NCT02637063

Brief Summary

This project will develop and evaluate an interactive blood pressure self-management program for adults with prehypertension. The program will target blood pressure self-monitoring and the five proven lifestyle modifications recommended by JNC-7: weight reduction, the Dietary Approaches to Stop Hypertension (DASH) diet, sodium reduction, physical activity, and alcohol consumption. The multi-modal program uses a combination of brief motivational health coaching, periodic engagement emails, and a robust interactive website to motivate people to take charge of their blood pressure management before they require medication. All program components were designed to conform to the underlying principles of motivational interviewing. Key program components include the use of email and Web-based social networking, personal stories, and a brief motivational coaching session to engage participants and encourage intrinsically motivated behavior changes. Self-assessment and tracking tools are combined with educational content to help participants align their daily lifestyle choices with their personal goals. The Phase I prototype program promoted moderate physical activity and eating fruits and vegetables as part of the DASH diet. Results from the within-group (n = 39) evaluation showed moderate-to-large effect sizes for pre-to-post change in motivation, preparation behavior, self-efficacy, attitudes, and knowledge, and a small significant increase in physical activity. Participants gave the online program high ratings on satisfaction and usability, and reported improvements in confidence, readiness, clarity, change strategies, and interest in visiting the Website as a result of the coaching session. The fully developed Phase II product will be evaluated in a large randomized trial (N = 450) with a 3-month intensive intervention, a 3-month maintenance intervention, and a 3-month follow-up period. The Phase II trial is expected to show reductions in blood pressure and improvements in JNC-recommended health behaviors. These changes in the outcome measures are expected to be mediated by changes in knowledge, attitudes, self-efficacy, behavioral intention, motivation, and patient activation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
203

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Nov 2013

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 1, 2013

Completed
1.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 1, 2015

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

March 1, 2015

Completed
8 months until next milestone

First Submitted

Initial submission to the registry

November 9, 2015

Completed
1 month until next milestone

First Posted

Study publicly available on registry

December 22, 2015

Completed
1.2 years until next milestone

Results Posted

Study results publicly available

March 15, 2017

Completed
Last Updated

March 15, 2017

Status Verified

January 1, 2017

Enrollment Period

1.3 years

First QC Date

November 9, 2015

Results QC Date

October 12, 2016

Last Update Submit

January 24, 2017

Conditions

Keywords

Lifestyle behavior change

Outcome Measures

Primary Outcomes (5)

  • Systolic Blood Pressure

    Blood pressure measurements were taken by participants using a validated, WIFI-enabled blood pressure cuff manufactured by BlipCare and provided to study subjects prior to the baseline assessment. Measurements were automatically uploaded over a WIFI connection to the BlipHub app and study outcomes database. Participants followed a standardized measurement protocol based on the American Heart Association protocol for home blood pressure measurement, involving three consecutive measurements, taken one minute apart after a five-minute seated resting period. Measurements were not observed.

    Baseline, 12 weeks, 24 weeks

  • Diastolic Blood Pressure

    Blood pressure measurements were taken by participants using a validated, WIFI-enabled blood pressure cuff manufactured by BlipCare and provided to study subjects prior to the baseline assessment. Measurements were automatically uploaded over a WIFI connection to the BlipHub app and study outcomes database. Participants followed a standardized measurement protocol based on the American Heart Association protocol for home blood pressure measurement, involving three consecutive measurements, taken one minute apart after a five-minute seated resting period. Measurements were not observed.

    Baseline, 12 weeks, 24 weeks

  • Body Weight

    Body weight measurements were taken by participants using a validated, WIFI-enabled weight scale manufactured by BlipCare and provided to study subjects prior to the baseline assessment. Measurements were automatically uploaded over a WIFI connection to the BlipHub app and study outcomes database. Participants were instructed to take weight measurements at the same time of day each time, preferably first thing in the morning after using the bathroom and before eating or drinking. The weight measurement taken on the date and time closest to the completion date and time of each individual's online survey for that assessment point was analyzed. If no measurements were available within two weeks on either side of that date, weight measurements were considered missing for that assessment period.

