Clinical Profile of Patients With Pulmonary Hypertension Due to Lung Diseases ( Single Center Experience)

NCT02774928 | Unknown

• 1 other identifier: Cairo2001
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

Development of pulmonary hypertension (PH) in chronic lung diseases has both functional and prognostic implications . PH in Lung diseases is usually mild to moderate with preserved cardiac output, and evolves slowly alongside the progression of lung disease and hypoxemia . However, a minority of patients develop severe PH with elevations in pulmonary artery pressure that have been described as ''out of proportion'' to the underlying disease . The aim of this study is to compare the characteristics and outcomes of consecutive patients with PH-due to lung diseases diagnosed at our specialist referral center over a 1-year period.

Conditions

Pulmonary Hypertension

Keywords

Pulmonary Hypertension; COPD; ILD; OSA

Outcome Measures

Primary Outcomes (1)

• prevalence of PH

  1 year

Study Arms (3)

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality throughout the world.COPD, a common preventable and treatable disease, is characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases. Exacerbations and comorbidities contribute to the overall severity in individual patients.Spirometry is required to make a clinical diagnosis of COPD; the presence of a post-bronchodilator FEV1/FVC \< 0.70 confirms the presence of persistent airflow limitation and thus of COPD .

Interstitial lung diseases

Interstitial lung disease is a general category that includes many different lung conditions. All interstitial lung diseases affect the interstitium, a part of the lungs' anatomic structure.

Obstructive sleep apnea (OSA)

Obstructive sleep apnea (OSA) is a sleep disorder that involves cessation or significant decrease in airflow in the presence of breathing effort. It is the most common type of sleep-disordered breathing and is characterized by recurrent episodes of upper airway collapse during sleep. These episodes are associated with recurrent oxyhemoglobin desaturations and arousals from sleep. OSA that is associated with excessive daytime sleepiness is commonly called obstructive sleep apnea syndrome-also referred to as obstructive sleep apnea-hypopnea syndrome.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients with chronic lung diseases COPD ILD OSA sarcodosis

You may qualify if:

• COPD diagnosed according to Gold 2015
• Interstial lung diseases
• Obstructive Sleep Apnea
• sarcoidosis

You may not qualify if:

• Bronchogenic carcinoma

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Kasr Alaini

Cairo, 12411, Egypt

RECRUITING

MeSH Terms

Conditions

Hypertension, Pulmonary; Pulmonary Disease, Chronic Obstructive

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Lung Diseases, Obstructive; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Mostafa I Elshazly, MD

  Kasr Alaini school of Medicine

  PRINCIPAL INVESTIGATOR

• Yusif Amin, MD

  Kasr Alaini school of Medicine

  STUDY DIRECTOR

Central Study Contacts

Mostafa I Elshazly, MD

CONTACT

00201001272020; elshazly66@hotmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of pulmonary Medicine

Study Record Dates

• First Submitted: May 13, 2016
• First Posted: May 17, 2016
• Study Start: June 1, 2016
• Primary Completion: May 1, 2017
• Study Completion: May 1, 2017
• Last Updated: July 12, 2016

Record last verified: 2016-07

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)