Effect of Aerobic Interval Training on Cardiovascular Function in Aging

NCT01883271 | Completed

• 2 other identifiers: IRB201700044551-2012
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Study objectives:

1. 1.To compare cardiovascular function in older compared to young healthy adults.
2. 2.To compare the effect of 8 weeks of aerobic interval training vs. continuous moderate exercise on cardiovascular function in healthy older adults.
3. 3.Compared to young adults, older adults will have lower cardiovascular function.
4. 4.Compared to continuous moderate intensity exercise training, interval training will be more effective in improving cardiovascular function in older adults.

Conditions

Aging

Outcome Measures

Primary Outcomes (1)

• Change in vascular endothelial function

  Brachial flow-mediated dilation using ultrasonography

  At baseline and after 8 weeks of exercise training

Secondary Outcomes (4)

• Change in factors related with endothelial function

  At baseline and after 8 weeks of exercise training

• Change in arterial stiffness

  At baseline and after 8 weeks of exercise training

• Change in cardiac function

  At baseline and after 8 weeks of exercise training

• Change in maximal oxygen consumption

  At baseline and after 8 weeks of exercise training

Study Arms (4)

High intensity aerobic interval training

EXPERIMENTAL

Older adults will complete 8 weeks of high intensity aerobic interval exercise training.

Other: High intensity aerobic interval training

Continuous moderate intensity exercise

EXPERIMENTAL

Older adults will complete 8 weeks of continuous moderate intensity exercise training.

Other: Continuous moderate intensity exercise

Non-exercise control group

NO INTERVENTION

Older adults assigned to the non-exercise control group will maintain their normal lifestyle for 8 weeks.

Young Healthy controls

NO INTERVENTION

Young healthy subjects will be assigned to the healthy control group and will undergo baseline measures only.

Interventions

High intensity aerobic interval training OTHER

Supervised aerobic interval training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.

High intensity aerobic interval training

Continuous moderate intensity exercise OTHER

Supervised exercise training will be performed on bicycles 4 times per week for 8 weeks. Each training session will last 47 minutes and will consist of continuous moderate intensity cycling at 70% of HRmax.

Continuous moderate intensity exercise

Eligibility Criteria

• Age: 18 Years - 79 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Healthy men and women 55 to 79 years of age
• Sedentary or minimally physically active for at least the prior 1 year.
• Women will be premenopausal or postmenopausal (either natural or surgical) defined as a cessation of menses for at least 2 years.
• Premenopausal women will be eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
• Able to give consent.
• Healthy men and women 18 to 35 years of age
• Sedentary or minimally physically active for at least the prior 1 year.
• Women will be premenopausal, eumenorrheic and will be studied during the early follicular phase (days 1 through 6) of the menstrual cycle.
• Able to give consent.

You may not qualify if:

• history of diabetes
• history of any relevant cardiovascular diseases (myocardial infarction, angina pectoris, history of coronary artery bypass surgery or angioplasty, congestive heart failure, or arrhythmia)
• hypertension (≥160 mmHg systolic or ≥100 mmHg diastolic)
• history of renal impairment
• history of gout or hyperuricemia
• history of hepatic disease or infection with hepatitis B, C
• history of seizures, or other relevant on-going or recurrent illness
• recent (within 3 months) or recurrent hospitalizations
• use of tobacco products
• \>5 % weight change in the prior 6 months.
• current intake of medications that may affect study results
• participation in regular aerobic exercise training (\>30 minutes,
• times/wk in the past year).
• premenopausal women taking oral contraceptives and postmenopausal women taking hormone replacement therapy.
• pregnancy (positive urine pregnancy test) or lactation

Sponsors & Collaborators

• University of Florida: lead

Study Sites (1)

University of Florida

Gainesville, Florida, 32611, United States

Location

Study Officials

• Demetra D Christou, Ph.D

  University of Florida

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 13, 2013
• First Posted: June 21, 2013
• Study Start: May 1, 2013
• Primary Completion: February 21, 2019
• Study Completion: February 21, 2019
• Last Updated: February 25, 2019

Record last verified: 2019-02

Locations

US (1)