Non-Helium Magnetoencephalography in Autism Spectrum Disorder

NCT07064967 | Recruiting DMC

• 1 other identifier: 447A01
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn how brain activity in children with autism spectrum disorder (ASD) differs from typical developing children using magnetoencephalography (MEG). The main questions this study aims to answer are: Do children with ASD show different patterns of neural oscillation compared to typically developing children? Can MEG identify specific brain features that help ASD diagnosis? Participants will undergo MEG scan in both resting and tasking state, and their brain activity will be analyzed for characteristic neural oscillations and connectivity patterns. This study may help develop better tools for early ASD diagnosis.

Conditions

Autism Spectrum Disorder (ASD)

Keywords

Autism Spectrum Disorder; Magnetoencephalography

Outcome Measures

Primary Outcomes (1)

• Identification of Neural Oscillation Characteristics in Children with Autism Spectrum Disorder

  The primary outcome will measure group differences in neural oscillation features (e.g., spectral power and spatial distribution) across frequency bands (alpha, beta, gamma) between children with Autism Spectrum Disorder and typically developing children during resting-state and task-based conditions. Quantified using time-frequency analysis of magnetoencephalography data. Statistical analysis will include independent t-tests (or Mann-Whitney U tests for non-normally distributed data) with false discovery rate (FDR) correction, using SPSS version 27.0.

  Baseline assessment (single time point, within 1 week of enrollment).

Study Arms (2)

ASD

Participants in the ASD group consisted of children diagnosed with Autism Spectrum Disorder according to DSM-5 criteria.

Diagnostic Test: Magnetoencephalography

Control

Participants in the Control group consisted of typically developing children.

Diagnostic Test: Magnetoencephalography

Interventions

Magnetoencephalography DIAGNOSTIC_TEST

Participants will undergo magnetoencephalography scan in both resting and tasking state.

ASD; Control

Eligibility Criteria

• Age: 6 Years - 12 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)
• Sampling Method: Non-Probability Sample

Study Population

Pediatric patients of Guangzhou Women and Children's Medical Center

You may qualify if:

• Boys aged 6 to 12 years;
• Diagnosis of Autism Spectrum Disorder meeting DSM-5 criteria;
• Intelligence quotient (IQ) score \> 70 (assessed via Wechsler Intelligence Scale for Children or other validated cognitive test);
• Sufficient compliance to participate in MEG experiments.

You may not qualify if:

• Comorbid neurological disorders, genetic syndromes, or severe developmental disabilities;
• Metallic implants that may interfere with MEG signal acquisition;
• Current use of antipsychotic medications or sedatives.

Sponsors & Collaborators

• Guangzhou Women and Children's Medical Center: lead
• Beijing X-Magtech Technology Limited: collaborator

Study Sites (1)

Guangzhou Women and Children's medical center

Guangzhou, Guangdong, 511399, China

RECRUITING

MeSH Terms

Conditions

Autism Spectrum Disorder

Interventions

Magnetoencephalography

Condition Hierarchy (Ancestors)

Child Development Disorders, Pervasive; Neurodevelopmental Disorders; Mental Disorders

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Neurological; Diagnostic Techniques and Procedures; Diagnosis; Electrodiagnosis; Magnetometry; Investigative Techniques

Central Study Contacts

Ye Song, Medical Doctor

CONTACT

+86-020-81886332; 15625984282@163.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2025
• First Posted: July 15, 2025
• Study Start: November 5, 2024
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: July 15, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)