Healthy Aging Longitudinal Study in Taiwan

NCT02677831 | Unknown

• 1 other identifier: EC0970608
• Study Type: observational
• Target: 5,664
• Locations: 0 countries
• Sites: N/A

Brief Summary

The general aim of this study is to establish a longitudinal cohort of older persons in order to examine the physiological, environmental and genetic risk factors for physical disability, frailty, cardiovascular disease, and neuropsychiatric disorders in older persons and to examine the benefit of healthy lifestyles. The findings from this study will provide information necessary for the development of effective health policy for aging people.

Conditions

Cardiovascular Diseases; Metabolic Diseases

Keywords

Physical functioning; Neuropsychiatric Disorders; Frailty

Outcome Measures

Primary Outcomes (9)

• Independence in daily life assessed by Barthel Index

  The Barthel Index will be adapted to assess the ability to cope with 10 items of daily activities. These tasks include feeding, moving from wheelchair to bed, personal toilet, getting on and off the toilet, bathing, walking on a level surface, ascending and descending stairs, dressing, controlling bowel, and controlling bladder. The total score ranges from 0 to 100, with 100 representing full independence in doing daily activities.

  20 years

• Independence in daily life assessed by Lawton-Brody Instrumental Activities of Daily Living (IADL) scale

  IADL scale is used to measure a participant's ability to adapt to the environment and consists of 8 tasks: shopping, housekeeping, money management, food preparation, laundry, transportation, use of the telephone, and medications. The total score is from 0 (worst) to 8 (best).

  20 years

• Declined rate of physical performance assessed by peak flow test

  The peak flow test, is a measure of lung function, the participant is asked to take a deep breath and blow as fast and hard as possible into the meter at a standing or sitting position. The maximum value in liter per minute of three to five trials of forced expiration is chosen as the peak flow.

  20 years

• Declined rate of physical performance assessed by grip strength

  The participant is instructed to use the dominant hand to grip the dynamometer as hard as possible three times. The maximum value in kilograms of three trials is recorded as maximal grip strength.

  20 years

• Declined rate of physical performance assessed by Summary Physical Performance Battery (SPPB)

  The SPPB, is a measure of lower extremity function and represents the participant's performance on three performance-based tests: 4-meter timed walk, five chair stands, and balance in three different standing positions side by side, semi-tandem, and full tandem. Participants will receive a score of 0 to 4 for each test. The summary performance score is the sum of scores calculated across the three tests, with 0 representing the worst and 12 the best.

  20 years

• Cardiovascular disease incidence by linking the National Health Insurance Research Database in Taiwan

  20 years

• Dementia incidence by linking the National Health Insurance Research Database in Taiwan

  20 years

• Overall cancer incidence by linking the National Health Insurance Research Database in Taiwan

  20 years

• All cause mortality

  20 years

Eligibility Criteria

• Age: 55 Years - 104 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Investigators plan to conduct a longitudinal study on a cohort of 5,000+ men and women ages 55 years or older to address issues related to healthy aging. The study population consists community-based middle to old aged men and women in the catchment area of 7 hospitals (2 in the north, 2 in the middle, 2 in the south and 1 in the east, about half urban half rural). In this proposed study, investigators will recruit the subjects in the catchment area of the above 7 hospitals and expand data collection to include more interviewer-administered data, physical examinations and blood and urine specimens.

You may qualify if:

• ages 55 years or older

You may not qualify if:

• high transmitted disease (such as scabies, open pulmonary tuberculosis)
• severe illness (such as cancer under treatment)
• diagnosed dementia
• severe illness and being bed-ridden, unable to move
• severe mental disorder, cannot be communicated with（MMSE\<16）
• dumbness or hearing impairment, unable to complete the interview
• unsighted completely, unable to complete the interview and test
• \< 55 years of age
• Other conditions, such as living in a long-term care facility or being hospitalized

Sponsors & Collaborators

• National Health Research Institutes, Taiwan: lead
• Shin Kong Wu Ho-Su Memorial Hospital: collaborator
• Hope Doctors Hospital: collaborator
• Changhua Christian Hospital: collaborator
• Puzi Hospital: collaborator
• Yuan's General Hospital: collaborator
• Mennonite Christian Hospital: collaborator
• CHC Hospital Group: collaborator
• Northwestern University: collaborator
• University of California, San Francisco: collaborator

Related Publications (4)

• Wu IC, Chang HY, Hsu CC, Chiu YF, Yu SH, Tsai YF, Shen SC, Kuo KN, Chen CY, Liu K, Lee MM, Hsiung CA. Association between dietary fiber intake and physical performance in older adults: a nationwide study in Taiwan. PLoS One. 2013 Nov 11;8(11):e80209. doi: 10.1371/journal.pone.0080209. eCollection 2013.

  PMID: 24244650 RESULT

• Wu IC, Lin CC, Hsiung CA, Wang CY, Wu CH, Chan DC, Li TC, Lin WY, Huang KC, Chen CY, Hsu CC; Sarcopenia and Translational Aging Research in Taiwan Team. Epidemiology of sarcopenia among community-dwelling older adults in Taiwan: a pooled analysis for a broader adoption of sarcopenia assessments. Geriatr Gerontol Int. 2014 Feb;14 Suppl 1:52-60. doi: 10.1111/ggi.12193.

  PMID: 24450561 RESULT

• Tseng HY, Lockenhoff C, Lee CY, Yu SH, Wu IC, Chang HY, Chiu YF, Hsiung CA. The paradox of aging and health-related quality of life in Asian Chinese: results from the Healthy Aging Longitudinal Study in Taiwan. BMC Geriatr. 2020 Mar 5;20(1):91. doi: 10.1186/s12877-020-1446-y.

  PMID: 32138691 DERIVED

• Chuang SC, Chen HL, Tseng WT, Wu IC, Hsu CC, Chang HY, Chen YI, Lee MM, Liu K, Hsiung CA. Circulating 25-hydroxyvitamin D and physical performance in older adults: a nationwide study in Taiwan. Am J Clin Nutr. 2016 Nov;104(5):1334-1344. doi: 10.3945/ajcn.115.122804. Epub 2016 Oct 12.

  PMID: 27733394 DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

whole blood, serum, urine.

MeSH Terms

Conditions

Cardiovascular Diseases; Metabolic Diseases; Frailty

Condition Hierarchy (Ancestors)

Nutritional and Metabolic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Distinguished Investigator/Director

Study Record Dates

• First Submitted: January 24, 2016
• First Posted: February 9, 2016
• Study Start: July 1, 2008
• Primary Completion: March 1, 2013
• Study Completion: December 1, 2020
• Last Updated: March 31, 2017

Record last verified: 2017-03

Data Sharing

• IPD Sharing: Will not share