NCT02594657

Brief Summary

Nowadays, ECC exercise can be realized using various modalities that target small or large muscle masses in a segmentary or dynamic way. The training program proposed in this study is realised on an handmade ergocycle which allows eccentric contractions. With this type of ergometer, O2 consumption (VO2) is three to five fold lower than during an exercise realised at the same power output with a concentric ergocycle. Due to this later propertie, which origins are not yet fully identified, there is an increasing interest to embed ECC in rehabilitation programs. The investigators hypothesis that a higher pedal rate will induce a lower oxygen consumption, with the same benefits. This study aims to compare oxygen consumption at two pedal rates : 50 and 80 rotation per minute (rpm). The ultimate goal is to assess efficacy and tolerance of eccentric training on ergocycle and to enhance comprehension of the physiological mecanisms involved in the lower O2 consumption observed.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
15

participants targeted

Target at below P25 for not_applicable healthy

Timeline
Completed

Started Aug 2015

Typical duration for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

July 9, 2015

Completed
23 days until next milestone

Study Start

First participant enrolled

August 1, 2015

Completed
3 months until next milestone

First Posted

Study publicly available on registry

November 3, 2015

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 1, 2016

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

October 1, 2016

Completed
Last Updated

July 29, 2016

Status Verified

July 1, 2016

Enrollment Period

1.1 years

First QC Date

July 9, 2015

Last Update Submit

July 28, 2016

Conditions

Keywords

EccentricErgometerPedal rateOxygen consumptionOnly health volunteers

Outcome Measures

Primary Outcomes (1)

  • Oxygen consumption (VO2 ml/min)

    Oxygen consumption (VO2) is continuously assesse during exercises at 50 and 80 rpm.

    at day 1

Secondary Outcomes (4)

  • Cardiac output( l/min)

    at day 1

  • muscular oxygen kinetic (arbitrary unit and %)

    at day 1

  • Muscular activity (mV)

    at day 1 during one and half minute (1min30s)

  • VO2 (ml/min)

    at day 1

Study Arms (2)

pedal rate ON 50 RPM

EXPERIMENTAL
Procedure: pedal rate on 50 RPM

pedal rate on 80 RPM

EXPERIMENTAL
Procedure: pedal rate on 80 RPM

Interventions

All measurements are performed in two pedalling situations. The two frequencies used will be 50 and 80 RPM. For each subject the running order (50 and 80, 80 and 50) is randomly determined

pedal rate ON 50 RPM

All measurements are performed in two pedalling situations. The two frequencies used will be 50 and 80 RPM. For each subject the running order (50 and 80, 80 and 50) is randomly determined

pedal rate on 80 RPM

Eligibility Criteria

Age18 Years - 55 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • \- Males
  • IMC \<30
  • physically active
  • Pmax concentric \> 200W
  • Pmax \> Pmax théo sédentaire

You may not qualify if:

  • cardio pulmonary, osteo articulary or muscular diseases
  • Eccentric based physical activities or sports (weight liftering, alpine skiing)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU Clermont-Ferrand

Clermont-Ferrand, 63003, France

RECRUITING

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

July 9, 2015

First Posted

November 3, 2015

Study Start

August 1, 2015

Primary Completion

September 1, 2016

Study Completion

October 1, 2016

Last Updated

July 29, 2016

Record last verified: 2016-07

Locations