Peri-implantitis in HIV-positive Patients

NCT04829968 | Completed DMC

• 1 other identifier: PERIHIV2
• Study Type: observational
• Target: 58
• Locations: 1 country
• Sites: 1

Brief Summary

Objectives: This study aimed to assess the prevalence of peri-implantitis in human im-munodeficiency virus (HIV) -positive patients and the presence of a possible correlation between the immunological profile and serological values, of peri-implantitis, and of pos-sible differences between all-on-4 and single crown/bridge prostheses. Subjects and methods: This retrospective study included 58 adult HIV-positive patients (222 implants) with either all-in-4 prostheses or single crowns/bridges on at least one dental implant loaded for more than a year who were followed for at least one year. Data pertaining to the probing pocket depth (PPD), bleeding on probing, and immunological and systemic profile were collected. Results: Patients with single crown/bridge implant rehabilitation showed higher preva-lence of peri-implantitis (34%) than patients with all-on-4 rehabilitation (0%) (p=0.012). Patients with all-on-4 rehabilitation were significantly older than those with single crowns/bridges (p=0.004). Patients with peri-implantitis had implants for a significantly longer duration than those without (p=0.001), implying that the probability of peri-implantitis increases as the age of implant increases. Conclusions: The prevalence of peri-implantitis was 26% in HIV-positive patients and 8% in dental implants. No correlation was found between patients' immunological and se-rological factors and peri-implantitis. The most important risk factor for peri-implantitis and mucositis was implant age.

Conditions

Peri-Implantitis

Keywords

peri-implantitis; mucositis; HIV-positive patients; All-on-4

Outcome Measures

Primary Outcomes (1)

• Peri-implantitis prevalence

  This study aimed to assess the prevalence of peri-implantitis in HIV-positive patients and to evaluate the presence of a possible correlation between the immunological profile and serological values of the same HIV-positive patients, of peri-implantitis, and of possible differences between all-on-4 and single crown/bridge prostheses in terms of peri-implant disease and the variables analyzed.

  3 years

Interventions

gingival conditions control OTHER

Peri-implant mucositis: It was diagnosed on the basis of the following criteria: 1. Visual inspection demonstrating the following signs of inflammation in the peri-implant region: red as opposed to pink colour, swollen tissues as opposed to no swelling, and soft as opposed to firm tissue consistency. 2. Presence of profuse (line or drop) bleeding and/or suppuration on probing. 3. An increase in probing pocket depths (PPDs) compared to baseline. • Peri-implantitis: It was diagnosed on the basis of the following criteria: 1\. Visual inflammatory changes in the peri-implant soft tissues combined with bleeding on probing and/or suppuration. 2\. Increasing PPDs as compared to measurements recorded at the time of placement of supra-structures.

Eligibility Criteria

• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

58 HIV-positive patients

Sponsors & Collaborators

• Università Vita-Salute San Raffaele: lead

Study Sites (1)

Luca Casula

Monza, Monza E Della Brianza, 20900, Italy

Location

Related Publications (1)

• Casula L, Poli A, Clemente T, Artuso G, Cappare P, Gherlone EF. Prevalence of peri-implantitis in a sample of HIV-positive patients. Clin Exp Dent Res. 2021 Dec;7(6):1002-1013. doi: 10.1002/cre2.469. Epub 2021 Jul 20.

  PMID: 34288560 DERIVED

MeSH Terms

Conditions

Peri-Implantitis; Mucositis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Target Duration: 3 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, MSc resident in Oral Surgery

Study Record Dates

• First Submitted: March 30, 2021
• First Posted: April 2, 2021
• Study Start: January 1, 2015
• Primary Completion: November 1, 2019
• Study Completion: November 30, 2019
• Last Updated: April 2, 2021

Record last verified: 2021-03

Data Sharing

• IPD Sharing: Will not share

Locations

IT (1)