NCT02650531

Brief Summary

A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
816

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started May 2015

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

May 1, 2015

Completed
7 months until next milestone

First Submitted

Initial submission to the registry

December 10, 2015

Completed
29 days until next milestone

First Posted

Study publicly available on registry

January 8, 2016

Completed
2.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

October 8, 2018

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

October 8, 2018

Completed
Last Updated

February 23, 2022

Status Verified

February 1, 2022

Enrollment Period

3.4 years

First QC Date

December 10, 2015

Last Update Submit

February 6, 2022

Conditions

DementiaMild Cognitive ImpairmentStroke

Keywords

Follow up studiesRisk factors

Outcome Measures

Primary Outcomes (1)

  • Score on the Montreal cognitive assessment (MOCA)

    Performance based test

    18 months

Secondary Outcomes (8)

  • Score on the Montreal cognitive assessment (MOCA)

    3 months

  • Time spent in upright position

    3 months

  • Time spent in upright position

    18 months

  • Brain Imaging

    18 months

  • Score on Short Physical Performance Battery (sppb)

    3 months

  • +3 more secondary outcomes

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with acute stroke

You may qualify if:

  • Stroke diagnosis according to the WHO criteria

You may not qualify if:

  • Not scandinavian speaking

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Norwegian University of Science and Technology

Trondheim, 7006, Norway

Location

Related Publications (19)

  • Thingstad P, Askim T, Beyer MK, Brathen G, Ellekjaer H, Ihle-Hansen H, Knapskog AB, Lydersen S, Munthe-Kaas R, Naess H, Pendlebury ST, Seljeseth YM, Saltvedt I. The Norwegian Cognitive impairment after stroke study (Nor-COAST): study protocol of a multicentre, prospective cohort study. BMC Neurol. 2018 Nov 26;18(1):193. doi: 10.1186/s12883-018-1198-x.

    PMID: 30477436BACKGROUND

  • Waehler IS, Saltvedt I, Lydersen S, Fure B, Askim T, Einstad MS, Thingstad P. Association between in-hospital frailty and health-related quality of life after stroke: the Nor-COAST study. BMC Neurol. 2021 Mar 4;21(1):100. doi: 10.1186/s12883-021-02128-5.

    PMID: 33663430RESULT

  • Sandvig HV, Saltvedt I, Edwin TH, Aam S, Alme KN, Eldholm RS, Lydersen S, Mollnes TE, Munthe-Kaas R, Ueland PM, Ulvik A, Wethal T, Knapskog AB. Associations between systemic inflammation and cognitive trajectories post-stroke. Sci Rep. 2025 Nov 28;15(1):42791. doi: 10.1038/s41598-025-27119-1.

    PMID: 41315409DERIVED

  • Sandvig HV, Aam S, Alme KN, Lydersen S, Magne Ueland P, Ulvik A, Wethal T, Saltvedt I, Knapskog AB. Neopterin, kynurenine metabolites, and indexes related to vitamin B6 are associated with post-stroke cognitive impairment: The Nor-COAST study. Brain Behav Immun. 2024 May;118:167-177. doi: 10.1016/j.bbi.2024.02.030. Epub 2024 Feb 28.

    PMID: 38428649DERIVED

  • Luzum G, Thrane G, Aam S, Eldholm RS, Grambaite R, Munthe-Kaas R, Thingstad P, Saltvedt I, Askim T. A Machine Learning Approach to Predict Post-stroke Fatigue. The Nor-COAST study. Arch Phys Med Rehabil. 2024 May;105(5):921-929. doi: 10.1016/j.apmr.2023.12.005. Epub 2024 Jan 17.

    PMID: 38242298DERIVED

  • Navickaite E, Saltvedt I, Lydersen S, Munthe-Kaas R, Ihle-Hansen H, Grambaite R, Aam S. Diagnostic accuracy of the Clock Drawing Test in screening for early post-stroke neurocognitive disorder: the Nor-COAST study. BMC Neurol. 2024 Jan 9;24(1):22. doi: 10.1186/s12883-023-03523-w.

    PMID: 38195396DERIVED

  • Luzum G, Gunnes M, Lydersen S, Saltvedt I, Tan X, Thingstad P, Thrane G, Askim T. Physical Activity Behavior and Its Association With Global Cognitive Function Three Months After Stroke: The Nor-COAST Studydagger. Phys Ther. 2023 Dec 6;103(12):pzad092. doi: 10.1093/ptj/pzad092.

    PMID: 37440440DERIVED

  • Sandvig HV, Aam S, Alme KN, Askim T, Beyer MK, Ellekjaer H, Ihle-Hansen H, Lydersen S, Mollnes TE, Munthe-Kaas R, Naess H, Saltvedt I, Seljeseth YM, Thingstad P, Wethal T, Knapskog AB. Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study. Stroke. 2023 May;54(5):1303-1311. doi: 10.1161/STROKEAHA.122.041965. Epub 2023 Apr 7.

    PMID: 37026459DERIVED

  • Gynnild MN, Hageman SHJ, Spigset O, Lydersen S, Saltvedt I, Dorresteijn JAN, Visseren FLJ, Ellekjaer H. Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment. Open Heart. 2022 Apr;9(1):e001972. doi: 10.1136/openhrt-2022-001972.

