NCT00769535

Brief Summary

Polymorphisms of HSP70 and tumor necrosis factor-alpha promoter in patients with hepatocellular carcinoma, chronic liver disease and healthy controls will be measured by PCR-RFLP or direct sequencing. The clinical relevance of patients will be compared in those with polymorphism and those without.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
600

participants targeted

Target at P75+ for not_applicable hepatocellular-carcinoma

Timeline
Completed

Started Jan 2006

Geographic Reach
1 country

2 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 1, 2006

Completed
2.2 years until next milestone

First Submitted

Initial submission to the registry

February 26, 2008

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2008

Completed
4 months until next milestone

First Posted

Study publicly available on registry

October 9, 2008

Completed
Last Updated

April 30, 2013

Status Verified

April 1, 2013

Enrollment Period

2.4 years

First QC Date

February 26, 2008

Last Update Submit

April 26, 2013

Conditions

Hepatocellular Carcinoma

Keywords

heat shock protein70tumor necrosis factor-alpha promoterpolymorphism

Outcome Measures

Primary Outcomes (1)

  • Clinical relevance

    year

Secondary Outcomes (1)

  • Clinical relevance

    year

Study Arms (1)

HSP70 and TNF polymorphisms

EXPERIMENTAL
Genetic: Polymorphisms of HSP70 and TNF promoter

Interventions

Polymorphisms of HSP70 and TNF promoterGENETIC

To assess the relationship between clinical relevance and polymorphisms of HSP70 and tumor necrosis factor-alpha with PCR\_RFLP

Also known as: polymorphism of HSP70, polymorphism of tumor necrosis factor-alpha promoter
HSP70 and TNF polymorphisms

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • History proven HCC patients

You may not qualify if:

  • No-definite diagnosed patients

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

Kaohsiung Medical University

Kaohsiung City, Kaohsiung, 807, Taiwan

Location

Kaohsiung Medical University

Kaohsiung City, Kaohsiun, 807, Taiwan

Location

MeSH Terms

Conditions

Carcinoma, Hepatocellular

Condition Hierarchy (Ancestors)

AdenocarcinomaCarcinomaNeoplasms, Glandular and EpithelialNeoplasms by Histologic TypeNeoplasmsLiver NeoplasmsDigestive System NeoplasmsNeoplasms by SiteDigestive System DiseasesLiver Diseases

Study Officials

  • Jung-Fa Tsai, M.D., Ph.D.

    Professor of Medicine

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

February 26, 2008

First Posted

October 9, 2008

Study Start

January 1, 2006

Primary Completion

June 1, 2008

Study Completion

June 1, 2008

Last Updated

April 30, 2013

Record last verified: 2013-04

Locations

TW(2)