A Comparator Trial on the Relative Efficacy of Two Triglyceride Forms of Fish Oil

NCT02628483 | Completed Phase 2

• 1 other identifier: 1007-008-PRO-040414
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The health benefits of omega-3 fatty acids have been extensively examined in many published studies, and these benefits have been observed in patients with a diversity of conditions and diseases, including cardiovascular disease (e.g. atrial fibrillation, atherosclerosis, thrombosis, inflammation, sudden cardiac death, etc.), age-related cognitive decline, periodontal disease, rheumatoid arthritis, etc. These fatty acids may also be beneficial to healthy individuals, in terms of preventative health benefits. The balance between omega-6 long chain fatty acids and their omega-3 counterparts is important in health maintenance. An omega-6:omega-3 ratio of 1:1 or 2:1 is recommended for optimal health, yet the average ratio in the North American population is estimated to be as much as 10:1 or even 20:1. A 2014 study of the dietary habits of U.S. adults revealed that, in general, North Americans do not meet the recommended omega-3 fatty acid intake from foods alone. Supplementation may need to be considered, in order to help this population meet their daily needs. Both the Academy of Nutrition and Dietetics and the American Heart Association suggest a prudent approach in recommending an increased intake of omega-3 fatty acids. Although both organisations recommend a preference for obtaining omega-3 fatty acids through fish consumption, both also recognise that supplementation may also be required in order to meet target values, particularly in at-risk populations. Several omega-3 fish oil supplements exist on the market each with their own ratios of EPA and DHA and are available in varying forms including ethyl ester and high triglyceride forms. Differences in product formulation have been shown to have varying health effects.

Conditions

Healthy Volunteers

Outcome Measures

Primary Outcomes (2)

• Red blood cell EPA and DHA

  24 weeks

• Phospholipid EPA and DHA

  4 weeks

Secondary Outcomes (2)

• Red blood cell EPA and DHA

  12 and 16 weeks

• Lipid profile

  24 weeks

Other Outcomes (3)

• Safety Anthropometric Measurements

  4, 12, 16 and 24 weeks

• Safety blood parameters

  24 weeks

• Adverse Events

  24 weeks

Study Arms (2)

Ultimate Omega

EXPERIMENTAL

5 capsules of Ultimate Omega fish oil daily in the morning with food

Dietary Supplement: Fish Oil

Meg-3

ACTIVE COMPARATOR

5 capsules of Meg-3 fish oil daily in the morning with food

Dietary Supplement: Fish Oil

Interventions

Fish Oil DIETARY_SUPPLEMENT

1000mg fish oil per capsule (325mg EPA + 225mg DHA)

Also known as: Ultimate Omega

Ultimate Omega

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female adults aged 18 - 35 (inclusive)
• Healthy as determined from medical history
• Non-smoker, or ex-smoker ≥6 months
• Body mass index 18.5 - 24.9 kg/m2
• Female participants of childbearing potential (i.e. not surgically sterilized or post-menopausal greater than one year) must have negative urine pregnancy test and must be using an effective birth control method
• Willing to avoid alcohol consumption for 24 h prior to every clinic visit
• Willing to maintain a stable body weight, activity level and dietary pattern except for use of the study products, as directed
• Willing and able to provide informed written consent

You may not qualify if:

• Individuals taking prescription or non-prescription health products that may affect the study endpoint (e.g. corticosteroids, prescription anti-inflammatory drugs, blood lipid-lowering drugs (e.g. statins, fibrates, bile acid exchanger resin, phytosterols, niacin or its analogues, carnitine, etc.) in the previous 6 months
• Individuals taking any supplements with omega-3 fatty acids, phytosterols, polyglucosamines (Chitosan) or other lipid-binding ingredients in the previous 6 months
• Individuals who consume omega-3 fatty acid rich fish (salmon, mackerel, herring) more than twice per month
• Unstable use (initiation or change in dose) of antihypertensive medications or thyroid hormone replacement medications within 3 months prior to visit 1
• Use of any weight-loss programs or weight-loss medications (prescription or over-the counter) including, but not limited to, lipase inhibitors, within 6 months prior to visit 1 and throughout the study
• Pregnancy or lactation, or participant unwilling to take appropriate contraceptives for the duration of the study
• History of blood clotting disorders or use of coagulation-inhibiting drugs (e.g. warfarin)
• Presence of major diseases such as diabetes, gastrointestinal, endocrine, cardiovascular, renal, or liver disease
• History of neurological disease (e.g. Parkinson's disease, stroke, traumatic brain injury, etc.)
• History of cancer (excluding non-melanoma skin cancer and basal cell carcinoma) in past 5 years
• Uncontrolled hypertension defined as a seated resting systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg
• Abnormal laboratory test results of clinical significance, including, but not limited to, ALT or AST ≥1.5X the upper limit of normal at screening (visit 1)
• Triglycerides ≥400 mg/dL (≥4.52mmol/L) at screening (visit 1)
• Presence or history (past 6 months) of alcohol or drug abuse; alcohol use of \>2 standard alcoholic drinks per day
• Participant has a known allergy or intolerance to fish/fish oil or any of the ingredients in the test products

Sponsors & Collaborators

• Nordic Pharma, USA: lead
• Nutrasource Pharmaceutical and Nutraceutical Services, Inc.: collaborator

Study Sites (1)

Nutrasource

Guelph, Ontario, N1G 0B4, Canada

Location

MeSH Terms

Interventions

Fish Oils

Intervention Hierarchy (Ancestors)

Oils; Lipids

Study Officials

• Anthony Bier, MD

  Nutrasource Pharmaceutical and Nutraceutical Services, Inc.

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 9, 2015
• First Posted: December 11, 2015
• Study Start: February 1, 2016
• Primary Completion: December 1, 2016
• Study Completion: December 1, 2016
• Last Updated: December 14, 2016

Record last verified: 2016-12

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)