Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma

NCT02613299 | Terminated

• 1 other identifier: 15-007644
• Study Type: observational
• Target: 5
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to determine whether radiation therapy decreases tumor size and tumor spread. The investigators will consent subjects that have been diagnosed with mesothelioma and will undergo radiation therapy followed by surgical resection as their standard of care. The investigators will collect data from past and future medical records as well as data regarding their health status for their lifetime by reviewing life status, treatment status and CT scans.

Conditions

Mesothelioma; Solitary Fibrous Tumor of the Pleura

Outcome Measures

Primary Outcomes (1)

• Survival status upon review of patient records annually

  Up to 10 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients receiving treatment at the Mayo Clinic Rochester that have been diagnosed with mesothelioma and will undergo radiation therapy followed by surgical resection as their standard of care.

You may qualify if:

• Subject provides informed consent
• Subject is \>18 years of age
• Subject is deemed competent for making medical decisions
• Subject is scheduled to undergo radiation followed by extrapleural pneumonectomy.
• Subject is a surgical candidate
• A negative pregnancy test is required in women of child-bearing potential, as standard of care.

You may not qualify if:

• Subject is \<18 years old.

Sponsors & Collaborators

• Mayo Clinic: lead

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

Location

Related Links

• Mayo Clinic Clinical Trials

MeSH Terms

Conditions

Mesothelioma; Solitary Fibrous Tumor, Pleural

Condition Hierarchy (Ancestors)

Adenoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Neoplasms, Mesothelial; Solitary Fibrous Tumors; Neoplasms, Fibrous Tissue; Neoplasms, Connective Tissue; Neoplasms, Connective and Soft Tissue; Pleural Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site

Study Officials

• Dennis Wigle, MD, PhD

  Mayo Clinic

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 20, 2015
• First Posted: November 24, 2015
• Study Start: June 14, 2016
• Primary Completion: May 29, 2025
• Study Completion: May 29, 2025
• Last Updated: July 14, 2025

Record last verified: 2025-07

Locations

US (1)