NCT02613299

Terminated

Surgery for Mesothelioma After Radiation Therapy "SMART" for...

Mayo Clinic Source

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Other study identifiers

Sponsor study identifier

15-007644

Study Type

observational

Actual enrollment (reported)

5

Locations

1 country

Sites

1

Timeline

Study Start

June 14, 2016

Actual (reported)

Primary Completion

May 29, 2025

Actual (reported)

Study Completion

May 29, 2025

Actual (reported)

Brief Summary

The purpose of this study is to determine whether radiation therapy decreases tumor size and tumor spread. The investigators will consent subjects that have been diagnosed with mesothelioma and will undergo radiation therapy followed by surgical resection as their standard of care. The investigators will collect data from past and future medical records as well as data regarding their health status for their lifetime by reviewing life status, treatment status and CT scans.

Registry Overview

Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.

Recruitment status: terminated
Actual enrollment (reported): 5 participants
Study completion date: May 29, 2025
Actual (reported)
Listed locations: 1 countries · 1 sites

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.

First Submitted
November 20, 2015
Actual (reported)
First Posted
November 24, 2015
Actual (reported)
Study Start
June 14, 2016
Actual (reported)
Primary Completion
May 29, 2025
Actual (reported)
Study Completion
May 29, 2025
Actual (reported)

Last Updated: July 14, 2025
Status Verified: July 2025
Last Update Submitted: July 9, 2025

Conditions

Mesothelioma Solitary Fibrous Tumor of the Pleura

Outcome Measures

Primary Outcomes (1)

Survival status upon review of patient records annually
Up to 10 years

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

Sampling MethodNon-Probability Sample

Study Population

Patients receiving treatment at the Mayo Clinic Rochester that have been diagnosed with mesothelioma and will undergo radiation therapy followed by surgical resection as their standard of care.

You may qualify if:

Subject provides informed consent

Sponsors & Collaborators

Mayo Clinic
Otherlead

Study Sites (1)

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

MeSH Terms

Conditions

MesotheliomaSolitary Fibrous Tumor, Pleural

Condition Hierarchy (Ancestors)

AdenomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsNeoplasms, MesothelialSolitary Fibrous TumorsNeoplasms, Fibrous TissueNeoplasms, Connective TissueNeoplasms, Connective and Soft TissuePleural NeoplasmsRespiratory Tract NeoplasmsThoracic NeoplasmsNeoplasms by Site

Study Officials

Dennis Wigle, MD, PhD
Mayo Clinic
PRINCIPAL INVESTIGATOR

Enrollment

5 participants (actual enrollment reported by the registry).

Study Design

Study Type: observational
Observational Model: CASE ONLY
Time Perspective: PROSPECTIVE
Sponsor Type: OTHER
Responsible Party: PRINCIPAL INVESTIGATOR
PI Title: Principal Investigator

Study Record Dates

First Submitted

November 20, 2015

First Posted

November 24, 2015

Study Start

June 14, 2016

Actual (reported)

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Phase 1Completed

NCT02592551

MEDI4736 Or MEDI4736 + Tremelimumab In Surgically Resectable Malignant Pleural Mesothelioma

Phase 2Completed

NCT03683680

Prospectively Collected Pleural Biopsies for Validation of Malignant Pleural Mesothelioma Prognostic Biomarkers

Not ApplicableRecruiting

NCT03531840

Olaparib in People With Malignant Mesothelioma

Phase 2Completed

NCT03436732

Mesothelin-Targeted Immunotoxin LMB-100 in Combination With SEL-110 in Subjects With Malignant Pleural or Peritoneal Mesothelioma

Phase 1Terminated

NCT02838745

Study of Cytoreductive Surgery and Hyperthermic Intraoperative Chemotherapy With Pemetrexed and Cisplatin for MPM

Phase 1Terminated

Subject is \>18 years of age

Subject is deemed competent for making medical decisions

Subject is scheduled to undergo radiation followed by extrapleural pneumonectomy.

Subject is a surgical candidate

A negative pregnancy test is required in women of child-bearing potential, as standard of care.

You may not qualify if:

Subject is \<18 years old.

Contact the study team to confirm eligibility.

Primary Completion

May 29, 2025

Actual (reported)

Study Completion

May 29, 2025

Actual (reported)

Last Updated

July 14, 2025

Record last verified: 2025-07

Source record

Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.

Source: ClinicalTrials.gov.

JSON downloads include source attribution and retrieval details alongside the unchanged original record or the separately normalized values.

Registry identifier: NCT02613299
Data provider: ClinicalTrials.gov
Source updated: 2025-07-14
Normalization version: ctgov-legacy-1

Open registry record

Source retrieved: 2026-10-25 22:40:13 UTC

Locations

US(1)

Study Stopped

Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Links

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

Related Links

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Enrollment

Study Design

Study Record Dates

You may not qualify if:

Source record

Locations