Primary Culture of Residual Specimens Obtained From Aspiration of Hepatic Tumor to Predict the Prognosis of the Patients

NCT02587793 | Completed

• 1 other identifier: KMUH-IRB-20140182
• Study Type: observational
• Target: 208
• Locations: 1 country
• Sites: 2

Brief Summary

The aim of this project is to investigate whether the proliferative speeds of cultured cells using our method can be integrated into Barcelona Clinic Liver Cancer (BCLC) staging classification for the possibility of personalized treatment and prediction the outcomes in hepatocellular carcinoma (HCC) patients.

Conditions

Hepatocellular Carcinoma

Keywords

Hepatocellular Carcinoma; primary culture; fine-needle aspiration; cancer-associated fibroblast

Outcome Measures

Primary Outcomes (1)

• survival

  Correlation between the proliferative speeds of cultured cells and one year survival of the patients after aspiration of the tumor will be investigated.

  one year

Secondary Outcomes (1)

• cancer progression

  one year

Study Arms (1)

Barcelona Clinic Liver Cancer (BCLC) staging

The tumor stages of the patient are classified as BCLC stage 0, A, B, C, or D.

Other: not interventional study

Interventions

not interventional study OTHER

Barcelona Clinic Liver Cancer (BCLC) staging

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who are proven to have HCC based on fine-needle aspiration of the tumor and also have residual specimens for culture are included.

You may qualify if:

• Patients are proven to have HCC based on fine-needle aspiration of the tumor.
• Patient have residual specimens obtained from fine-needle aspiration of the tumor.
• Patients agree to participate this study after fully explanation.

You may not qualify if:

• Patients are not proven to have HCC based on fine-needle aspiration of the tumor.
• Patient do not have residual specimens obtained from fine-needle aspiration of the tumor.
• Patients do not agree to participate this study after fully explanation.

Sponsors & Collaborators

• Kaohsiung Medical University Chung-Ho Memorial Hospital: lead

Study Sites (2)

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan

Location

Chang Gung Memorial Hospital

Kaohsiung City, Taiwan

Location

Related Publications (2)

• Lin ZY, Chuang WL, Chuang YH, Yu ML, Hsieh MY, Wang LY, Tsai JF. Discordant influence of amphotericin B on epirubicin cytotoxicity in primary hepatic malignant cells collected by a new primary culture technique. J Gastroenterol Hepatol. 2006 Feb;21(2):398-405. doi: 10.1111/j.1440-1746.2005.04026.x.

  PMID: 16509865 RESULT

• Lin ZY, Wu CC, Chuang YH, Chuang WL. Clinical utility of a simple primary culture method in hepatocellular carcinoma patients. J Gastroenterol Hepatol. 2015 Feb;30(2):352-7. doi: 10.1111/jgh.12693.

  PMID: 25087586 RESULT

Biospecimen

Retention: SAMPLES WITH DNA

If the cultured cells can become cell lines, these cell lines will be stored.

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Liver Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Digestive System Diseases; Liver Diseases

Study Officials

• Zu-Yau Lin, MD

  Kaohsiung Medical University Chung-Ho Memorial Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: October 24, 2015
• First Posted: October 27, 2015
• Study Start: October 1, 2014
• Primary Completion: July 31, 2018
• Study Completion: July 31, 2018
• Last Updated: February 27, 2019

Record last verified: 2019-02

Locations

TW (2)