NCT02536118

Brief Summary

Medtronic is sponsoring the Micra Registry to further confirm safety and effectiveness of the Micra Transcatheter Pacing System (Micra system) when used as intended, in "real-world" clinical practice, following commercial release. The Micra Registry is conducted within Medtronic's Product Surveillance Registry.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
3,100

participants targeted

Target at P75+ for all trials

Timeline
10mo left

Started Jul 2015

Longer than P75 for all trials

Geographic Reach
24 countries

156 active sites

Status
active not recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress93%
Jul 2015Apr 2027

Study Start

First participant enrolled

July 1, 2015

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

August 17, 2015

Completed
14 days until next milestone

First Posted

Study publicly available on registry

August 31, 2015

Completed
11.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2027

Last Updated

February 4, 2026

Status Verified

January 1, 2026

Enrollment Period

11.8 years

First QC Date

August 17, 2015

Last Update Submit

February 2, 2026

Conditions

Outcome Measures

Primary Outcomes (2)

  • Acute complication rate

    To estimate acute complication rate related to the Micra system and/or implant procedure.

    30-days

  • Long-term complication free survival

    To estimate the chronic complication free survival rate of the Micra system.

    9 years

Secondary Outcomes (5)

  • Pacing impedance (ohms) and pacing threshold (volts)

    Up to 9 years

  • Complications stratified by implant type

    Up to 9 years

  • Estimate Micra System revision rate

    Up to 9 years

  • Estimate System Longevity

    Up to 9 years

  • Confirm the rate response operation of the Micra system

    Approximately 2 years

Other Outcomes (1)

  • Micra System complications, pacing impedance (ohms) and pacing threshold (volts), following exposure to MR environment

    Up to 9 years

Study Arms (1)

Patients implanted with Micra System

Patients implanted with a Micra Transcatheter Pacing System are eligible for enrollment into the Micra PA Registry.

Device: Micra Transcatheter Pacing System

Interventions

The Micra system is a miniaturized single chamber pacemaker system that is delivered via catheter through the femoral vein and is implanted directly inside the right ventricle of the heart. The Micra implantable device is a self-contained, hermetically enclosed, miniaturized single chamber pacemaker. The device is fixated via four electrically inactive nitinol tines, located on the distal end of the device.

Also known as: Micra, Micra TPS
Patients implanted with Micra System

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Patients intended to be implanted with a Micra system are eligible for enrollment and all patients must be consented prior to the implant. Only geographies with regulatory approval for the Micra system are eligible to enroll patients (see locations section). All patients enrolled and successfully implanted with a Micra system will be followed for a minimum of 9 years, unless a patient is exited from the registry due to an unavoidable reason. If a Micra system is not successfully implanted, patients will be exited from the registry unless a Micra System and/or implant procedure related event is identified, for which the patient will be followed until the event is resolved or no further actions need to be taken.

You may qualify if:

  • Patient or legally authorized representative provides written authorization and/or consent per institution and geographical requirements
  • Patient is intended to receive or be treated with a Micra Transcatheter Pacing System and must be enrolled prior to the TPS implant procedure

You may not qualify if:

  • Patient who is, or is expected to be inaccessible for follow-up
  • Patient is currently enrolled in or plans to enroll in any concurrent drug and/or device study that may confound results

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (156)

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Birmingham, Alabama, United States

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Los Angeles, California, United States

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Redwood City, California, United States

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New Haven, Connecticut, United States

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Washington D.C., District of Columbia, United States

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Clearwater, Florida, United States

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Jacksonville, Florida, United States

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Safety Harbor, Florida, United States

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Atlanta, Georgia, United States

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Indianapolis, Indiana, 46202, United States

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West Des Moines, Iowa, United States

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Kansas City, Kansas, United States

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Edgewood, Kentucky, United States

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Louisville, Kentucky, United States

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Salisbury, Maryland, United States

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Silver Spring, Maryland, United States

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Takoma Park, Maryland, United States

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Boston, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Lansing, Michigan, United States

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Ypsilanti, Michigan, United States

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Minneapolis, Minnesota, United States

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Rochester, Minnesota, United States

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Saint Cloud, Minnesota, United States

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Columbia, Missouri, United States

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Kansas City, Missouri, United States

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Morristown, New Jersey, United States

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Ridgewood, New Jersey, United States

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Huntington, New York, United States

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New York, New York, United States

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Poughkeepsie, New York, United States

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Durham, North Carolina, United States

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Raleigh, North Carolina, United States

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Akron, Ohio, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Columbus, Ohio, United States

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Toledo, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Portland, Oregon, United States

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Allentown, Pennsylvania, United States

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Lancaster, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Germantown, Tennessee, United States

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Nashville, Tennessee, United States

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Austin, Texas, United States

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Dallas, Texas, United States

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Fort Worth, Texas, United States

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Houston, Texas, United States

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Plano, Texas, United States

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Milwaukee, Wisconsin, United States