    Baseline, 12 weeks, 24 weeks

  • Heart-healthy Dietary Intake (Number of Fruit/Vegetable Servings, White Meat Servings, Low-fat Dairy Servings)

    Participants were asked about their diet during the past month, using DASH-diet related items adapted from several validated food frequency questionnaires. Participants reported on servings consumed (e.g., never, 1-3 times last month, up to 5 or more times a day) of the following foods: fruits, vegetables, dairy, fats and meat. Number of servings was computed for heart-healthy foods (fruits, vegetables and lean meats).

    Baseline, 12 weeks, 24 weeks

  • Heart-unhealthy Dietary Intake (Self-reported Number of Fat Servings, Red Meat Servings, Dairy Fat Servings)

    Participants were asked about their diet during the past month, using DASH-diet related items adapted from several validated food frequency questionnaires. Participants reported on servings consumed (e.g., never, 1-3 times last month, up to 5 or more times a day) of the following foods: fruits, vegetables, dairy, fats and meat. Number of servings was computed for heart-unhealthy foods (red, processed and high-fat prepared meats).

    Baseline, 12 weeks, 24 weeks

Secondary Outcomes (2)

  • Self-reported Lifestyle Change Preparation Behaviors

    Baseline, 12 weeks, 24 weeks

  • Self-reported Self-efficacy for Lifestyle Behaviors

    Baseline, 12 weeks, 24 weeks

Study Arms (3)

BlipHub mobile-web app

EXPERIMENTAL

Mobile web app to promote blood-pressure-reducing diet, physical activity and weight loss.

Behavioral: BlipHub mobile-web app

BlipHub mobile-web app + health coaching

EXPERIMENTAL

Telephonic coach-supported mobile web app to promote blood-pressure-reducing diet, physical activity and weight loss.

Behavioral: BlipHub mobile-web app + health coaching

Usual care

OTHER

No intervention beyond the participants' personal medical care.

Other: Usual care

Interventions

Mobile web app to promote blood-pressure-reducing diet, physical activity and weight loss.

BlipHub mobile-web app

Telephonic coach-supported mobile web app to promote blood-pressure-reducing diet, physical activity and weight loss.

BlipHub mobile-web app + health coaching

No intervention beyond participants' own medical care.

Usual care

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Blood pressure in the JNC-7-defined prehypertension range (SBP 120-139 and/or DBP 80-89)
  • Must be at least 18 years old
  • Must be employed at least part time
  • Must have access to the internet through a WIFI connection in a place where subject was willing to take BP and weight measurements
  • Must be the only participant per household in the study

You may not qualify if:

  • Female subjects must not be pregnant or planning to get pregnant over the course of study
  • Must not have experienced a stroke, heart attack, or heart disease diagnosis in the prior six months
  • Must not be taking antihypertensive medications for any reason

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

ORCAS

Eugene, Oregon, 97401, United States

Location

MeSH Terms

Conditions

Body Weight

Condition Hierarchy (Ancestors)

Signs and SymptomsPathological Conditions, Signs and Symptoms

Results Point of Contact

Title
Amelia J Birney (PI), Director of Research
Organization
Oregon Center for Applied Science

Study Officials

  • Amelia J. Birney, MPH, MCHES

    Oregon Center for Applied Science, Inc.

    PRINCIPAL INVESTIGATOR

Publication Agreements

PI is Sponsor Employee
Yes

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 9, 2015

First Posted

December 22, 2015

Study Start

November 1, 2013

Primary Completion

March 1, 2015

Study Completion

March 1, 2015

Last Updated

March 15, 2017

Results First Posted

March 15, 2017

Record last verified: 2017-01

Data Sharing

IPD Sharing
Will not share

Locations