NCT02663232

Brief Summary

This is a national, multicenter, cross-sectional epidemiological study in adult Spanish participants diagnosed with advanced or metastatic melanoma.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
264

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jun 2013

Geographic Reach
1 country

33 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2013

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 1, 2014

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2014

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

November 20, 2015

Completed
2 months until next milestone

First Posted

Study publicly available on registry

January 26, 2016

Completed
2 months until next milestone

Results Posted

Study results publicly available

April 5, 2016

Completed
Last Updated

July 3, 2023

Status Verified

June 1, 2023

Enrollment Period

1.3 years

First QC Date

November 20, 2015

Results QC Date

March 3, 2016

Last Update Submit

June 29, 2023

Conditions

Keywords

V600 BRAF mutationMetastatic melanoma

Outcome Measures

Primary Outcomes (1)

  • Percentage of Participants With V600 BRAF Mutation Status

    Presence or absence of mutations in the V600 BRAF oncogene was determined in all eligible participants. Data collection and management of BRAF mutation testing was carried out using the Biomarker point® online platform. The platform was used as an electronic case report form (e-CRF) for collecting information in electronic format via a website. Percentage of participants with BRAF mutation status (mutated BRAF, wild type, not available) were reported.

    Day 1

Secondary Outcomes (17)

  • Percentage of Participants Categorized by Melanoma Stage

    Day 1

  • Percentage of Participants With Family History of Melanoma

    Day 1

  • Percentage of Participants With Sun Exposure

    Day 1

  • Percentage of Participants Categorized by Primary Tumor Location

    Day 1

  • Percentage of Participants Categorized By LDH Level

    Day 1

  • +12 more secondary outcomes

Study Arms (1)

Metastatic melanoma

Participants with metastatic melanoma who attend their physicians during the 18-month recruitment period and have valid biological samples available for BRAF mutation testing will be included in the study. There will be no intervention in this study.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Participants diagnosed with metastatic melanoma who have valid samples for BRAF mutation testing and give their informed consent will be included in this trial.

You may qualify if:

  • Valid tumor samples from participants diagnosed with Stage IIIc or IV melanoma
  • Written informed consent granted

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (33)

Unknown Facility

Palma de Mallorca, Balearic Islands, 07198, Spain

Location

Unknown Facility

Jerez de la Frontera, Cadiz, 11407, Spain

Location

Unknown Facility

Santander, Cantabria, 39008, Spain

Location

Unknown Facility

Castellon, Castellon, 12002, Spain

Location

Unknown Facility

Donostia / San Sebastian, Guipuzcoa, 20080, Spain

Location

Unknown Facility

A Coruña, LA Coruña, 15006, Spain

Location

Unknown Facility

Cartagena (Murcia), Murcia, 30202, Spain

Location

Unknown Facility

Pamplona, Navarre, 31008, Spain

Location

Unknown Facility

Oviedo, Principality of Asturias, 33011, Spain

Location

Unknown Facility

Santa Cruz de Tenerife, Tenerife, 38010, Spain

Location

Unknown Facility

Bilbao, Vizcaya, 48013, Spain

Location

Unknown Facility

Barcelona, 08003, Spain

Location

Unknown Facility

Barcelona, 08035, Spain

Location

Unknown Facility

Barcelona, 08036, Spain

Location

Unknown Facility

Barcelona, 08916, Spain

Location

Unknown Facility

Burgos, 09006, Spain

Location

Unknown Facility

Cáceres, 10003, Spain

Location

Unknown Facility

Girona, 17007, Spain

Location

Unknown Facility

Granada, 18014, Spain

Location

Unknown Facility

Lleida, 25198, Spain

Location

Unknown Facility

Madrid, 28002, Spain

Location

Unknown Facility

Madrid, 28007, Spain

Location

Unknown Facility

Madrid, 28034, Spain

Location

Unknown Facility

Madrid, 28041, Spain

Location

Unknown Facility

Madrid, 28046, Spain

Location

Unknown Facility

Málaga, 29010, Spain

Location

Unknown Facility

Murcia, 30120, Spain

Location

Unknown Facility

Salamanca, 37007, Spain

Location

Unknown Facility

Seville, 41009, Spain

Location

Unknown Facility

Toledo, 45004, Spain

Location

Unknown Facility

Valencia, 41014, Spain

Location

Unknown Facility

Valencia, 46017, Spain

Location

Unknown Facility

Zaragoza, 50009, Spain

Location

MeSH Terms

Conditions

NeoplasmsMelanoma

Condition Hierarchy (Ancestors)

Neuroendocrine TumorsNeuroectodermal TumorsNeoplasms, Germ Cell and EmbryonalNeoplasms by Histologic TypeNeoplasms, Nerve TissueNevi and MelanomasSkin NeoplasmsNeoplasms by SiteSkin DiseasesSkin and Connective Tissue Diseases

Results Point of Contact

Title
Medical Communications
Organization
Hoffmann-LaRoche

Study Officials

  • Clinical Trials

    Hoffmann-La Roche

    STUDY DIRECTOR

Publication Agreements

PI is Sponsor Employee
No
Restriction Type
OTHER
Restrictive Agreement
Yes

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 20, 2015

First Posted

January 26, 2016

Study Start

June 1, 2013

Primary Completion

October 1, 2014

Study Completion

October 1, 2014

Last Updated

July 3, 2023

Results First Posted

April 5, 2016

Record last verified: 2023-06

Locations