Exercise Substrate Utilisation and Endurance Performance Following Short-term Manipulation of Dietary Fat Intake
1 other identifier
interventional
16
1 country
1
Brief Summary
The capacity to burn fat as fuel for exercise may have important implications for sporting performance, with dietary fat intake positively influencing this ability. Endurance performance and the ability to burn fat will be measured in women runners following the consumption of 3 diets varying in the amount of fat and carbohydrate.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2015
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2015
CompletedFirst Submitted
Initial submission to the registry
May 13, 2015
CompletedFirst Posted
Study publicly available on registry
October 6, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2016
CompletedMay 13, 2016
May 1, 2016
1.3 years
May 13, 2015
May 11, 2016
Conditions
Outcome Measures
Primary Outcomes (1)
Rates of fat oxidation during exercise
Rates of fat oxidation to be measured via indirect calorimetry during 90 minutes of submaximal exercise
90 minutes of sub-maximal exercise
Secondary Outcomes (4)
5km running performance
Immediately following measurement of Primary Outcome measure
Change in plasma glucose concentration
90 minutes sub-maximal exercise
Change in Free Fatty Acid concentration
90 minutes sub-maximal exercise
Change in plasma glycerol concentration
90 minutes sub-maximal exercise
Study Arms (3)
High Fat
EXPERIMENTALHigh Fat - Carbohydrate (20%), Fat (65%), Protein (15%)
Normal
EXPERIMENTALNormal - Carbohydrate (50%), Fat (35%) and Protein (15%)
Normal + Extra Fat
EXPERIMENTALNormal + Extra Fat - Carbohydrate (50%), Fat (65%), Protein (15%). Carbohydrate and protein intake identical in absolute amounts to NORM (Normal), with an additional 30% extra energy coming from fat.
Interventions
Normal + Extra Fat - Carbohydrate (50%), Fat (65%), Protein (15%). Carbohydrate and protein intake identical in absolute amounts to NORMAL, with an additional 30% extra energy coming from fat.
Eligibility Criteria
You may qualify if:
- BMI \>17.0 \< 25 kg/m2
- Good General Health
- Accustomed to vigorous physical activity
- Run \> 2 times per week
- V̇O2max \>50ml/kg/min
- Weight Stable \> last 6months
- Non Smoker
- Pre-menopausal, and either eumenorrheic and regularly menstruating, or using monophasic hormonal oral contraceptives for \> 3 months.
You may not qualify if:
- Currently taking part in another scientific/clinical study
- Taking any prescription drug / supplement thought to influence metabolism
- Following unusual dietary practices (such as intermittent fasting or low carbohydrate diets)
- Pregnant
- Breast Feeding
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- University of Birminghamlead
- GlaxoSmithKlinecollaborator
Study Sites (1)
University of Birmingham
Birmingham, West Midlands, B15 2TT, United Kingdom
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Gareth A Wallis, PhD
University of Birmingham
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 13, 2015
First Posted
October 6, 2015
Study Start
March 1, 2015
Primary Completion
June 1, 2016
Study Completion
June 1, 2016
Last Updated
May 13, 2016
Record last verified: 2016-05
Data Sharing
- IPD Sharing
- Will not share