NCT02671812

Brief Summary

The general aim of this project is to investigate the long-term treatment outcome after implant therapy. The patients' satisfaction with implant treatment will be studied and correlated to biological and technical problems. The survival rates of implants at patient level and the degree of bone loss of remaining teeth and implants will be calculated. The levels of cytokines and bone loss markers in peri-implantitis sites and periodontal defects and at healthy sites will be analyzed in order to study the correlation between cytokine and bone loss marker levels, and clinical conditions. Independent variables which could be regarded as significant risk factors or risk predictors on the incidence of peri-implantitis are aimed to be identified

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
163

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Nov 2014

Typical duration for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 27, 2014

Completed
1.2 years until next milestone

First Submitted

Initial submission to the registry

January 30, 2016

Completed
3 days until next milestone

First Posted

Study publicly available on registry

February 2, 2016

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

August 1, 2018

Completed
Last Updated

January 14, 2026

Status Verified

February 1, 2019

Enrollment Period

3.7 years

First QC Date

January 30, 2016

Last Update Submit

January 13, 2026

Conditions

PROMsPeri-implantitisMucositisPeriodontitis

Keywords

dental implantpatient satisfactiontreatment outcomecytokine profilerisk factorrisk predictor

Outcome Measures

Primary Outcomes (1)

  • Patients satisfaction after dental implant treatment

    Questionnaire and clinical examination

    10 years after implant treatment

Secondary Outcomes (2)

  • Complications prevalence

    10 years after implant treatment

  • Profile of inflamatory markers

    10 years after implant treatment

Eligibility Criteria

Age20 Years - 81 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

All patients treated with dental implants at the Specialist Clinic Skanstull, Stockholm, Sweden, between 1999-2005

You may qualify if:

  • \- Treated at the Specialist Clinic Skanstull, Stockholm, Sweden with dental implants between the years of 1999-2005

You may not qualify if:

  • \- Deceased before or during the study period

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Related Publications (7)

  • Derks J, Tomasi C. Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol. 2015 Apr;42 Suppl 16:S158-71. doi: 10.1111/jcpe.12334.

    PMID: 25495683RESULT

  • Pjetursson BE, Karoussis I, Burgin W, Bragger U, Lang NP. Patients' satisfaction following implant therapy. A 10-year prospective cohort study. Clin Oral Implants Res. 2005 Apr;16(2):185-93. doi: 10.1111/j.1600-0501.2004.01094.x.

    PMID: 15777328RESULT

  • Derks J, Hakansson J, Wennstrom JL, Klinge B, Berglundh T. Patient-reported outcomes of dental implant therapy in a large randomly selected sample. Clin Oral Implants Res. 2015 May;26(5):586-91. doi: 10.1111/clr.12464. Epub 2014 Aug 14.

    PMID: 25123298RESULT

  • Heitz-Mayfield LJ. Peri-implant diseases: diagnosis and risk indicators. J Clin Periodontol. 2008 Sep;35(8 Suppl):292-304. doi: 10.1111/j.1600-051X.2008.01275.x.

    PMID: 18724857RESULT

  • Roccuzzo M, Bonino F, Aglietta M, Dalmasso P. Ten-year results of a three arms prospective cohort study on implants in periodontally compromised patients. Part 2: clinical results. Clin Oral Implants Res. 2012 Apr;23(4):389-95. doi: 10.1111/j.1600-0501.2011.02309.x. Epub 2011 Sep 28.

    PMID: 22092445RESULT

  • Andreiotelli M, Koutayas SO, Madianos PN, Strub JR. Relationship between interleukin-1 genotype and peri-implantitis: a literature review. Quintessence Int. 2008 Apr;39(4):289-98.

    PMID: 19081897RESULT

  • Sharma CG, Pradeep AR. Plasma and crevicular fluid osteopontin levels in periodontal health and disease. J Periodontal Res. 2007 Oct;42(5):450-5. doi: 10.1111/j.1600-0765.2007.00968.x.

    PMID: 17760823RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Saliva and gingival fluid

MeSH Terms

Conditions

Peri-ImplantitisMucositisPeriodontitisPatient Satisfaction

Condition Hierarchy (Ancestors)

Periodontal DiseasesMouth DiseasesStomatognathic DiseasesGastroenteritisGastrointestinal DiseasesDigestive System DiseasesTreatment Adherence and ComplianceHealth BehaviorBehavior

Study Officials

  • Margaret Sällberg Chen, Assc. Prof

    Karolinska Institutet Odontologen

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
DDS PhD-student

Study Record Dates

First Submitted

January 30, 2016

First Posted

February 2, 2016

Study Start

November 27, 2014

Primary Completion

August 1, 2018

Study Completion

August 1, 2018

Last Updated

January 14, 2026

Record last verified: 2019-02

Data Sharing

IPD Sharing
Will not share