NCT02564601

Brief Summary

This project evaluates the effects of piano training and computerized cognitive training on cognitive performance in healthy older adults compared to controls. The project is intended for healthy older adults (60-80 years) with little to no previous musical training (less than three years of prior musical training or cognitive training and not currently engaged in music reading or musical performance, less than 10 hours of previous cognitive training). Investigators anticipate that musical engagement will serve as an enjoyable cognitive intervention for older adults. Investigators believe that piano training will enhance cognitive performance on executive functions essential for maintaining independence in older adulthood. Learning a musical instrument, while challenging, will improve self-efficacy, mood, and qualtiy of life. Participants engaged in piano training will demonstrate reduced cortisol levels and increased immune function responses. Investigators predict that adults enrolled in computerized cognitive training will demonstrate enhanced memory, working memory and self-efficacy post-training.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
93

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jun 2015

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

June 1, 2015

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

September 16, 2015

Completed
15 days until next milestone

First Posted

Study publicly available on registry

October 1, 2015

Completed
1.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 1, 2017

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 1, 2017

Completed
Last Updated

May 1, 2019

Status Verified

April 1, 2019

Enrollment Period

2 years

First QC Date

September 16, 2015

Last Update Submit

April 29, 2019

Conditions

Keywords

interventioncognitionagingpiano trainingcomputer brain training

Outcome Measures

Primary Outcomes (14)

  • N-Back

    Working Memory Measure in the Visual Domain

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Cued Color Word Stroop

    Cognitive Control, Inhibition

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Digit Coding- WAIS IV subtest

    Simple Processing Speed

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Symbol Search- WAIS IV subtest

    Visual Scanning

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Paced Auditory Serial Addition Task (PASAT)

    Complex processing speed

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Rey Auditory Verbal Learning Test

    Verbal Memory

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Delis Kaplan Executive Function Verbal Fluency subtest

    Category Fluency, Letter Fluency, Category Switching

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Trail Making Test

    Planning and Processing Speed

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Finger Tapper Test

    Motor Speed

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Salivary Cortisol

    Stress Levels

    (CHANGE) up to 16 weeks and after study completion 7 months

  • SIgA levels

    Immune Function

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Musical Performance Self-Efficacy

    Musical Self-Efficacy

    (CHANGE) up to 16 weeks and after study completion 7 months

  • General Self-Efficacy

    General Self-Efficacy

    (CHANGE) up to 16 weeks and after study completion 7 months

  • Cognitive Self-Report Questionnaire (25)

    Mood

    (CHANGE) up to 16 weeks and after study completion 7 months

Study Arms (3)

A1 Piano Training

EXPERIMENTAL

16 weekly classes will be provided to the piano training group. Each piano class session will focus upon review of materials (15-20 min), and the remaining portion of the class will focus upon learning new skills and concepts. This course includes finger dexterity exercises, basic piano technique, and basic piano repertoire.

Behavioral: Piano Training

A2 Computer Cognitive Training

EXPERIMENTAL

16 weekly classes will be provided to the computerized cognitive training group. Computerized cognitive training involves process-based computerized practice of adaptive perceptual exercises. Each computer cognitive training class session will focus upon practice of cognitive exercises that vary in difficulty ranging from basic auditory processing speed to application through memory and working memory exercises. Within each exercise, the stimuli (i.e., tones, speech sounds, words, sentences) become less discriminable and speed of presentation increases (making the exercises more difficult) as performance improves.

Behavioral: Computer Cognitive Training

A 3 No Treatment Controls

NO INTERVENTION

No classes will be provided to our control group. This is a no-treatment control group.

Interventions

Piano TrainingBEHAVIORAL

The intervention focuses upon progressively difficult piano performance exercises (repertoire), technique, and finger dexterity exercises.

A1 Piano Training

The intervention focuses upon progressively difficult perceptual exercises using the Brain Fitness program plus working memory exercises.

A2 Computer Cognitive Training

Eligibility Criteria

Age60 Years - 80 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Between the ages of 60-80
  • native English speakers
  • no pre-existing cognitive impairment or neurological impairment
  • not taking medications affecting memory performance (sleep meds, antidepressants, etc.)
  • Telephone Interview for Cognitive Status (score \>30)
  • no moderate to severe depression
  • no difficulty with hand movements
  • less than three years of formal music training
  • no difficulty with the movement of their hands
  • not currently engaged in music reading or musical performance
  • \< 10 hours of previous cognitive training

You may not qualify if:

  • Those not between 60-80
  • those taking medications affecting memory performance
  • Non-Native English Speakers
  • Those with pre-existing cognitive impairment
  • Telephone Interview for Cognitive Status (score \< 30)
  • Those with difficulty in the movement of their hands
  • Those with more than three years of formal music training or currently engaged in music reading or music performance
  • Those with more than ten hours of cognitive training

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of South Florida

Tampa, Florida, 33620, United States

Location

Related Publications (4)

  • Smith GE, Housen P, Yaffe K, Ruff R, Kennison RF, Mahncke HW, Zelinski EM. A cognitive training program based on principles of brain plasticity: results from the Improvement in Memory with Plasticity-based Adaptive Cognitive Training (IMPACT) study. J Am Geriatr Soc. 2009 Apr;57(4):594-603. doi: 10.1111/j.1532-5415.2008.02167.x. Epub 2009 Feb 9.

  • Duff K, Tometich D, Dennett K. The Modified Telephone Interview for Cognitive Status is More Predictive of Memory Abilities Than the Mini-Mental State Examination. J Geriatr Psychiatry Neurol. 2015 Sep;28(3):193-7. doi: 10.1177/0891988715573532. Epub 2015 Feb 26.

  • Bugos JA, Perlstein WM, McCrae CS, Brophy TS, Bedenbaugh PH. Individualized piano instruction enhances executive functioning and working memory in older adults. Aging Ment Health. 2007 Jul;11(4):464-71. doi: 10.1080/13607860601086504.

  • Bugos JA, Wang Y. Piano Training Enhances Executive Functions and Psychosocial Outcomes in Aging: Results of a Randomized Controlled Trial. J Gerontol B Psychol Sci Soc Sci. 2022 Sep 1;77(9):1625-1636. doi: 10.1093/geronb/gbac021.

Study Officials

  • Jennifer Bugos, PhD

    Assistant Professor

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Assistant Professor

Study Record Dates

First Submitted

September 16, 2015

First Posted

October 1, 2015

Study Start

June 1, 2015

Primary Completion

June 1, 2017

Study Completion

June 1, 2017

Last Updated

May 1, 2019

Record last verified: 2019-04

Data Sharing

IPD Sharing
Will not share

No, there is no plan to share individual participant data. We plan on publishing all data collectively.

Locations