The Neural Bases of Early Visual and Auditory Processing and Emotion Recognition Deficits in Schizophrenia

NCT02588014 | Unknown DMC

• 1 other identifier: 0018-15-SHA
• Study Type: observational
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this project is to examine potential mechanisms that may underlie early visual and auditory perception as well as visual and auditory affect perception deficits in schizophrenia and the possible connection between these processes. Given that affect perception largely involves visual and/or auditory information processing and likely relies on intact basic visual and/or auditory perceptual mechanisms, the investigators will examine affect perception deficits within the framework of the more basic visual and auditory processes. Specifically, the investigators will examine magnetophysiological correlates of vocal and visual affect discrimination, non-affective face discrimination and voice discrimination, and simple visual and auditory stimulus discrimination, using Magnetoencephalography (MEG), to identify neural mechanisms underlying perceptual deficits, as well as their contribution to affect perception deficits in schizophrenia.

Conditions

Schizophrenia; Healthy

Outcome Measures

Primary Outcomes (1)

• Brain responses to early visual and auditory stimuli as measured by the MEG

  Amplitudes and brain sources of early auditory and visual components as measured by the MEG

  Immediate

Secondary Outcomes (2)

• Correlation between brain responses to early visual and auditory processing and brain patterns of affect perception

  Immediate

• Correlation between brain responses to early visual and auditory processing and social functioning and quality of life questionnaire' grades

  Immediate

Study Arms (2)

Schizophrenia

Individuals with schizophrenia

Other: Magnetoencephalography

Control

Neurotypical individuals

Other: Magnetoencephalography

Interventions

Magnetoencephalography OTHER

Magnetoencephalography is a non-invasive technique for investigating human brain activity. It allows the measurement of ongoing brain activity on a millisecond-by-millisecond basis, and it shows where in the brain activity is produced.

Also known as: MEG, 4D-NeuroImage

Control; Schizophrenia

Eligibility Criteria

• Age: 18 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Individuals diagnosed with schizophrenia

You may qualify if:

• Capable and willing to provide informed consent
• Diagnosis of schizophrenia or schizoaffective
• Right handedness
• Corrected visual acuity
• No color blindness
• Normal hearing
• IQ ≥ 70
• Capable and willing to provide informed consent
• Right handedness
• Corrected visual acuity
• No color blindness
• Normal hearing
• IQ ≥ 70

You may not qualify if:

• Left handedness
• Intellectual Disability
• Impaired vision
• Impaired hearing
• Colour blindness
• History of significant head injury or neurological illness
• Current diagnosis of substance dependence
• Metallic implants
• Severe current mental instability that precludes participation in the MEG task
• Psychiatric history
• Intellectual Disability
• Impaired vision
• Impaired hearing
• Colour blindness
• History of significant head injury or neurological illness

Sponsors & Collaborators

• Shalvata Mental Health Center: lead
• Bar-Ilan University, Israel: collaborator

MeSH Terms

Conditions

Schizophrenia

Interventions

Magnetoencephalography

Condition Hierarchy (Ancestors)

Schizophrenia Spectrum and Other Psychotic Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques

Study Officials

• Yuval Bloch, MD

  Shalvata Mental Health Center

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Yuval Bloch, MD

CONTACT

+972 97478644; yuvalbloch10@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: October 26, 2015
• First Posted: October 27, 2015
• Study Start: November 1, 2015
• Primary Completion: October 1, 2018
• Study Completion: December 1, 2019
• Last Updated: October 27, 2015

Record last verified: 2015-10