    PMID: 35459718DERIVED

  • Munthe-Kaas R, Aam S, Saltvedt I, Wyller TB, Pendlebury ST, Lydersen S, Hagberg G, Schellhorn T, Rostoft S, Ihle-Hansen H. Is Frailty Index a better predictor than pre-stroke modified Rankin Scale for neurocognitive outcomes 3-months post-stroke? BMC Geriatr. 2022 Feb 19;22(1):139. doi: 10.1186/s12877-022-02840-y.

    PMID: 35183106DERIVED

  • Einstad MS, Thingstad P, Lydersen S, Gunnes M, Saltvedt I, Askim T. Physical Performance and Cognition as Predictors of Instrumental Activities of Daily Living After Stroke: A Prospective Multicenter Cohort Study. Arch Phys Med Rehabil. 2022 Jul;103(7):1320-1326. doi: 10.1016/j.apmr.2022.01.153. Epub 2022 Feb 16.

    PMID: 35181266DERIVED

  • Alme KN, Ulvik A, Askim T, Assmus J, Mollnes TE, Naik M, Naess H, Saltvedt I, Ueland PM, Knapskog AB. Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. BMC Neurol. 2021 Dec 8;21(1):476. doi: 10.1186/s12883-021-02498-w.

    PMID: 34879833DERIVED

  • Alme KN, Askim T, Assmus J, Mollnes TE, Naik M, Naess H, Saltvedt I, Ueland PM, Ulvik A, Knapskog AB. Investigating novel biomarkers of immune activation and modulation in the context of sedentary behaviour: a multicentre prospective ischemic stroke cohort study. BMC Neurol. 2021 Aug 16;21(1):318. doi: 10.1186/s12883-021-02343-0.

    PMID: 34399717DERIVED

  • Schellhorn T, Zucknick M, Askim T, Munthe-Kaas R, Ihle-Hansen H, Seljeseth YM, Knapskog AB, Naess H, Ellekjaer H, Thingstad P, Wyller TB, Saltvedt I, Beyer MK. Pre-stroke cognitive impairment is associated with vascular imaging pathology: a prospective observational study. BMC Geriatr. 2021 Jun 14;21(1):362. doi: 10.1186/s12877-021-02327-2.

    PMID: 34126944DERIVED

  • Schellhorn T, Aamodt EB, Lydersen S, Aam S, Wyller TB, Saltvedt I, Beyer MK. Clinically accessible neuroimaging predictors of post-stroke neurocognitive disorder: a prospective observational study. BMC Neurol. 2021 Feb 25;21(1):89. doi: 10.1186/s12883-021-02117-8.

    PMID: 33632149DERIVED

  • Einstad MS, Saltvedt I, Lydersen S, Ursin MH, Munthe-Kaas R, Ihle-Hansen H, Knapskog AB, Askim T, Beyer MK, Naess H, Seljeseth YM, Ellekjaer H, Thingstad P. Associations between post-stroke motor and cognitive function: a cross-sectional study. BMC Geriatr. 2021 Feb 5;21(1):103. doi: 10.1186/s12877-021-02055-7.

    PMID: 33546620DERIVED

  • Munthe-Kaas R, Aam S, Saltvedt I, Wyller TB, Pendlebury ST, Lydersen S, Ihle-Hansen H. Test Accuracy of the Montreal Cognitive Assessment in Screening for Early Poststroke Neurocognitive Disorder: The Nor-COAST Study. Stroke. 2021 Jan;52(1):317-320. doi: 10.1161/STROKEAHA.120.031030. Epub 2020 Nov 30.

    PMID: 33250039DERIVED

  • Alme KN, Knapskog AB, Naess H, Naik M, Beyer M, Ellekjaer H, English C, Hansen HI, Kummeneje CS, Munthe-Kaas R, Saltvedt I, Seljeseth Y, Tan X, Thingstad P, Askim T. Is long-bout sedentary behaviour associated with long-term glucose levels 3 months after acute ischaemic stroke? A prospective observational cohort study. BMJ Open. 2020 Nov 26;10(11):e037475. doi: 10.1136/bmjopen-2020-037475.

    PMID: 33243789DERIVED

  • Gynnild MN, Aakeroy R, Spigset O, Askim T, Beyer MK, Ihle-Hansen H, Munthe-Kaas R, Knapskog AB, Lydersen S, Naess H, Rosstad TG, Seljeseth YM, Thingstad P, Saltvedt I, Ellekjaer H. Vascular risk factor control and adherence to secondary preventive medication after ischaemic stroke. J Intern Med. 2021 Mar;289(3):355-368. doi: 10.1111/joim.13161. Epub 2020 Aug 19.

    PMID: 32743852DERIVED

Biospecimen

Retention: SAMPLES WITH DNA

blood samples

MeSH Terms

Conditions

DementiaCognitive DysfunctionStroke

Condition Hierarchy (Ancestors)

Brain DiseasesCentral Nervous System DiseasesNervous System DiseasesNeurocognitive DisordersMental DisordersCognition DisordersCerebrovascular DisordersVascular DiseasesCardiovascular Diseases

Study Officials

  • Lars Jacob Stovner, md prof

    Norwegian University of Science and Technology

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

December 10, 2015

First Posted

January 8, 2016

Study Start

May 1, 2015

Primary Completion

October 8, 2018

Study Completion

October 8, 2018

Last Updated

February 23, 2022

Record last verified: 2022-02

Locations

NO(1)