Magnetic Resonance Imaging (MRI) Fat Quantification of the Liver
MRI Fat Quantification of the Liver, Subcutaneous and Visceral Fatty Tissue in Patients Before and After Bariatric Surgery
1 other identifier
interventional
15
1 country
1
Brief Summary
Fatty liver in the obese is a common finding; some cases develop steato-hepatosis which in the long-term can lead to liver cirrhosis. The effect of bariatric surgery on fat distribution in the liver has so far been studied with liver biopsies and single voxel MR techniques. With this trial investigators present a new, whole organ MR-quantification of liver fat and describe changes after bariatric surgery in visceral and subcutaneous fat.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2013
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2013
CompletedFirst Submitted
Initial submission to the registry
February 1, 2016
CompletedFirst Posted
Study publicly available on registry
February 15, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2017
CompletedJuly 27, 2017
July 1, 2017
4.3 years
February 1, 2016
July 25, 2017
Conditions
Outcome Measures
Primary Outcomes (1)
Liver fat quantification
change in fat quantification; measurement of fat rate in the organ
within 3, 6 and 12 months of surgery
Secondary Outcomes (2)
Visceral fat quantification
within 3, 6 and 12 months of surgery
Subcutaneous fat quantification
within 3, 6 and 12 months of surgery
Study Arms (2)
Laparoscopic gastric bypass
ACTIVE COMPARATORMR Abdomen in morbidly obese patients receiving gastric bypass
Laparoscopic sleeve gastrectomy
ACTIVE COMPARATORMR Abdomen morbidly obese patients receiving sleeve gastrectomy
Interventions
Eligibility Criteria
You may qualify if:
- morbidly obese patients with BMI over 35, scheduled for bariatric surgery (either sleeve gastrectomy or gastric bypass)
You may not qualify if:
- Smoking
- substance abuse
- Diabetes
- history of gastrointestinal disorders
- pace-maker
- claustrophobia
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University Hospital
Basel, CH-4031, Switzerland
Related Publications (1)
Meyer-Gerspach AC, Peterli R, Moor M, Madorin P, Schotzau A, Nabers D, Borgwardt S, Beglinger C, Bieri O, Wolnerhanssen BK. Quantification of Liver, Subcutaneous, and Visceral Adipose Tissues by MRI Before and After Bariatric Surgery. Obes Surg. 2019 Sep;29(9):2795-2805. doi: 10.1007/s11695-019-03897-2.
PMID: 31089967DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Christoph Beglinger, MD
University Hospital, Basel, Switzerland
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
February 1, 2016
First Posted
February 15, 2016
Study Start
March 1, 2013
Primary Completion
July 1, 2017
Study Completion
July 1, 2017
Last Updated
July 27, 2017
Record last verified: 2017-07
Data Sharing
- IPD Sharing
- Will not share