

  baseline and 1 week

• Total Cholesterol

  baseline and 1 week

• PPARg mRNA expression

  baseline and 1 week

Study Arms (1)

Overeating Protocol

EXPERIMENTAL

Subjects will ingest 30% more calories per day than their calculated daily energy requirements (\~750kcals extra energy intake each day). All subjects will be instructed (and will be guided) to consume a diet containing approximately 50% carbohydrate, 35% fat, and 15% protein.

Dietary Supplement: Overeating Protocol

Interventions

Overeating Protocol DIETARY_SUPPLEMENT

Subjects will ingest 30% more calories per day than their calculated daily energy requirements (\~750kcals extra energy intake each day). All subjects will be instructed (and will be guided) to consume a diet containing approximately 50% carbohydrate, 35% fat, and 15% protein.

Overeating Protocol

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age: 18-40
• Body Mass Index: 20-30 kg/m2
• Exercise group: (≥5 days/wk of aerobic exercise; 30-60min/session at moderate and vigorous intensities)
• No Exercise group: no regularly planned exercise/physical activity
• Women must have regularly occurring menses and must be premenopausal

You may not qualify if:

• Pregnant or lactating
• Blood pressure \> 140/90 mm Hg
• Evidence/history of cardiovascular or metabolic disease
• Medications known to affect lipid or glucose metabolism
• Tobacco or electronic cigarette user

Sponsors & Collaborators

• University of Michigan: lead

Study Sites (1)

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location

Related Publications (1)

• Ludzki AC, Krueger EM, Gillen JB, Taylor NM, Middlebrook DO, Baldwin TC, Karabetsos KC, Schleh MW, Horowitz JF. One week of overeating upregulates angiogenic and lipolytic gene expression in human subcutaneous adipose tissue from exercise trained and untrained adults. Appl Physiol Nutr Metab. 2022 Oct 1;47(10):992-1004. doi: 10.1139/apnm-2022-0078. Epub 2022 Jul 11.

  PMID: 35816737 DERIVED

Study Officials

• Jeffrey F Horowitz

  University of Michigan

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor, Movement Science and Director, Substrate Metabolism Laboratory

Study Record Dates

• First Submitted: January 21, 2016
• First Posted: March 8, 2016
• Study Start: January 12, 2016
• Primary Completion: December 8, 2017
• Study Completion: December 8, 2017
• Last Updated: March 21, 2022

Record last verified: 2022-03

Locations

US (1)