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Brussels, Belgium

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Edegem, Belgium

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Leuven, Belgium

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Kingston, Ontario, Canada

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Montreal, Canada

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Prague, Czechia

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Aarhus, Denmark

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Copenhagen, Denmark

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Hillerød, Denmark

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Odense, Denmark

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Annecy, France

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Bayonne, France

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Bordeaux, France

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Brest, France

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Chambray-lès-Tours, France

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Clermont-Ferrand, France

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Grenoble, France

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Lille, France

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Marseille, France

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Montpellier, France

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Nancy, France

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Nantes, France

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Neuilly-sur-Seine, France

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Rennes, France

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Rouen, France

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Saint-Denis, France

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Saint-Etienne, France

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Strasbourg, France

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Toulouse, France

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Villeurbanne, France

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Aachen, Germany

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Berlin, Germany

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Cologne, Germany

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Dresden, Germany

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Düsseldorf, Germany

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Frankfurt, Germany

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Hamburg, Germany

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Hanover, Germany

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Heidelberg, Germany

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Jena, Germany

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Mainz, Germany

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Münster, Germany

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Tübingen, Germany

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Ulm, Germany

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Athens, Greece

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Marousi, Greece

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Budapest, Hungary

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Reykjavik, Iceland

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Ashkelon, Israel

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Jerusalem, Israel

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Ramat Gan, Israel

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Bari, Italy

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Bologna, Italy

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Brescia, Italy

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Cotignola, Italy

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Milan, Italy

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Pisa, Italy

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Roma, Italy

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Mitaka-shi, Tokyo, Japan

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Shinagawa, Tokyo, Japan

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Suita, Japan

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Yokohama, Japan

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Safat, Kuwait

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Amsterdam, Netherlands

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Breda, Netherlands

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Eindhoven, Netherlands

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Enschede, Netherlands

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Groningen, Netherlands

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Leiden, Netherlands

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Maastricht, Netherlands

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Nieuwegein, Netherlands

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Rotterdam, Netherlands

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The Hague, Netherlands

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Christchurch, New Zealand

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Bergen, Norway

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Trondheim, Norway

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Poznan, Poland

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Zabrze, Poland

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Lisbon, Portugal

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Jeddah, Saudi Arabia

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Riyadh, Saudi Arabia

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A Coruña, Spain

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Barcelona, Spain

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Santiago de Compostela, Spain

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Toledo, Spain

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Vitoria-Gasteiz, Spain

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Uppsala, Sweden

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Basel, Switzerland

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Bern, Switzerland

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Fribourg, Switzerland

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Geneva, Switzerland

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Lausanne, Switzerland

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Lugano, Switzerland

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Zurich, Switzerland

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Birmingham, United Kingdom

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Bristol, United Kingdom

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Leeds, United Kingdom

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Leicester, United Kingdom

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Liverpool, United Kingdom

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London, United Kingdom

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Manchester, United Kingdom

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Middlesbrough, United Kingdom

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Nottingham, United Kingdom

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Southampton, United Kingdom

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Related Publications (5)

  • Piccini JP, Cunnane R, Steffel J, El-Chami MF, Reynolds D, Roberts PR, Soejima K, Steinwender C, Garweg C, Chinitz L, Ellis CR, Stromberg K, Fagan DH, Mont L. Development and validation of a risk score for predicting pericardial effusion in patients undergoing leadless pacemaker implantation: experience with the Micra transcatheter pacemaker. Europace. 2022 Jul 21;24(7):1119-1126. doi: 10.1093/europace/euab315.

  • El-Chami MF, Garweg C, Iacopino S, Al-Samadi F, Martinez-Sande JL, Tondo C, Johansen JB, Prat XV, Piccini JP, Cha YM, Grubman E, Bordachar P, Roberts PR, Soejima K, Stromberg K, Fagan DH, Clementy N. Leadless pacemaker implant, anticoagulation status, and outcomes: Results from the Micra Transcatheter Pacing System Post-Approval Registry. Heart Rhythm. 2022 Feb;19(2):228-234. doi: 10.1016/j.hrthm.2021.10.023. Epub 2021 Oct 29.

  • El-Chami MF, Shinn T, Bansal S, Martinez-Sande JL, Clementy N, Augostini R, Ravindran B, Sagi V, Ramanna H, Garweg C, Roberts PR, Soejima K, Stromberg K, Fagan DH, Zuniga N, Piccini JP. Leadless pacemaker implant with concomitant atrioventricular node ablation: Experience with the Micra transcatheter pacemaker. J Cardiovasc Electrophysiol. 2021 Mar;32(3):832-841. doi: 10.1111/jce.14881. Epub 2021 Jan 23.

  • Garg A, Koneru JN, Fagan DH, Stromberg K, Padala SK, El-Chami MF, Roberts PR, Piccini JP, Cheng A, Ellenbogen KA. Morbidity and mortality in patients precluded for transvenous pacemaker implantation: Experience with a leadless pacemaker. Heart Rhythm. 2020 Dec;17(12):2056-2063. doi: 10.1016/j.hrthm.2020.07.035. Epub 2020 Aug 4.

  • El-Chami MF, Al-Samadi F, Clementy N, Garweg C, Martinez-Sande JL, Piccini JP, Iacopino S, Lloyd M, Vinolas Prat X, Jacobsen MD, Ritter P, Johansen JB, Tondo C, Liu F, Fagan DH, Eakley AK, Roberts PR. Updated performance of the Micra transcatheter pacemaker in the real-world setting: A comparison to the investigational study and a transvenous historical control. Heart Rhythm. 2018 Dec;15(12):1800-1807. doi: 10.1016/j.hrthm.2018.08.005. Epub 2018 Aug 10.

MeSH Terms

Conditions

Bradycardia

Condition Hierarchy (Ancestors)

Arrhythmias, CardiacHeart DiseasesCardiovascular DiseasesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Micra Registry Manager

    Medtronic

    STUDY DIRECTOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
9 Years
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

August 17, 2015

First Posted

August 31, 2015

Study Start

July 1, 2015

Primary Completion (Estimated)

April 1, 2027

Study Completion (Estimated)

April 1, 2027

Last Updated

February 4, 2026

Record last verified: 2026-01

Locations